Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.
Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr, Lozano AM, Penn RD, Simpson RK Jr, Stacy M, Wooten GF; ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor.
Nutt JG, et al.
Neurology. 2003 Jan 14;60(1):69-73. doi: 10.1212/wnl.60.1.69.
Neurology. 2003.
PMID: 12525720
Clinical Trial.
It improved 6-OHDA- or MPTP-induced behavioral deficits in rodents and monkeys. METHODS: A multicenter, randomized, double-blind, placebo-controlled, sequential cohort study compared the effects of monthly ICV administration of placebo and 25, 75, 150, 300, and 500 to 4,00 …
It improved 6-OHDA- or MPTP-induced behavioral deficits in rodents and monkeys. METHODS: A multicenter, randomized, double-blind, pla …