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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1954 2
1955 1
1965 2
1966 1
1967 1
1969 1
1971 6
1973 5
1974 6
1975 7
1976 6
1977 8
1978 6
1979 5
1980 9
1981 4
1982 13
1983 11
1984 11
1985 13
1986 19
1987 29
1988 26
1989 29
1990 23
1991 20
1992 18
1993 19
1994 20
1995 14
1996 24
1997 25
1998 21
1999 17
2000 22
2001 24
2002 23
2003 33
2004 22
2005 25
2006 35
2007 45
2008 47
2009 66
2010 50
2011 46
2012 57
2013 51
2014 51
2015 59
2016 45
2017 50
2018 57
2019 72
2020 67
2021 76
2022 78
2023 72
2024 23

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1,469 results

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Page 1
Diabetic keratopathy.
Yeung A, Dwarakanathan S. Yeung A, et al. Dis Mon. 2021 May;67(5):101135. doi: 10.1016/j.disamonth.2021.101135. Epub 2021 Feb 4. Dis Mon. 2021. PMID: 33551178
Diabetic keratopathy is a significant problem that is commonly overlooked and underdiagnosed by many healthcare providers. More than half of the diabetic population can have tear film changes, corneal epithelial abnormalities, neurotrophic keratopathy, and increased …
Diabetic keratopathy is a significant problem that is commonly overlooked and underdiagnosed by many healthcare providers. More than …
Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study.
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J. Gazzah A, et al. Ann Oncol. 2022 Apr;33(4):416-425. doi: 10.1016/j.annonc.2021.12.012. Epub 2022 Jan 10. Ann Oncol. 2022. PMID: 35026412 Free article. Clinical Trial.
The DLT population comprised 28 patients; DLTs (reversible grade 3 microcystic keratopathy) occurred in three of eight patients treated with tusamitamab ravtansine 120 mg/m(2) and in two of three patients treated with 150 mg/m(2). ...CONCLUSIONS: Tusamitamab ravtansine had …
The DLT population comprised 28 patients; DLTs (reversible grade 3 microcystic keratopathy) occurred in three of eight patients treat …
Infectious crystalline keratopathy.
Porter AJ, Lee GA, Jun AS. Porter AJ, et al. Surv Ophthalmol. 2018 Jul-Aug;63(4):480-499. doi: 10.1016/j.survophthal.2017.10.008. Epub 2017 Oct 31. Surv Ophthalmol. 2018. PMID: 29097211 Review.
Infectious crystalline keratopathy was first reported by Gorovoy and colleagues in 1983 when they identified bacteria colonizing a cornea after a penetrating keratoplasty. ...Local immunosuppression contributes to the quiescent nature and the limited inflammatory response …
Infectious crystalline keratopathy was first reported by Gorovoy and colleagues in 1983 when they identified bacteria colonizing a co …
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy.
Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J. Kinoshita S, et al. N Engl J Med. 2018 Mar 15;378(11):995-1003. doi: 10.1056/NEJMoa1712770. N Engl J Med. 2018. PMID: 29539291 Free article. Clinical Trial.
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured human CECs supp …
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and r …
Neurotrophic keratopathy.
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Geerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C. Dua HS, et al. Prog Retin Eye Res. 2018 Sep;66:107-131. doi: 10.1016/j.preteyeres.2018.04.003. Epub 2018 Apr 23. Prog Retin Eye Res. 2018. PMID: 29698813 Review.
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. ...
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without s …
Neurotrophic keratopathy and refractive surgery.
Kristan J, Kang JJ. Kristan J, et al. Curr Opin Ophthalmol. 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. Curr Opin Ophthalmol. 2021. PMID: 33989233 Review.
In patients without a history of neuropathy, refractive surgery can lead to destruction of corneal nerves and may predispose to keratopathy. The purpose of this review is to provide an update on the effect of refractive surgery on corneal nerve function and the potential f …
In patients without a history of neuropathy, refractive surgery can lead to destruction of corneal nerves and may predispose to keratopat …
Antibody-Drug Conjugates and Ocular Toxicity.
Jaffry M, Choudhry H, Aftab OM, Dastjerdi MH. Jaffry M, et al. J Ocul Pharmacol Ther. 2023 Dec;39(10):675-691. doi: 10.1089/jop.2023.0069. Epub 2023 Aug 23. J Ocul Pharmacol Ther. 2023. PMID: 37615544 Review.
Some of the most common toxicities include microcyst-like epithelial keratopathy and dry eye. We discuss proposed mechanisms of ocular toxicity and describe the reports that mention these toxicities. ...
Some of the most common toxicities include microcyst-like epithelial keratopathy and dry eye. We discuss proposed mechanisms of ocula …
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R. Pflugfelder SC, et al. Ophthalmology. 2020 Jan;127(1):14-26. doi: 10.1016/j.ophtha.2019.08.020. Epub 2019 Aug 26. Ophthalmology. 2020. PMID: 31585826 Free article. Clinical Trial.
PURPOSE: To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy. DESIGN: Multicenter, randomized, double-masked, vehicle-controlled trial. PARTICIPANTS: Patients with neurotr …
PURPOSE: To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic …
Infectious crystalline keratopathy.
Sharma N, Vajpayee RB, Pushker N, Vajpayee M. Sharma N, et al. CLAO J. 2000 Jan;26(1):40-3. CLAO J. 2000. PMID: 10656309 Review.
PURPOSE: To review the diagnosis, microbial and pathological features, pathogenesis, and treatment of infectious crystalline keratopathy (ICK). METHODS: We reviewed the literature on infectious crystalline keratopathy. ...
PURPOSE: To review the diagnosis, microbial and pathological features, pathogenesis, and treatment of infectious crystalline keratopathy …
Cenegermin for the treatment of dry eye disease.
Coco G, Piccotti G, Romano V, Ferro Desideri L, Vagge A, Traverso CE, Pellegrini M, Bruscolini A, Marenco M, Giannaccare G. Coco G, et al. Drugs Today (Barc). 2023 Mar;59(3):113-123. doi: 10.1358/dot.2023.59.3.3521858. Drugs Today (Barc). 2023. PMID: 36847622 Review.
Since NGF has shown in both in vitro and in vivo studies to promote corneal healing, to enhance conjunctival epithelium differentiation and mucin secretion, and to stimulate tear film production and functionality, it could provide potential benefits also in patients with DED. A r …
Since NGF has shown in both in vitro and in vivo studies to promote corneal healing, to enhance conjunctival epithelium differentiation and …
1,469 results