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Page 1
Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives.
Qiu H, Novikov A, Vallon V. Qiu H, et al. Diabetes Metab Res Rev. 2017 Jul;33(5). doi: 10.1002/dmrr.2886. Epub 2017 Feb 23. Diabetes Metab Res Rev. 2017. PMID: 28099783 Review.
However, a potential side effect that has been reported with SGLT2 inhibitors in patients with T2DM and particularly during off-label use in patients with type 1 diabetes is diabetic ketoacidosis. The US Food and Drug Administration recently warned that SGLT2 inhibitors ma …
However, a potential side effect that has been reported with SGLT2 inhibitors in patients with T2DM and particularly during off-label use in …
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.
Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Myers SR, Nigrovic LE, Garro A, Brown KM, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, DePiero AD, Kwok MY, Perry CS 3rd, Olsen CS, Casper TC, Dean JM, Glaser NS; PECARN DKA FLUID Study Group. Kuppermann N, et al. N Engl J Med. 2018 Jun 14;378(24):2275-2287. doi: 10.1056/NEJMoa1716816. N Engl J Med. 2018. PMID: 29897851 Free PMC article. Clinical Trial.
The primary outcome was a decline in mental status (two consecutive Glasgow Coma Scale scores of <14, on a scale ranging from 3 to 15, with lower scores indicating worse mental status) during treatment for diabetic ketoacidosis. ...Memory and IQ scores …
The primary outcome was a decline in mental status (two consecutive Glasgow Coma Scale scores of <14, on a scale ranging from 3 to …
The SQuID protocol (subcutaneous insulin in diabetic ketoacidosis): Impacts on ED operational metrics.
Griffey RT, Schneider RM, Girardi M, Yeary J, McCammon C, Frawley L, Ancona R, Cruz-Bravo P. Griffey RT, et al. Acad Emerg Med. 2023 Aug;30(8):800-808. doi: 10.1111/acem.14685. Epub 2023 Feb 27. Acad Emerg Med. 2023. PMID: 36775281
BACKGROUND: Studies using fast-acting subcutaneous (SQ) insulin analogs in diabetic ketoacidosis (DKA) have demonstrated efficacy, safety, and cost-effectiveness, allowing treatment of mild-to-moderate (MTM)-severity DKA patients in non-intensive care unit (ICU) settings. …
BACKGROUND: Studies using fast-acting subcutaneous (SQ) insulin analogs in diabetic ketoacidosis (DKA) have demonstrated efficacy, sa …
Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study.
Pasquel FJ, Tsegka K, Wang H, Cardona S, Galindo RJ, Fayfman M, Davis G, Vellanki P, Migdal A, Gujral U, Narayan KMV, Umpierrez GE. Pasquel FJ, et al. Diabetes Care. 2020 Feb;43(2):349-357. doi: 10.2337/dc19-1168. Epub 2019 Nov 8. Diabetes Care. 2020. PMID: 31704689 Free PMC article.
OBJECTIVE: Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. ...After adjustment for age, sex, B …
OBJECTIVE: Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyp …
Machine learning prediction models and nomogram to predict the risk of in-hospital death for severe DKA: A clinical study based on MIMIC-IV, eICU databases, and a college hospital ICU.
Xie W, Li Y, Meng X, Zhao M. Xie W, et al. Int J Med Inform. 2023 Jun;174:105049. doi: 10.1016/j.ijmedinf.2023.105049. Epub 2023 Mar 27. Int J Med Inform. 2023. PMID: 37001474 Free article.
AIM: To establish a prediction model and assess the risk factors for severe diabetic ketoacidosis (DKA) in adult patients during the ICU. ...Net Reclassification Improvement (NRI) was used to compare the predictive power of the two models. RESULTS: A multivar …
AIM: To establish a prediction model and assess the risk factors for severe diabetic ketoacidosis (DKA) in adult patients duri …
Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis.
Trainor JL, Glaser NS, Tzimenatos L, Stoner MJ, Brown KM, McManemy JK, Schunk JE, Quayle KS, Nigrovic LE, Rewers A, Myers SR, Bennett JE, Kwok MY, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) FLUID Study Group. Trainor JL, et al. Ann Emerg Med. 2023 Aug;82(2):167-178. doi: 10.1016/j.annemergmed.2023.01.001. Epub 2023 Apr 5. Ann Emerg Med. 2023. PMID: 37024382 Clinical Trial.
Mild (0 to <5%), moderate (5 to <10%), and severe (10%) dehydration were observed in 47% (N=379), 42% (N=343), and 11% (N=89) of episodes, respectively. ...Although biochemical measures were more closely associated with the severity of dehydration than clinical asses …
Mild (0 to <5%), moderate (5 to <10%), and severe (10%) dehydration were observed in 47% (N=379), 42% (N=343), and 11% (N=89) o …
Diabetic ketoacidosis.
Bruyette DS. Bruyette DS. Semin Vet Med Surg Small Anim. 1997 Nov;12(4):239-47. doi: 10.1016/s1096-2867(97)80016-3. Semin Vet Med Surg Small Anim. 1997. PMID: 10889872 Review.
Diabetic ketoacidosis (DKA) is a complex and potentially fatal metabolic disorder in patients with diabetes mellitus. ...A combination of insulin deficiency, increased stress hormone levels, and volume depletion account for the laboratory abnormalities and clinical signs …
Diabetic ketoacidosis (DKA) is a complex and potentially fatal metabolic disorder in patients with diabetes mellitus. ...A combinatio …
Dose-dependent relationship between SGLT2 inhibitor hold time and risk for postoperative anion gap acidosis: a single-centre retrospective analysis.
Steinhorn B, Wiener-Kronish J. Steinhorn B, et al. Br J Anaesth. 2023 Oct;131(4):682-686. doi: 10.1016/j.bja.2023.06.063. Epub 2023 Aug 2. Br J Anaesth. 2023. PMID: 37541949
This medication class predisposes patients to euglycaemic diabetic ketoacidosis, particularly during times of physiologic stress, including fasting and surgery. ...A significant interaction between hold time and emergency surgery was observed, whereas there was no a …
This medication class predisposes patients to euglycaemic diabetic ketoacidosis, particularly during times of physiologic stress, inc …
Remission in Ketosis-Prone Diabetes.
Kikani N, Balasubramanyam A. Kikani N, et al. Endocrinol Metab Clin North Am. 2023 Mar;52(1):165-174. doi: 10.1016/j.ecl.2022.06.005. Epub 2022 Nov 4. Endocrinol Metab Clin North Am. 2023. PMID: 36754492 Review.
Heterogeneous forms of Ketosis-prone diabetes (KPD) are characterized by patients who present with diabetic ketoacidosis (DKA) but lack the typical features and biomarkers of autoimmune T1D. The A-beta+ subgroup of KPD provides unique insight into the concept of "remission …
Heterogeneous forms of Ketosis-prone diabetes (KPD) are characterized by patients who present with diabetic ketoacidosis (DKA) but la …
Hyperlactatemia in diabetic ketoacidosis.
Masharani U, Strycker LA, Lazar AA, Wu K, Brooks GA. Masharani U, et al. Diabet Med. 2022 Apr;39(4):e14723. doi: 10.1111/dme.14723. Epub 2021 Oct 22. Diabet Med. 2022. PMID: 34655270
AIMS: The study examined the prevalence and degree of lactate elevation in diabetic ketoacidosis, and explored which biochemical abnormalities predicted L-lactate levels. METHODS: We reviewed episodes of diabetic ketoacidosis from 79 diabetes patients (one ep …
AIMS: The study examined the prevalence and degree of lactate elevation in diabetic ketoacidosis, and explored which biochemical abno …
1,659 results