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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1985 1
1993 1
1994 1
1995 4
1996 43
1997 68
1998 126
1999 136
2000 207
2001 250
2002 237
2003 247
2004 278
2005 297
2006 347
2007 288
2008 319
2009 279
2010 316
2011 263
2012 298
2013 339
2014 362
2015 341
2016 280
2017 303
2018 304
2019 299
2020 295
2021 347
2022 298
2023 305
2024 101

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2,705 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Page 1
Leptin and Obesity: Role and Clinical Implication.
Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, Gojobori T, Isenovic ER. Obradovic M, et al. Front Endocrinol (Lausanne). 2021 May 18;12:585887. doi: 10.3389/fendo.2021.585887. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34084149 Free PMC article. Review.
Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). ...Often this leads to obesity, which reduces the effectiveness of usi …
Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to an …
Leptin Function and Regulation.
Zhang Y, Chua S Jr. Zhang Y, et al. Compr Physiol. 2017 Dec 12;8(1):351-369. doi: 10.1002/cphy.c160041. Compr Physiol. 2017. PMID: 29357132 Review.
We summarize the biological impact of leptin signaling as well as the molecular and cellular characteristics of leptin action. ...The molecular targets of leptin's effects are also responsible for the attenuation and termination of the intracellular signal tr …
We summarize the biological impact of leptin signaling as well as the molecular and cellular characteristics of leptin action. …
Adiponectin, Leptin and Cardiovascular Disorders.
Zhao S, Kusminski CM, Scherer PE. Zhao S, et al. Circ Res. 2021 Jan 8;128(1):136-149. doi: 10.1161/CIRCRESAHA.120.314458. Epub 2021 Jan 7. Circ Res. 2021. PMID: 33411633 Free PMC article. Review.
Insufficient adiponectin and leptin signaling results in cardiovascular dysfunction. However, a paradox of high levels of both leptin and adiponectin is emerging in the pathogenesis of cardiovascular disorders. Here, we (1) summarize the recent progress in the field …
Insufficient adiponectin and leptin signaling results in cardiovascular dysfunction. However, a paradox of high levels of both lep …
Leptin and obesity.
Seth M, Biswas R, Ganguly S, Chakrabarti N, Chaudhuri AG. Seth M, et al. Physiol Int. 2020 Dec 22;107(4):455-468. doi: 10.1556/2060.2020.00038. Physiol Int. 2020. PMID: 33355539 Review.
In obesity an excessive amount of fat accumulates in adipose tissue cells as well as in other vital organs like liver, muscles, and pancreas. The adipocytes contain ob genes and express leptin, a 16 kDa protein. In the present communication, we reviewed the molecular basis …
In obesity an excessive amount of fat accumulates in adipose tissue cells as well as in other vital organs like liver, muscles, and pancreas …
Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.
Pereira S, Cline DL, Glavas MM, Covey SD, Kieffer TJ. Pereira S, et al. Endocr Rev. 2021 Jan 28;42(1):1-28. doi: 10.1210/endrev/bnaa027. Endocr Rev. 2021. PMID: 33150398 Free PMC article. Review.
However, the effects of leptin are more far-reaching and include profound glucose-lowering and anti-lipogenic effects, independent of leptin's regulation of body weight. ...To fully understand the role of leptin in physiology and to maximize its therapeutic p …
However, the effects of leptin are more far-reaching and include profound glucose-lowering and anti-lipogenic effects, independent of …
Leptin in Leanness and Obesity: JACC State-of-the-Art Review.
Perakakis N, Farr OM, Mantzoros CS. Perakakis N, et al. J Am Coll Cardiol. 2021 Feb 16;77(6):745-760. doi: 10.1016/j.jacc.2020.11.069. J Am Coll Cardiol. 2021. PMID: 33573745 Free PMC article. Review.
Leptin is considered an important regulator of both neuroendocrine function and energy homeostasis. ...The authors discuss the similarities and discrepancies between animal and human biology and present clinical applications of leptin, directions for future research …
Leptin is considered an important regulator of both neuroendocrine function and energy homeostasis. ...The authors discuss the simila …
The Leptin Resistance.
Liu J, Yang X, Yu S, Zheng R. Liu J, et al. Adv Exp Med Biol. 2018;1090:145-163. doi: 10.1007/978-981-13-1286-1_8. Adv Exp Med Biol. 2018. PMID: 30390289 Review.
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. ...Leptin resistance is a challenge for clinical treatment or drug discovery of obesity. ...
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. ... …
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Izquierdo AG, et al. Nutrients. 2019 Nov 8;11(11):2704. doi: 10.3390/nu11112704. Nutrients. 2019. PMID: 31717265 Free PMC article. Review.
However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic effects in obese individuals, and therefore, the lack of …
However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous admini …
The Importance of Leptin to Reproduction.
Childs GV, Odle AK, MacNicol MC, MacNicol AM. Childs GV, et al. Endocrinology. 2021 Feb 1;162(2):bqaa204. doi: 10.1210/endocr/bqaa204. Endocrinology. 2021. PMID: 33165520 Free PMC article. Review.
In males, the prepubertal rise in leptin promotes testicular development. However, a decline in leptin levels in prepubertal boys reflects inhibition of leptin secretion by rising androgens. In adult males, leptin levels are 10% to 50% of those in fema …
In males, the prepubertal rise in leptin promotes testicular development. However, a decline in leptin levels in prepubertal b …
Leptin and the endocrine control of energy balance.
Friedman JM. Friedman JM. Nat Metab. 2019 Aug;1(8):754-764. doi: 10.1038/s42255-019-0095-y. Epub 2019 Aug 12. Nat Metab. 2019. PMID: 32694767 Review.
In this Review, the biology of leptin is summarized, and a conceptual framework is established for studying the pathogenesis of obesity, which, analogously to diabetes, can result from either leptin hyposecretion or leptin resistance. Herein, these two states …
In this Review, the biology of leptin is summarized, and a conceptual framework is established for studying the pathogenesis of obesi …
2,705 results