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Quoted phrase not found in phrase index: "Lamina lucida cleavage"
Page 1
Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in vivo in Severe Kidney Disease: An Open-Label Phase 2a Study.
Uhlin F, Szpirt W, Kronbichler A, Bruchfeld A, Soveri I, Rostaing L, Daugas E, Lionet A, Kamar N, Rafat C, Mysliveček M, Tesař V, Fernström A, Kjellman C, Elfving C, McAdoo S, Mölne J, Bajema I, Sonesson E, Segelmark M. Uhlin F, et al. J Am Soc Nephrol. 2022 Apr;33(4):829-838. doi: 10.1681/ASN.2021111460. Epub 2022 Mar 8. J Am Soc Nephrol. 2022. PMID: 35260419 Free PMC article. Clinical Trial.
BACKGROUND: The prognosis for kidney survival is poor in patients presenting with circulating anti-glomerular basement membrane (GBM) antibodies and severe kidney injury. It is unknown if treatment with an endopeptidase that cleaves circulating and kidney bound IgG …
BACKGROUND: The prognosis for kidney survival is poor in patients presenting with circulating anti-glomerular basement membrane …
Aliskiren inhibits renin-mediated complement activation.
Békássy ZD, Kristoffersson AC, Rebetz J, Tati R, Olin AI, Karpman D. Békássy ZD, et al. Kidney Int. 2018 Oct;94(4):689-700. doi: 10.1016/j.kint.2018.04.004. Epub 2018 Jun 5. Kidney Int. 2018. PMID: 29884545 Free article.
Renin-mediated C3 cleavage and its inhibition by aliskiren also occurred in serum. Generation of C3 cleavage products was demonstrated by immunoblotting, detecting the cleavage product C3b, by N-terminal sequencing of the cleavage product, and by ELISA …
Renin-mediated C3 cleavage and its inhibition by aliskiren also occurred in serum. Generation of C3 cleavage products was demo …
From Molecular Insights to Clinical Perspectives in Drug-Associated Bullous Pemphigoid.
de Nicolas-Ruanes B, Ballester-Martinez A, Garcia-Mouronte E, Berna-Rico E, Azcarraga-Llobet C, Fernandez-Guarino M. de Nicolas-Ruanes B, et al. Int J Mol Sci. 2023 Nov 26;24(23):16786. doi: 10.3390/ijms242316786. Int J Mol Sci. 2023. PMID: 38069109 Free PMC article. Review.
Bullous pemphigoid (BP), the most common autoimmune blistering disease, is characterized by the presence of autoantibodies targeting BP180 and BP230 in the basement membrane zone. This leads to the activation of complement-dependent and independent pathways, resulti …
Bullous pemphigoid (BP), the most common autoimmune blistering disease, is characterized by the presence of autoantibodies targeting BP180 a …
Matrix metalloproteinases and angiogenesis.
Rundhaug JE. Rundhaug JE. J Cell Mol Med. 2005 Apr-Jun;9(2):267-85. doi: 10.1111/j.1582-4934.2005.tb00355.x. J Cell Mol Med. 2005. PMID: 15963249 Free PMC article. Review.
Angiogenesis is the process of forming new blood vessels from existing ones and requires degradation of the vascular basement membrane and remodeling of the ECM in order to allow endothelial cells to migrate and invade into the surrounding tissue. MMPs participate i …
Angiogenesis is the process of forming new blood vessels from existing ones and requires degradation of the vascular basement memb …
Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.
Turner CT, Zeglinski MR, Richardson KC, Santacruz S, Hiroyasu S, Wang C, Zhao H, Shen Y, Sehmi R, Lima H, Gauvreau GM, Granville DJ. Turner CT, et al. J Invest Dermatol. 2021 Jan;141(1):36-47. doi: 10.1016/j.jid.2020.05.095. Epub 2020 Jun 3. J Invest Dermatol. 2021. PMID: 32504614 Free article. Review.
Long regarded as a pro-apoptotic protease, emerging studies indicate granzyme B (GzmB) to have extracellular roles involving the proteolytic cleavage of extracellular matrix, cell adhesion proteins, and basement membrane proteins. ...Mechanistically, GzmB imp …
Long regarded as a pro-apoptotic protease, emerging studies indicate granzyme B (GzmB) to have extracellular roles involving the proteolytic …
Current understanding of the mechanism of HPV infection.
Schiller JT, Day PM, Kines RC. Schiller JT, et al. Gynecol Oncol. 2010 Jun;118(1 Suppl):S12-7. doi: 10.1016/j.ygyno.2010.04.004. Gynecol Oncol. 2010. PMID: 20494219 Free PMC article. Review.
Rather it must first bind via its L1 major capsid protein to heparan sulfate proteoglycans (HSPGs) on segments of the basement membrane (BM) exposed after epithelial trauma and undergo a conformational change that exposes the N-terminus of L2 minor capsid protein to …
Rather it must first bind via its L1 major capsid protein to heparan sulfate proteoglycans (HSPGs) on segments of the basement mem …
A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D, Simmonds J, Lieu KG, de Souza MJ, Mischnik M, Taylor S, Ow SY, Spycher M, Butcher RE, Pearse M, Zuercher AW, Baz Morelli A, Panousis C, Wilson MJ, Rowe T, Hardy MP. Wymann S, et al. J Biol Chem. 2021 Jan-Jun;296:100200. doi: 10.1074/jbc.RA120.016127. Epub 2020 Dec 23. J Biol Chem. 2021. PMID: 33334893 Free PMC article.
Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b and C4b. ...The …
Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane …
Pulse dye and other laser treatments for vocal scar.
Prufer N, Woo P, Altman KW. Prufer N, et al. Curr Opin Otolaryngol Head Neck Surg. 2010 Dec;18(6):492-7. doi: 10.1097/MOO.0b013e32833f890d. Curr Opin Otolaryngol Head Neck Surg. 2010. PMID: 20842035 Review.
PURPOSE OF REVIEW: Vocal fold scar is a challenging clinical problem, resulting in a spectrum of voice-related complaints. ...Some experimental models describe potential mechanisms of laser effect, which include the development of a sub-basement membrane c …
PURPOSE OF REVIEW: Vocal fold scar is a challenging clinical problem, resulting in a spectrum of voice-related complaints. ...Some ex …
Ultrastructure of the posterior corneal stroma.
Schlötzer-Schrehardt U, Bachmann BO, Tourtas T, Torricelli AA, Singh A, González S, Mei H, Deng SX, Wilson SE, Kruse FE. Schlötzer-Schrehardt U, et al. Ophthalmology. 2015 Apr;122(4):693-9. doi: 10.1016/j.ophtha.2014.09.037. Epub 2014 Nov 18. Ophthalmology. 2015. PMID: 25458195
MAIN OUTCOME MEASURES: The distance of keratocytes to Descemet's membrane, number of collagen lamellae between keratocytes and Descemet's membrane, diameter and arrangement of collagen fibrils, thickness of stromal lamella created by air injection, and immunopositiv …
MAIN OUTCOME MEASURES: The distance of keratocytes to Descemet's membrane, number of collagen lamellae between keratocytes and Descem …
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I. Barash U, et al. FEBS J. 2010 Oct;277(19):3890-903. doi: 10.1111/j.1742-4658.2010.07799.x. Epub 2010 Aug 31. FEBS J. 2010. PMID: 20840586 Free PMC article. Review.
Importantly, heparanase activity correlates with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remodeling of the extracellular matrix and basement membrane underlyin …
Importantly, heparanase activity correlates with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination …
26 results