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Quoted phrase not found in phrase index: "Iron accumulation in brain"
Page 1
Neurodegeneration with brain iron accumulation.
Hayflick SJ, Kurian MA, Hogarth P. Hayflick SJ, et al. Handb Clin Neurol. 2018;147:293-305. doi: 10.1016/B978-0-444-63233-3.00019-1. Handb Clin Neurol. 2018. PMID: 29325618 Free PMC article. Review.
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of disorders affecting children and adults. These rare disorders are often first suspected when increased basal ganglia iron is observed …
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of dis …
Wilson's disease: update on pathogenesis, biomarkers and treatments.
Shribman S, Poujois A, Bandmann O, Czlonkowska A, Warner TT. Shribman S, et al. J Neurol Neurosurg Psychiatry. 2021 Oct;92(10):1053-1061. doi: 10.1136/jnnp-2021-326123. Epub 2021 Aug 2. J Neurol Neurosurg Psychiatry. 2021. PMID: 34341141 Review.
The genetic and molecular mechanisms associated with ATP7B dysfunction have been well characterised, but despite extensive efforts to identify genotype-phenotype correlations, the reason why only some patients develop neurological or psychiatric features remains unclear. We discu …
The genetic and molecular mechanisms associated with ATP7B dysfunction have been well characterised, but despite extensive efforts to identi …
Cerebral Iron Deposition in Neurodegeneration.
Dusek P, Hofer T, Alexander J, Roos PM, Aaseth JO. Dusek P, et al. Biomolecules. 2022 May 17;12(5):714. doi: 10.3390/biom12050714. Biomolecules. 2022. PMID: 35625641 Free PMC article. Review.
We also provide an update on mechanisms, biomarkers, and effects of brain iron accumulation in these disorders, focusing on recent publications. ...On the microscopic level, brain iron deposits are present mostly in dystrophic microglia variably …
We also provide an update on mechanisms, biomarkers, and effects of brain iron accumulation in these disorders, focusin …
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression.
Yee PP, Wei Y, Kim SY, Lu T, Chih SY, Lawson C, Tang M, Liu Z, Anderson B, Thamburaj K, Young MM, Aregawi DG, Glantz MJ, Zacharia BE, Specht CS, Wang HG, Li W. Yee PP, et al. Nat Commun. 2020 Oct 27;11(1):5424. doi: 10.1038/s41467-020-19193-y. Nat Commun. 2020. PMID: 33110073 Free PMC article.
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure. ...Neutrophil depletion dampens necrosis. Neutrophils is …
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, t …
Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury.
Geng H, Li Z, Li Z, Zhang Y, Gao Z, Sun L, Li X, Cui J, Ni S, Hao J. Geng H, et al. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2220300120. doi: 10.1073/pnas.2220300120. Epub 2023 Nov 10. Proc Natl Acad Sci U S A. 2023. PMID: 37948584 Free PMC article.
However, it is still unclear whether the maintenance of neuronal iron homeostasis enables to revitalize intrinsic neurogenesis. Herein, we report the regulation of cellular iron homeostasis after SCI via the chelation of excess iron ions and modulation of the …
However, it is still unclear whether the maintenance of neuronal iron homeostasis enables to revitalize intrinsic neurogenesis. Herei …
Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses.
Topiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, Zhou H, McCracken C, Roca-Fernández A, Petersen SE, Raman B, Husain M, Gelernter J, Miller KL, Smith SM, Nichols TE. Topiwala A, et al. PLoS Med. 2022 Jul 14;19(7):e1004039. doi: 10.1371/journal.pmed.1004039. eCollection 2022 Jul. PLoS Med. 2022. PMID: 35834561 Free PMC article.
Whether iron accumulation occurs in moderate drinkers is unknown. Our objectives were to investigate evidence in support of causal relationships between alcohol consumption and brain iron levels and to examine whether higher brain iron re …
Whether iron accumulation occurs in moderate drinkers is unknown. Our objectives were to investigate evidence in support of ca …
Brain iron transport.
Qian ZM, Ke Y. Qian ZM, et al. Biol Rev Camb Philos Soc. 2019 Oct;94(5):1672-1684. doi: 10.1111/brv.12521. Epub 2019 Jun 12. Biol Rev Camb Philos Soc. 2019. PMID: 31190441 Review.
Brain iron is a crucial participant and regulator of normal physiological activity. ...Abnormally high brain iron levels have been observed in various neurodegenerative diseases, including neurodegeneration with brain iron accum …
Brain iron is a crucial participant and regulator of normal physiological activity. ...Abnormally high brain iron …
Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model.
Bao WD, Zhou XT, Zhou LT, Wang F, Yin X, Lu Y, Zhu LQ, Liu D. Bao WD, et al. Aging Cell. 2020 Nov;19(11):e13235. doi: 10.1111/acel.13235. Epub 2020 Oct 17. Aging Cell. 2020. PMID: 33068460 Free PMC article.
Incidence of intracerebral hemorrhage (ICH) and brain iron accumulation increases with age. Excess iron accumulation in brain tissues post-ICH induces oxidative stress and neuronal damage. ...Higher serum miR-124 levels were correlated wi …
Incidence of intracerebral hemorrhage (ICH) and brain iron accumulation increases with age. Excess iron accum …
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11.
Li X, Zhang W, Xing Z, Hu S, Zhang G, Wang T, Wang T, Fan Q, Chen G, Cheng J, Jiang X, Cai R. Li X, et al. Cell Death Dis. 2024 Feb 23;15(2):168. doi: 10.1038/s41419-024-06558-0. Cell Death Dis. 2024. PMID: 38395990 Free PMC article.
Glioblastoma (GBM) cells require large amounts of iron for tumor growth and progression, which makes these cells vulnerable to destruction via ferroptosis induction. ...Mechanistically, SIRT3 inhibition led to ferrous iron and ROS accumulation in the mitochon …
Glioblastoma (GBM) cells require large amounts of iron for tumor growth and progression, which makes these cells vulnerable to destru …
Iron and Targeted Iron Therapy in Alzheimer's Disease.
Wang J, Fu J, Zhao Y, Liu Q, Yan X, Su J. Wang J, et al. Int J Mol Sci. 2023 Nov 15;24(22):16353. doi: 10.3390/ijms242216353. Int J Mol Sci. 2023. PMID: 38003544 Free PMC article. Review.
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. beta-amyloid plaque (Abeta) deposition and hyperphosphorylated tau, as well as dysregulated energy metabolism in the brain, are key factors in the progression of AD. Many studies have obser …
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. beta-amyloid plaque (Abeta) deposition and hyperphosphoryla …
536 results