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Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database.
Doneddu PE, Cocito D, Manganelli F, Fazio R, Briani C, Filosto M, Benedetti L, Mazzeo A, Marfia GA, Cortese A, Fierro B, Jann S, Beghi E, Clerici AM, Carpo M, Schenone A, Luigetti M, Lauria G, Antonini G, Rosso T, Siciliano G, Cavaletti G, Liberatore G, Santoro L, Peci E, Tronci S, Ruiz M, Cotti Piccinelli S, Toscano A, Mataluni G, Piccolo L, Cosentino G, Sabatelli M, Nobile-Orazio E; Italian CIDP Database study group. Doneddu PE, et al. J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):125-132. doi: 10.1136/jnnp-2018-318714. Epub 2018 Oct 8. J Neurol Neurosurg Psychiatry. 2019. PMID: 30297520 Free article.
RESULTS: At the time of inclusion, 376 (82%) patients had a diagnosis of typical CIDP while 84 (18%) had atypical CIDP, including 34 (7%) with distal acquired demyelinating symmetric neuropathy (DADS), 17 (4%) with purely motor, 17 (4%) with Lewis-Sumner syndrome …
RESULTS: At the time of inclusion, 376 (82%) patients had a diagnosis of typical CIDP while 84 (18%) had atypical CIDP, including 34 (7%) wi …
Motor conduction block and conduction velocity in Lewis-Sumner syndrome and multifocal motor neuropathy.
Li Y, Niu J, Liu T, Guan Y, Wu S, Ding Q, Cui L, Liu M. Li Y, et al. J Clin Neurosci. 2019 Sep;67:10-13. doi: 10.1016/j.jocn.2019.06.044. Epub 2019 Jul 1. J Clin Neurosci. 2019. PMID: 31272830
Motor conduction blocks (CBs) and decreased motor nerve conduction velocity (MCV) are both demyelination electrophysiological characteristics. Though CBs are both common in Lewis-Sumner syndrome (LSS) and multifocal motor neuropathy (MMN), they are two distin …
Motor conduction blocks (CBs) and decreased motor nerve conduction velocity (MCV) are both demyelination electrophysiological characteristic …
Comparison of Lewis-Sumner syndrome with chronic inflammatory demyelinating polyradiculoneuropathy patients in a tertiary care centre.
Fargeot G, Maisonobe T, Psimaras D, Debs R, Lenglet T, Adams D, Vandendries C, Labeyrie C, Viala K. Fargeot G, et al. Eur J Neurol. 2020 Mar;27(3):522-528. doi: 10.1111/ene.14101. Epub 2019 Oct 24. Eur J Neurol. 2020. PMID: 31574194
BACKGROUND AND PURPOSE: Whether the Lewis-Sumner syndrome (L-SS) is a distinct entity from other types of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP-ot) remains controversial. ...
BACKGROUND AND PURPOSE: Whether the Lewis-Sumner syndrome (L-SS) is a distinct entity from other types of chronic infla …
Lewis-Sumner syndrome in a patient with rheumatoid arthritis: Link between rheumatoid arthritis and demyelinating polyradiculoneuropathies.
Kedra J, Foltz V, Viala K, Tan S, Fautrel B. Kedra J, et al. Joint Bone Spine. 2017 Jul;84(4):485-487. doi: 10.1016/j.jbspin.2017.02.013. Epub 2017 Mar 28. Joint Bone Spine. 2017. PMID: 28363822
Chronic inflammatory demyelinating polyradiculoneuropathies are a group of autoimmune neuropathies with a chronic course. Lewis-Sumner syndrome is a variant of this disease, characterized by an asymmetrical distal and mostly motor involvement, predominating a …
Chronic inflammatory demyelinating polyradiculoneuropathies are a group of autoimmune neuropathies with a chronic course. Lewis-Su …
Lewis-Sumner syndrome and multifocal motor neuropathy.
Verschueren A, Azulay JP, Attarian S, Boucraut J, Pellissier JF, Pouget J. Verschueren A, et al. Muscle Nerve. 2005 Jan;31(1):88-94. doi: 10.1002/mus.20236. Muscle Nerve. 2005. PMID: 15536613
We compared the clinical, electrophysiological, laboratory, and pathological features of 13 patients with Lewis-Sumner syndrome (LSS) with those of 20 patients with multifocal motor neuropathy (MMN). ...
We compared the clinical, electrophysiological, laboratory, and pathological features of 13 patients with Lewis-Sumner synd …
Response to treatment in patients with Lewis-Sumner syndrome.
Attarian S, Verschueren A, Franques J, Salort-Campana E, Jouve E, Pouget J. Attarian S, et al. Muscle Nerve. 2011 Aug;44(2):179-84. doi: 10.1002/mus.22024. Muscle Nerve. 2011. PMID: 21755505
INTRODUCTION: Our aim was to document the classification of Lewis-Sumner syndrome (L-SS) based on the response to treatment and the pattern of progression over time. ...
INTRODUCTION: Our aim was to document the classification of Lewis-Sumner syndrome (L-SS) based on the response to treat …
Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome.
Viala K, Renié L, Maisonobe T, Béhin A, Neil J, Léger JM, Bouche P. Viala K, et al. Brain. 2004 Sep;127(Pt 9):2010-7. doi: 10.1093/brain/awh222. Epub 2004 Aug 2. Brain. 2004. PMID: 15289267
Lewis-Sumner syndrome (LSS) is a dysimmune peripheral nerve disorder, characterized by a predominantly distal, asymmetric weakness mostly affecting the upper limbs with sensory impairment, and by the presence of multifocal persistent conduction blocks. ...
Lewis-Sumner syndrome (LSS) is a dysimmune peripheral nerve disorder, characterized by a predominantly distal, asymmetr …
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies.
Zhou XJ, Zhu Y, Zhu DS, Han L, Liu QY, Liang XN, Hao Y, Li ZZ, Guan YT. Zhou XJ, et al. Chin Med J (Engl). 2020 Nov 5;133(21):2558-2564. doi: 10.1097/CM9.0000000000001073. Chin Med J (Engl). 2020. PMID: 32947359 Free PMC article.
BACKGROUND: Multifocal motor neuropathy (MMN), Lewis-Sumner syndrome (LSS), and many chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs) are representative of acquired multifocal polyneuropathy and are characterized by conduction block (CB). . …
BACKGROUND: Multifocal motor neuropathy (MMN), Lewis-Sumner syndrome (LSS), and many chronic inflammatory demyelinating …
Atypical chronic inflammatory demyelinating polyradiculoneuropathy: recent advances on classification, diagnosis, and pathogenesis.
Doneddu PE, Dentoni M, Nobile-Orazio E. Doneddu PE, et al. Curr Opin Neurol. 2021 Oct 1;34(5):613-624. doi: 10.1097/WCO.0000000000000979. Curr Opin Neurol. 2021. PMID: 34267052 Free PMC article. Review.
Recent studies suggest that patients with typical CIDP have an antibody-mediated mechanism of neuropathy whereas in those with Lewis--Sumner syndrome (LSS) neuropathy is preferentially mediated by macrophages and T cells. ...
Recent studies suggest that patients with typical CIDP have an antibody-mediated mechanism of neuropathy whereas in those with Lewis- …
Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies.
Herraets IJT, Goedee HS, Telleman JA, van Eijk RPA, van Asseldonk JT, Visser LH, van den Berg LH, van der Pol WL. Herraets IJT, et al. Neurology. 2020 Apr 7;94(14):e1470-e1479. doi: 10.1212/WNL.0000000000008978. Epub 2020 Jan 20. Neurology. 2020. PMID: 31959710
OBJECTIVE: To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome …
OBJECTIVE: To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion …
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