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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 1
1994 4
1995 1
1996 3
1997 1
1998 1
1999 1
2000 3
2001 2
2002 2
2003 1
2004 1
2005 3
2006 5
2007 8
2008 3
2009 4
2010 6
2011 2
2012 3
2013 3
2014 6
2015 4
2016 2
2017 7
2018 5
2019 3
2020 12
2021 6
2022 6
2023 3
2024 2

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105 results

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Page 1
Pediatric adrenocortical carcinoma.
Ilanchezhian M, Varghese DG, Glod JW, Reilly KM, Widemann BC, Pommier Y, Kaplan RN, Del Rivero J. Ilanchezhian M, et al. Front Endocrinol (Lausanne). 2022 Oct 31;13:961650. doi: 10.3389/fendo.2022.961650. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36387865 Free PMC article. Review.
The incidence of pediatric ACC is 10-15fold higher in southern Brazil due to a higher prevalence of TP53 mutation associated with Li-Fraumeni syndrome in that population. Current treatment protocols are derived from adult ACC and consist of surgery and/or che …
The incidence of pediatric ACC is 10-15fold higher in southern Brazil due to a higher prevalence of TP53 mutation associated with Li- …
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T. Kiseljak-Vassiliades K, et al. Endocr Pract. 2020 Nov;26(11):1366-1383. doi: 10.4158/DSCR-2020-0567. Epub 2020 Dec 14. Endocr Pract. 2020. PMID: 33875173 Free PMC article. Review.
METHODS: This is a case-based clinical review. The provided recommendations are based on evidence available from randomized prospective clinical studies, cohort studies, cross-sectional and case-based studies, and expert opinions. ...ABBREVIATIONS: ACC = adre …
METHODS: This is a case-based clinical review. The provided recommendations are based on evidence available from randomized pr …
Osteosarcoma.
Gorlick R, Khanna C. Gorlick R, et al. J Bone Miner Res. 2010 Apr;25(4):683-91. doi: 10.1002/jbmr.77. J Bone Miner Res. 2010. PMID: 20205169 Free article.
Interestingly, several human genetic disorders and familial cancer syndromes, such as Li-Fraumeni syndrome, are linked to an increased risk of osteosarcoma. ...
Interestingly, several human genetic disorders and familial cancer syndromes, such as Li-Fraumeni syndrome, are linked …
BRCA1/P53: Two strengths in cancer chemoprevention.
Raimundo L, Ramos H, Loureiro JB, Calheiros J, Saraiva L. Raimundo L, et al. Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188339. doi: 10.1016/j.bbcan.2020.188339. Epub 2020 Jan 7. Biochim Biophys Acta Rev Cancer. 2020. PMID: 31917206 Review.
Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. ...
Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical succes …
Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.
Zhou R, Xu A, Gingold J, Strong LC, Zhao R, Lee DF. Zhou R, et al. Trends Pharmacol Sci. 2017 Oct;38(10):908-927. doi: 10.1016/j.tips.2017.07.004. Epub 2017 Aug 14. Trends Pharmacol Sci. 2017. PMID: 28818333 Free PMC article. Review.
Li-Fraumeni syndrome (LFS) is a rare hereditary autosomal dominant cancer disorder. ...We discuss the strengths and limitations of current LFS disease models, and touch on existing compounds targeting oncogenic p53 and in vitro clinical trials to devel …
Li-Fraumeni syndrome (LFS) is a rare hereditary autosomal dominant cancer disorder. ...We discuss the strengths and lim …
The etiology of osteosarcoma.
Ottaviani G, Jaffe N. Ottaviani G, et al. Cancer Treat Res. 2009;152:15-32. doi: 10.1007/978-1-4419-0284-9_2. Cancer Treat Res. 2009. PMID: 20213384 Review.
The Li-Fraumeni syndrome is an autosomal dominant disorder characterized by a high risk of developing osteosarcoma and has been found in up to 3% of children with osteosarcoma. It is associated with a germline mutation of the p53, a suppressor gene. The follo …
The Li-Fraumeni syndrome is an autosomal dominant disorder characterized by a high risk of developing osteosarcoma and …
Radiation therapy and secondary malignancy in Li-Fraumeni syndrome: A hereditary cancer registry study.
Hendrickson PG, Luo Y, Kohlmann W, Schiffman J, Maese L, Bishop AJ, Lloyd S, Kokeny KE, Hitchcock YJ, Poppe MM, Gaffney DK, Tao R. Hendrickson PG, et al. Cancer Med. 2020 Nov;9(21):7954-7963. doi: 10.1002/cam4.3427. Epub 2020 Sep 15. Cancer Med. 2020. PMID: 32931654 Free PMC article.
BACKGROUND: Li-Fraumeni Syndrome (LFS) is a rare cancer-predisposing condition caused by germline mutations in TP53. ...
BACKGROUND: Li-Fraumeni Syndrome (LFS) is a rare cancer-predisposing condition caused by germline mutations in TP53. .. …
CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B. Emmerová R, et al. Cesk Patol. 2022 Fall;58(3):150-160. Cesk Patol. 2022. PMID: 36224037 English.
Primary tumors of the central nervous system present 1-2% of all cancers, with a higher incidence in adults after the age of 60, with a slight predominance in men, with higher mortality in men than in women. About 5% of CNS tumors are hereditary (e.g., Li-Fraumeni …
Primary tumors of the central nervous system present 1-2% of all cancers, with a higher incidence in adults after the age of 60, with a slig …
Clinical implications of germline mutations in breast cancer: TP53.
Schon K, Tischkowitz M. Schon K, et al. Breast Cancer Res Treat. 2018 Jan;167(2):417-423. doi: 10.1007/s10549-017-4531-y. Epub 2017 Oct 16. Breast Cancer Res Treat. 2018. PMID: 29039119 Free PMC article. Review.
The optimal surveillance for other cancers is currently unclear and should ideally be performed as part of a clinical trial. CONCLUSIONS: Identifying a TP53 mutation in a gene panel test is a challenging result for the patient and clinician due to the high risk of s …
The optimal surveillance for other cancers is currently unclear and should ideally be performed as part of a clinical trial. C …
Arsenic trioxide extends survival of Li-Fraumeni syndrome mimicking mouse.
Li J, Xiao S, Shi F, Song H, Wu J, Zheng D, Chen X, Tan K, Lu M. Li J, et al. Cell Death Dis. 2023 Nov 29;14(11):783. doi: 10.1038/s41419-023-06281-2. Cell Death Dis. 2023. PMID: 38030599 Free PMC article.
Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. ...Among the ten p53 hotspot mutations in IARC LFS cohorts, R282W is one of the mutations predicting the poorest survival prognosis and the earl …
Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. ...A …
105 results