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Year Number of Results
1946 1
1947 1
1982 1
1983 1
1984 1
1985 3
1986 2
1987 1
1989 2
1990 1
1991 2
1992 2
1993 3
1994 5
1995 41
1996 259
1997 537
1998 748
1999 902
2000 1085
2001 1190
2002 1254
2003 1394
2004 1515
2005 1643
2006 1783
2007 1861
2008 2002
2009 2056
2010 2223
2011 2223
2012 2265
2013 2481
2014 2549
2015 2464
2016 2278
2017 2286
2018 2157
2019 2039
2020 2151
2021 2183
2022 1963
2023 1771
2024 722

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44,258 results

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Page 1
Leptin and Obesity: Role and Clinical Implication.
Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, Gojobori T, Isenovic ER. Obradovic M, et al. Front Endocrinol (Lausanne). 2021 May 18;12:585887. doi: 10.3389/fendo.2021.585887. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34084149 Free PMC article. Review.
Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). ...Often this leads to obesity, which reduces the effectiveness of usi …
Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to an …
Leptin Function and Regulation.
Zhang Y, Chua S Jr. Zhang Y, et al. Compr Physiol. 2017 Dec 12;8(1):351-369. doi: 10.1002/cphy.c160041. Compr Physiol. 2017. PMID: 29357132 Review.
We summarize the biological impact of leptin signaling as well as the molecular and cellular characteristics of leptin action. ...The molecular targets of leptin's effects are also responsible for the attenuation and termination of the intracellular signal tr …
We summarize the biological impact of leptin signaling as well as the molecular and cellular characteristics of leptin action. …
The Leptin Resistance.
Liu J, Yang X, Yu S, Zheng R. Liu J, et al. Adv Exp Med Biol. 2018;1090:145-163. doi: 10.1007/978-981-13-1286-1_8. Adv Exp Med Biol. 2018. PMID: 30390289 Review.
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. ...Leptin resistance is a challenge for clinical treatment or drug discovery of obesity. ...
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. ... …
Structure, production and signaling of leptin.
Münzberg H, Morrison CD. Münzberg H, et al. Metabolism. 2015 Jan;64(1):13-23. doi: 10.1016/j.metabol.2014.09.010. Epub 2014 Sep 28. Metabolism. 2015. PMID: 25305050 Free PMC article. Review.
From the first discovery of the leptin deficient obese mouse (ob/ob), to the cloning of leptin (ob aka lep) and leptin receptor (db aka lepr) genes, much has been learned about leptin and its action in the central nervous system. The initial high hopes …
From the first discovery of the leptin deficient obese mouse (ob/ob), to the cloning of leptin (ob aka lep) and leptin …
Leptin in Tumor Microenvironment.
Angelucci A, Clementi L, Alesse E. Angelucci A, et al. Adv Exp Med Biol. 2020;1259:89-112. doi: 10.1007/978-3-030-43093-1_6. Adv Exp Med Biol. 2020. PMID: 32578173 Review.
These emerging peripheral roles let hypothesize that leptin can modulate also cancer progression. Indeed, many studies have demonstrated that elevated chronic serum concentrations of leptin, frequently seen in obese subjects, represent a stimulatory signal for tumor …
These emerging peripheral roles let hypothesize that leptin can modulate also cancer progression. Indeed, many studies have demonstra …
Leptin-Activity Modulators and Their Potential Pharmaceutical Applications.
Greco M, De Santo M, Comandè A, Belsito EL, Andò S, Liguori A, Leggio A. Greco M, et al. Biomolecules. 2021 Jul 16;11(7):1045. doi: 10.3390/biom11071045. Biomolecules. 2021. PMID: 34356668 Free PMC article. Review.
Both leptin excess and leptin deficiency, as well as leptin resistance, are correlated with different human pathologies, such as autoimmune diseases and cancers, making leptin and leptin receptor important drug targets. ...In the present manuscr …
Both leptin excess and leptin deficiency, as well as leptin resistance, are correlated with different human pathologies …
Gastric Leptin and Tumorigenesis: Beyond Obesity.
Inagaki-Ohara K. Inagaki-Ohara K. Int J Mol Sci. 2019 May 28;20(11):2622. doi: 10.3390/ijms20112622. Int J Mol Sci. 2019. PMID: 31141984 Free PMC article. Review.
Obesity induces abundant leptin production, however, reduced sensitivity to leptin leads to the development of metabolic disorders, so called leptin resistance. ...While the underlying pathomechanisms remain unclear, leptin signaling can affect gastric …
Obesity induces abundant leptin production, however, reduced sensitivity to leptin leads to the development of metabolic disor …
Leptin as a predictive marker for metabolic syndrome.
Ghadge AA, Khaire AA. Ghadge AA, et al. Cytokine. 2019 Sep;121:154735. doi: 10.1016/j.cyto.2019.154735. Epub 2019 May 30. Cytokine. 2019. PMID: 31154250 Review.
Contemporary research suggests that leptin also influences insulin sensitivity and lipid metabolism. High leptin concentrations are directly associated with the obesity subsequent development of metabolic disease sequelae such as insulin resistance, type 2 diabetes …
Contemporary research suggests that leptin also influences insulin sensitivity and lipid metabolism. High leptin concentration …
Leptin regulation of hippocampal synaptic function in health and disease.
Hamilton K, Harvey J. Hamilton K, et al. Vitam Horm. 2021;115:105-127. doi: 10.1016/bs.vh.2020.12.006. Epub 2021 Jan 30. Vitam Horm. 2021. PMID: 33706945 Review.
It is widely accepted that the metabolic hormone leptin regulates food intake and body weight via activation of hypothalamic leptin receptors. ...Increasing evidence from cellular and behavioral studies examining leptin action at CA1 synapses support the noti …
It is widely accepted that the metabolic hormone leptin regulates food intake and body weight via activation of hypothalamic lepti …
Leptin in inflammation and autoimmunity.
La Cava A. La Cava A. Cytokine. 2017 Oct;98:51-58. doi: 10.1016/j.cyto.2016.10.011. Cytokine. 2017. PMID: 27916613 Free PMC article. Review.
After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response. This review analyzes the known implications of lepti …
After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions i …
44,258 results
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