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Quoted phrase not found in phrase index: "Long QT syndrome 15"
Page 1
Andersen-Tawil Syndrome: A Comprehensive Review.
Pérez-Riera AR, Barbosa-Barros R, Samesina N, Pastore CA, Scanavacca M, Daminello-Raimundo R, de Abreu LC, Nikus K, Brugada P. Pérez-Riera AR, et al. Cardiol Rev. 2021 Jul-Aug 01;29(4):165-177. doi: 10.1097/CRD.0000000000000326. Cardiol Rev. 2021. PMID: 32947483 Review.
Andersen-Tawil syndrome (ATS) is a very rare orphan genetic multisystem channelopathy without structural heart disease (with rare exceptions). ...Prolongation of the QU/QUc intervals and normal or minimally prolonged QT/QTc intervals with a tendency to ventricular a …
Andersen-Tawil syndrome (ATS) is a very rare orphan genetic multisystem channelopathy without structural heart disease (with rare exc …
Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
Kapplinger JD, Giudicessi JR, Ye D, Tester DJ, Callis TE, Valdivia CR, Makielski JC, Wilde AA, Ackerman MJ. Kapplinger JD, et al. Circ Cardiovasc Genet. 2015 Aug;8(4):582-95. doi: 10.1161/CIRCGENETICS.114.000831. Epub 2015 Apr 22. Circ Cardiovasc Genet. 2015. PMID: 25904541 Free PMC article.
METHODS AND RESULTS: Seven in silico tools were used to assign pathogenic/benign status to nsSNVs from 2888 long-QT syndrome cases, 2111 Brugada syndrome cases, and 8975 controls. ...In addition, the in silico tools were assessed for their ability to c …
METHODS AND RESULTS: Seven in silico tools were used to assign pathogenic/benign status to nsSNVs from 2888 long-QT syndrom …
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V. Vandael E, et al. Int J Clin Pharm. 2017 Feb;39(1):16-25. doi: 10.1007/s11096-016-0414-2. Epub 2016 Dec 23. Int J Clin Pharm. 2017. PMID: 28012118 Review.
The following inclusion criteria were applied: randomized controlled trials and observational studies; inclusion of 500 patients from a general population (not limited to specific disease states); assessment of association between QTc-interval and risk factors. ...Results …
The following inclusion criteria were applied: randomized controlled trials and observational studies; inclusion of 500 patients from …
Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing.
Tester DJ, Will ML, Haglund CM, Ackerman MJ. Tester DJ, et al. Heart Rhythm. 2005 May;2(5):507-17. doi: 10.1016/j.hrthm.2005.01.020. Heart Rhythm. 2005. PMID: 15840476
OBJECTIVES: The purpose of this study was to determine the spectrum and prevalence of cardiac channel mutations among a large cohort of consecutive, unrelated patients referred for long QT syndrome (LQTS) genetic testing. BACKGROUND: Congenital LQTS is a prim …
OBJECTIVES: The purpose of this study was to determine the spectrum and prevalence of cardiac channel mutations among a large cohort of cons …
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ. Tisdale JE, et al. Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):479-87. doi: 10.1161/CIRCOUTCOMES.113.000152. Epub 2013 May 28. Circ Cardiovasc Qual Outcomes. 2013. PMID: 23716032 Free PMC article.
Low-, moderate-, and high-risk ranges of 0 to 6, 7 to 10, and 11 to 21 points, respectively, best predicted QTc prolongation (C statistic=0.823). A high-risk score 11 was associated with sensitivity=0.74, specificity=0.77, positive predictive value=0.79, and …
Low-, moderate-, and high-risk ranges of 0 to 6, 7 to 10, and 11 to 21 points, respectively, best predicted QTc prolongation (C stati …
Monogenic and Polygenic Contributions to QTc Prolongation in the Population.
Nauffal V, Morrill VN, Jurgens SJ, Choi SH, Hall AW, Weng LC, Halford JL, Austin-Tse C, Haggerty CM, Harris SL, Wong EK, Alonso A, Arking DE, Benjamin EJ, Boerwinkle E, Min YI, Correa A, Fornwalt BK, Heckbert SR; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium; Kooperberg C, Lin HJ, J F Loos R, Rice KM, Gupta N, Blackwell TW, Mitchell BD, Morrison AC, Psaty BM, Post WS, Redline S, Rehm HL, Rich SS, Rotter JI, Soliman EZ, Sotoodehnia N, Lunetta KL, Ellinor PT, Lubitz SA; TOPMed Investigators. Nauffal V, et al. Circulation. 2022 May 17;145(20):1524-1533. doi: 10.1161/CIRCULATIONAHA.121.057261. Epub 2022 Apr 7. Circulation. 2022. PMID: 35389749 Free PMC article.
BACKGROUND: Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation is restricted to examination of mo …
BACKGROUND: Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval d …
Risk Prediction in Women With Congenital Long QT Syndrome.
Goldenberg I, Bos JM, Yoruk A, Chen AY, Lopes C, Huang DT, Kutyifa V, Younis A, Aktas MK, Z Rosero S, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Scott CG, Briske KA, Sorensen K, J Ackerman M, Zareba W. Goldenberg I, et al. J Am Heart Assoc. 2021 Jul 20;10(14):e021088. doi: 10.1161/JAHA.121.021088. Epub 2021 Jul 9. J Am Heart Assoc. 2021. PMID: 34238014 Free PMC article.
Background We aimed to provide personalized risk estimates for cardiac events (CEs) and life-threatening events in women with either type 1 or type 2 long QT. Methods and Results The prognostic model was derived from the Rochester Long QT Syndrome …
Background We aimed to provide personalized risk estimates for cardiac events (CEs) and life-threatening events in women with either type 1 …
Domperidone and long QT syndrome.
Rossi M, Giorgi G. Rossi M, et al. Curr Drug Saf. 2010 Jul 2;5(3):257-62. doi: 10.2174/157488610791698334. Curr Drug Saf. 2010. PMID: 20394569 Review.
Recently several Regulatory Agencies published safety information on the risk of long QT syndrome associated with the use of domperidone. We conducted a literature review using PubMed (1966 - Jan 2010) with the aim to locate articles on ventricular arrhytmias …
Recently several Regulatory Agencies published safety information on the risk of long QT syndrome associated with the u …
Elucidation of ALG10B as a Novel Long-QT Syndrome-Susceptibility Gene.
Zhou W, Ye D, Tester DJ, Bains S, Giudicessi JR, Haglund-Turnquist CM, Orland KM, January CT, Eckhardt LL, Maginot KR, Ackerman MJ. Zhou W, et al. Circ Genom Precis Med. 2023 Apr;16(2):e003726. doi: 10.1161/CIRCGEN.122.003726. Epub 2023 Feb 22. Circ Genom Precis Med. 2023. PMID: 37071726 Free PMC article.
BACKGROUND: Long-QT syndrome (LQTS) is characterized by QT prolongation and increased risk for syncope, seizures, and sudden cardiac death. ...Therefore, ALG10B is a novel LQTS-susceptibility gene underlying the LQTS phenotype observed in a mult …
BACKGROUND: Long-QT syndrome (LQTS) is characterized by QT prolongation and increased risk for syncope, seizures …
Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.
Lahrouchi N, Tadros R, Crotti L, Mizusawa Y, Postema PG, Beekman L, Walsh R, Hasegawa K, Barc J, Ernsting M, Turkowski KL, Mazzanti A, Beckmann BM, Shimamoto K, Diamant UB, Wijeyeratne YD, Kucho Y, Robyns T, Ishikawa T, Arbelo E, Christiansen M, Winbo A, Jabbari R, Lubitz SA, Steinfurt J, Rudic B, Loeys B, Shoemaker MB, Weeke PE, Pfeiffer R, Davies B, Andorin A, Hofman N, Dagradi F, Pedrazzini M, Tester DJ, Bos JM, Sarquella-Brugada G, Campuzano Ó, Platonov PG, Stallmeyer B, Zumhagen S, Nannenberg EA, Veldink JH, van den Berg LH, Al-Chalabi A, Shaw CE, Shaw PJ, Morrison KE, Andersen PM, Müller-Nurasyid M, Cusi D, Barlassina C, Galan P, Lathrop M, Munter M, Werge T, Ribasés M, Aung T, Khor CC, Ozaki M, Lichtner P, Meitinger T, van Tintelen JP, Hoedemaekers Y, Denjoy I, Leenhardt A, Napolitano C, Shimizu W, Schott JJ, Gourraud JB, Makiyama T, Ohno S, Itoh H, Krahn AD, Antzelevitch C, Roden DM, Saenen J, Borggrefe M, Odening KE, Ellinor PT, Tfelt-Hansen J, Skinner JR, van den Berg MP, Olesen MS, Brugada J, Brugada R, Makita N, Breckpot J, Yoshinaga M, Behr ER, Rydberg A, Aiba T, Kääb S, Priori SG, Guicheney P, Tan HL, Newton-Cheh C, Ackerman MJ, Schwartz PJ, Schulze-Bahr E, Probst V,… See abstract for full author list ➔ Lahrouchi N, et al. Circulation. 2020 Jul 28;142(4):324-338. doi: 10.1161/CIRCULATIONAHA.120.045956. Epub 2020 May 20. Circulation. 2020. PMID: 32429735 Free PMC article.
BACKGROUND: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac death in the young. ...Furthermore, we tested the aggregate effect of the 68 single nucleotide polymorphisms previously associated with the QT …
BACKGROUND: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac death in …
427 results