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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 34
1964 58
1965 29
1966 61
1967 48
1968 86
1969 125
1970 146
1971 170
1972 156
1973 129
1974 158
1975 130
1976 141
1977 124
1978 132
1979 167
1980 178
1981 177
1982 210
1983 242
1984 319
1985 305
1986 296
1987 265
1988 407
1989 526
1990 634
1991 761
1992 790
1993 846
1994 792
1995 861
1996 1015
1997 1139
1998 1157
1999 1151
2000 1265
2001 1342
2002 1691
2003 1675
2004 2037
2005 2063
2006 2284
2007 2198
2008 2360
2009 2280
2010 2375
2011 2395
2012 2493
2013 2759
2014 2944
2015 2814
2016 3003
2017 3019
2018 2920
2019 2988
2020 3271
2021 3779
2022 3562
2023 3364
2024 1218

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27,863 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Page 1
Insulin Resistance: From Mechanisms to Therapeutic Strategies.
Lee SH, Park SY, Choi CS. Lee SH, et al. Diabetes Metab J. 2022 Jan;46(1):15-37. doi: 10.4093/dmj.2021.0280. Epub 2021 Dec 30. Diabetes Metab J. 2022. PMID: 34965646 Free PMC article. Review.
Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. ...In addition, we sugg …
Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined …
Mechanisms of Insulin Action and Insulin Resistance.
Petersen MC, Shulman GI. Petersen MC, et al. Physiol Rev. 2018 Oct 1;98(4):2133-2223. doi: 10.1152/physrev.00063.2017. Physiol Rev. 2018. PMID: 30067154 Free PMC article. Review.
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. ...In this review, both the physiology of insulin action and the pathophysiology of insulin resistance are …
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resi …
Insulin resistance: Review of the underlying molecular mechanisms.
Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Yaribeygi H, et al. J Cell Physiol. 2019 Jun;234(6):8152-8161. doi: 10.1002/jcp.27603. Epub 2018 Oct 14. J Cell Physiol. 2019. PMID: 30317615 Review.
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes ins …
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore c …
The cell biology of systemic insulin function.
Tokarz VL, MacDonald PE, Klip A. Tokarz VL, et al. J Cell Biol. 2018 Jul 2;217(7):2273-2289. doi: 10.1083/jcb.201802095. Epub 2018 Apr 5. J Cell Biol. 2018. PMID: 29622564 Free PMC article. Review.
Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the body. ...In this Beyond the Cell review, we focus on these five stages of the journey of insulin through the body and the captivating cell biology that underlies the interaction of …
Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the body. ...In this Beyond the Cell review, we focu …
Recent Advances in Insulin Therapy.
Wilson LM, Castle JR. Wilson LM, et al. Diabetes Technol Ther. 2020 Dec;22(12):929-936. doi: 10.1089/dia.2020.0065. Epub 2020 May 12. Diabetes Technol Ther. 2020. PMID: 32310681 Free PMC article. Review.
Insulin therapy has advanced remarkably over the past few decades. Ultra-rapid-acting and ultra-long-acting insulin analogs are now commercially available. Many additional insulin formulations are in development. ...
Insulin therapy has advanced remarkably over the past few decades. Ultra-rapid-acting and ultra-long-acting insulin analogs ar …
Insulin Signalling: The Inside Story.
Posner BI. Posner BI. Can J Diabetes. 2017 Feb;41(1):108-113. doi: 10.1016/j.jcjd.2016.07.002. Epub 2016 Sep 7. Can J Diabetes. 2017. PMID: 27614806 Free PMC article. Review.
Insulin signalling begins with binding to its cell surface insulin receptor (IR), which is a tyrosine kinase. ...The peroxovanadium compounds (pVs) were discovered to activate the IRK in the absence of insulin and lead to a full insulin response. Thus, …
Insulin signalling begins with binding to its cell surface insulin receptor (IR), which is a tyrosine kinase. ...The peroxovan …
The Evolution of Insulin and How it Informs Therapy and Treatment Choices.
Hirsch IB, Juneja R, Beals JM, Antalis CJ, Wright EE. Hirsch IB, et al. Endocr Rev. 2020 Oct 1;41(5):733-55. doi: 10.1210/endrev/bnaa015. Endocr Rev. 2020. PMID: 32396624 Free PMC article. Review.
Modifications of the insulin formulation and of the insulin molecule itself have made it possible to approximate the natural endogenous insulin response. Insulin and insulin formulations had to be designed to produce either a constant low basal …
Modifications of the insulin formulation and of the insulin molecule itself have made it possible to approximate the natural e …
Insulin and Insulin Resistance in Alzheimer's Disease.
Sędzikowska A, Szablewski L. Sędzikowska A, et al. Int J Mol Sci. 2021 Sep 15;22(18):9987. doi: 10.3390/ijms22189987. Int J Mol Sci. 2021. PMID: 34576151 Free PMC article. Review.
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. ...Insulin and insulin-like growth factor-1 receptors are expressed on all cell types in the central nervous system. ...
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. ...Insulin and insulin-like growth factor- …
Exercise and Insulin Resistance.
Whillier S. Whillier S. Adv Exp Med Biol. 2020;1228:137-150. doi: 10.1007/978-981-15-1792-1_9. Adv Exp Med Biol. 2020. PMID: 32342455 Review.
Glucose uptake into cells is controlled by a number of pathways, some of which are insulin-dependent. During exercise glucose uptake can occur independently of insulin regulation, and hence research into the effects of exercise on insulin resistance must be c …
Glucose uptake into cells is controlled by a number of pathways, some of which are insulin-dependent. During exercise glucose uptake …
Metabolites as regulators of insulin sensitivity and metabolism.
Yang Q, Vijayakumar A, Kahn BB. Yang Q, et al. Nat Rev Mol Cell Biol. 2018 Oct;19(10):654-672. doi: 10.1038/s41580-018-0044-8. Nat Rev Mol Cell Biol. 2018. PMID: 30104701 Free PMC article. Review.
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling but also involves the complex interplay of multiple metabolic pathways. ...A comprehensive understanding of the metabolic adaptations involve …
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling b …
27,863 results
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