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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 1
1954 2
1955 1
1958 1
1965 1
1966 1
1968 1
1969 1
1970 3
1971 8
1972 4
1973 2
1974 6
1975 9
1976 7
1977 12
1978 17
1979 10
1980 7
1981 13
1982 11
1983 21
1984 11
1985 9
1986 8
1987 10
1988 8
1989 6
1990 10
1991 8
1992 6
1993 2
1994 5
1995 8
1996 4
1997 11
1998 8
1999 22
2000 14
2001 15
2002 24
2003 20
2004 25
2005 22
2006 27
2007 31
2008 25
2009 20
2010 20
2011 22
2012 28
2013 34
2014 35
2015 32
2016 39
2017 61
2018 58
2019 76
2020 86
2021 89
2022 93
2023 87
2024 28

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1,166 results

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Page 1
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.
Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium. Nuffield Department of Population Health Renal Studies Group, et al. Lancet. 2022 Nov 19;400(10365):1788-1801. doi: 10.1016/S0140-6736(22)02074-8. Epub 2022 Nov 6. Lancet. 2022. PMID: 36351458 Free PMC article.
Summary-level data used for analysis were extracted from published reports or provided by trial investigators, and inverse-variance-weighted meta-analyses were conducted to estimate treatment effects. ...For all outcomes, results were broadly similar irrespective of tri …
Summary-level data used for analysis were extracted from published reports or provided by trial investigators, and inverse-variance-w …
Ketones and the Heart: Metabolic Principles and Therapeutic Implications.
Matsuura TR, Puchalska P, Crawford PA, Kelly DP. Matsuura TR, et al. Circ Res. 2023 Mar 31;132(7):882-898. doi: 10.1161/CIRCRESAHA.123.321872. Epub 2023 Mar 30. Circ Res. 2023. PMID: 36996176 Free PMC article. Review.
Enhanced cardiac ketone utilization during HF is mediated by increased availability due to systemic ketosis and a cardiac autonomous upregulation of ketolytic enzymes. ...Additional pleotropic signaling properties of beta-hydroxybutyrate and AcAc are discussed including ep …
Enhanced cardiac ketone utilization during HF is mediated by increased availability due to systemic ketosis and a cardiac autonomous …
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Cox PJ, Kirk T, Ashmore T, Willerton K, Evans R, Smith A, Murray AJ, Stubbs B, West J, McLure SW, King MT, Dodd MS, Holloway C, Neubauer S, Drawer S, Veech RL, Griffin JL, Clarke K. Cox PJ, et al. Cell Metab. 2016 Aug 9;24(2):256-68. doi: 10.1016/j.cmet.2016.07.010. Epub 2016 Jul 27. Cell Metab. 2016. PMID: 27475046 Free article. Clinical Trial.
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood outside of starvation or diabetic crisis. ...
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlook …
The Ketogenic Diet and Alzheimer's Disease.
Hersant H, Grossberg G. Hersant H, et al. J Nutr Health Aging. 2022;26(6):606-614. doi: 10.1007/s12603-022-1807-7. J Nutr Health Aging. 2022. PMID: 35718870 Free article. Review.
The purpose of this review is to compare the methods of inducing hyperketonemia and their impact on AD prevention/treatment, as well as to explore the possible benefits of a combined approach. METHODS: The PubMed database was searched for clinical trials and randomized …
The purpose of this review is to compare the methods of inducing hyperketonemia and their impact on AD prevention/treatment, as well as to e …
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection.
Hou YC, Zheng CM, Yen TH, Lu KC. Hou YC, et al. Int J Mol Sci. 2020 Oct 22;21(21):7833. doi: 10.3390/ijms21217833. Int J Mol Sci. 2020. PMID: 33105763 Free PMC article. Review.
The application of SGLT2i also provided metabolic and hemodynamic benefits in molecular aspects. The recent DAPA-CKD trial and EMPEROR-Reduced trial provided clinical evidence of renal and cardiac protection, even in non-DM patients. ...
The application of SGLT2i also provided metabolic and hemodynamic benefits in molecular aspects. The recent DAPA-CKD trial and EMPERO …
Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives.
Qiu H, Novikov A, Vallon V. Qiu H, et al. Diabetes Metab Res Rev. 2017 Jul;33(5). doi: 10.1002/dmrr.2886. Epub 2017 Feb 23. Diabetes Metab Res Rev. 2017. PMID: 28099783 Review.
Here, we review the basic metabolism of ketone bodies, the triggers of diabetic ketoacidosis, and potential mechanisms by which SGLT2 inhibitors may facilitate the development of ketosis or ketoacidosis. This provides the rationale for measures to lower the risk. ...
Here, we review the basic metabolism of ketone bodies, the triggers of diabetic ketoacidosis, and potential mechanisms by which SGLT2 inhibi …
Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease.
Phillips MCL, Deprez LM, Mortimer GMN, Murtagh DKJ, McCoy S, Mylchreest R, Gilbertson LJ, Clark KM, Simpson PV, McManus EJ, Oh JE, Yadavaraj S, King VM, Pillai A, Romero-Ferrando B, Brinkhuis M, Copeland BM, Samad S, Liao S, Schepel JAC. Phillips MCL, et al. Alzheimers Res Ther. 2021 Feb 23;13(1):51. doi: 10.1186/s13195-021-00783-x. Alzheimers Res Ther. 2021. PMID: 33622392 Free PMC article. Clinical Trial.
Changes in cardiovascular risk factors were mostly favourable, and adverse effects were mild. CONCLUSIONS: This is the first randomized trial to investigate the impact of a ketogenic diet in patients with uniform diagnoses of AD. ...The trial was registered o …
Changes in cardiovascular risk factors were mostly favourable, and adverse effects were mild. CONCLUSIONS: This is the first randomized …
Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation.
Evans M, Cogan KE, Egan B. Evans M, et al. J Physiol. 2017 May 1;595(9):2857-2871. doi: 10.1113/JP273185. Epub 2016 Dec 7. J Physiol. 2017. PMID: 27861911 Free PMC article. Review.
Recent development of ketone esters facilitates acute ingestion of betaHB that results in nutritional ketosis without necessitating restrictive dietary practices. Initial reports suggest this strategy alters the metabolic response to exercise and improves exercise performa …
Recent development of ketone esters facilitates acute ingestion of betaHB that results in nutritional ketosis without necessitating r …
Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.
Laffel LM, Kanapka LG, Beck RW, Bergamo K, Clements MA, Criego A, DeSalvo DJ, Goland R, Hood K, Liljenquist D, Messer LH, Monzavi R, Mouse TJ, Prahalad P, Sherr J, Simmons JH, Wadwa RP, Weinstock RS, Willi SM, Miller KM; CGM Intervention in Teens and Young Adults with T1D (CITY) Study Group; CDE10. Laffel LM, et al. JAMA. 2020 Jun 16;323(23):2388-2396. doi: 10.1001/jama.2020.6940. JAMA. 2020. PMID: 32543683 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the effect of CGM on glycemic control in adolescents and young adults with type 1 diabetes. DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial conducted between January 2018 and May 2019 at 14 endocrinology practices in the U …
OBJECTIVE: To determine the effect of CGM on glycemic control in adolescents and young adults with type 1 diabetes. DESIGN, SETTING, AND PAR …
Euglycemic Ketoacidosis as a Complication of SGLT2 Inhibitor Therapy.
Palmer BF, Clegg DJ. Palmer BF, et al. Clin J Am Soc Nephrol. 2021 Aug;16(8):1284-1291. doi: 10.2215/CJN.17621120. Epub 2021 Feb 9. Clin J Am Soc Nephrol. 2021. PMID: 33563658 Free PMC article. Review.
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are drugs designed to lower plasma glucose concentration by inhibiting Na(+)-glucose-coupled transport in the proximal tubule. Clinical trials demonstrate these drugs have favorable effects on cardiovascular outcomes to inc …
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are drugs designed to lower plasma glucose concentration by inhibiting Na(+)-glucose-coupl …
1,166 results