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Page 1
Role of LCAT in Atherosclerosis.
Ossoli A, Simonelli S, Vitali C, Franceschini G, Calabresi L. Ossoli A, et al. J Atheroscler Thromb. 2016;23(2):119-27. doi: 10.5551/jat.32854. Epub 2015 Nov 26. J Atheroscler Thromb. 2016. PMID: 26607351 Free article. Review.
Studies in humans, in particular in the general population, in subjects at high cardiovascular risk, and in carriers of genetic LCAT deficiency in an excellent model to evaluate the correlation between the reduction of LCAT activity and atherosclerosis also gave con …
Studies in humans, in particular in the general population, in subjects at high cardiovascular risk, and in carriers of genetic LCAT …
Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020.
Pavanello C, Calabresi L. Pavanello C, et al. Curr Opin Lipidol. 2020 Aug;31(4):232-237. doi: 10.1097/MOL.0000000000000697. Curr Opin Lipidol. 2020. PMID: 32618730 Review.
PURPOSE OF REVIEW: Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. ...SUMMARY: Familial LCAT deficiency is a rare disease, with serious clinical manifestations, which can occur in the first decad …
PURPOSE OF REVIEW: Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. .. …
Current Status of Familial LCAT Deficiency in Japan.
Kuroda M, Bujo H, Yokote K, Murano T, Yamaguchi T, Ogura M, Ikewaki K, Koseki M, Takeuchi Y, Nakatsuka A, Hori M, Matsuki K, Miida T, Yokoyama S, Wada J, Harada-Shiba M. Kuroda M, et al. J Atheroscler Thromb. 2021 Jul 1;28(7):679-691. doi: 10.5551/jat.RV17051. Epub 2021 Apr 18. J Atheroscler Thromb. 2021. PMID: 33867422 Free PMC article. Review.
Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial …
Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second pos …
Lipoprotein-X fifty years after its original discovery.
Fellin R, Manzato E. Fellin R, et al. Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):4-8. doi: 10.1016/j.numecd.2018.09.006. Epub 2018 Sep 26. Nutr Metab Cardiovasc Dis. 2019. PMID: 30503707 Review.
However, the concentration of Lp-X in plasma is determined also by the degree of the cholestasis, the residual liver function, and the LCAT deficiency. The Lp-X catabolism seems to be mediated by the reticuloendothelial system and possibly the kidney. ...
However, the concentration of Lp-X in plasma is determined also by the degree of the cholestasis, the residual liver function, and the LC …
LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.
Mehta R, Elías-López D, Martagón AJ, Pérez-Méndez OA, Sánchez MLO, Segura Y, Tusié MT, Aguilar-Salinas CA. Mehta R, et al. Lipids Health Dis. 2021 Jul 13;20(1):70. doi: 10.1186/s12944-021-01498-6. Lipids Health Dis. 2021. PMID: 34256778 Free PMC article.
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, familial LCAT deficiency (FLD) and Fish Eye disease (FED). This is the first systematic review evaluating the ethnic distribution of LCAT defici …
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, familial LCAT defi …
Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.
Calabresi L, Simonelli S, Gomaraschi M, Franceschini G. Calabresi L, et al. Atherosclerosis. 2012 Jun;222(2):299-306. doi: 10.1016/j.atherosclerosis.2011.11.034. Epub 2011 Nov 28. Atherosclerosis. 2012. PMID: 22189200 Review.
The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized b …
The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a cr …
Very low HDL levels: clinical assessment and management.
Bonilha I, Luchiari B, Nadruz W, Sposito AC. Bonilha I, et al. Arch Endocrinol Metab. 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. Arch Endocrinol Metab. 2023. PMID: 36651718 Free PMC article. Review.
In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and familial hypoalphalipoproteinemia, there is an increased risk of premature atherosclerosis. ...
In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and famil …
Analysis of familial hypoalphalipoproteinemia syndromes.
Frohlich J, Pritchard PH. Frohlich J, et al. Mol Cell Biochem. 1992 Aug 18;113(2):141-9. doi: 10.1007/BF00231534. Mol Cell Biochem. 1992. PMID: 1518505 Review.
Two specific HAs are discussed in this report: 1. primary isolated HA (PIHA) is a poorly characterized entity with an apparent autosomal dominant transmission and distinct abnormalities in the structure and function of HDL. 2. Lecithin: cholesterol acyltransferase (LCAT) …
Two specific HAs are discussed in this report: 1. primary isolated HA (PIHA) is a poorly characterized entity with an apparent autosomal dom …
Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJ. Glukhova A, et al. Nat Commun. 2015 Mar 2;6:6250. doi: 10.1038/ncomms7250. Nat Commun. 2015. PMID: 25727495 Free PMC article.
Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. Here we describe several high-resolution crystal structures of human LPLA2 and a low-resolution st …
Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease an …
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes.
Kuivenhoven JA, Pritchard H, Hill J, Frohlich J, Assmann G, Kastelein J. Kuivenhoven JA, et al. J Lipid Res. 1997 Feb;38(2):191-205. J Lipid Res. 1997. PMID: 9162740 Free article. Review.
Lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes represent a group of rare genetic disorders of HDL metabolism that have been the subject of a large number of clinical, biochemical, and genetic studies. ...In this review, we describe 36 natural mutat …
Lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes represent a group of rare genetic disorders of HDL metabolism …
47 results