Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia.
Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller YI.
Liu C, et al.
Dis Model Mech. 2015 Aug 1;8(8):989-98. doi: 10.1242/dmm.019836. Epub 2015 Jun 4.
Dis Model Mech. 2015.
PMID: 26044956
Free PMC article.
Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor for development of cardiovascular disease. …
Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipe …