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Quoted phrase not found in phrase index: "Loss of Chromosome 12q"
Page 1
Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A. Cryns VL, et al. Genes Chromosomes Cancer. 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. Genes Chromosomes Cancer. 1995. PMID: 7541648 Review.
Control leukocyte DNA from all 25 patients was heterozygous for 1 or more of the 9 chromosome 1 markers examined. Allelic loss at 1 or more of these informative loci on chromosome 1 was observed in 10 of 25 (40%) adenomas. ...In contrast, allelic lo …
Control leukocyte DNA from all 25 patients was heterozygous for 1 or more of the 9 chromosome 1 markers examined. Allelic loss …
Molecular changes during the genesis of human gliomas.
Sehgal A. Sehgal A. Semin Surg Oncol. 1998 Jan-Feb;14(1):3-12. doi: 10.1002/(sici)1098-2388(199801/02)14:1<3::aid-ssu2>3.0.co;2-f. Semin Surg Oncol. 1998. PMID: 9407626 Review.
Neoplastic transformation in the normal human brain occurs as a result of the accumulation of a series of genetic alterations. These genetic alterations include the loss, gain or amplification of different chromosomes which lead to altered expression of proteins tha …
Neoplastic transformation in the normal human brain occurs as a result of the accumulation of a series of genetic alterations. These genetic …
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location-dependent patterns of genetic and epigenetic alterations.
Jurmeister P, Wrede N, Hoffmann I, Vollbrecht C, Heim D, Hummel M, Wolkenstein P, Koch I, Heynol V, Schmitt WD, Thieme A, Teichmann D, Sers C, von Deimling A, Thierauf JC, von Laffert M, Klauschen F, Capper D. Jurmeister P, et al. J Pathol. 2022 Jan;256(1):61-70. doi: 10.1002/path.5808. Epub 2021 Oct 25. J Pathol. 2022. PMID: 34564861
Furthermore, all investigated melanomas of the paranasal sinus showed loss of PTEN expression (9/9), mainly caused by promoter methylation. ...Copy number analysis revealed recurrent amplifications in mucosal melanomas, including chromosomes 4q, 5p, 11q and 12q …
Furthermore, all investigated melanomas of the paranasal sinus showed loss of PTEN expression (9/9), mainly caused by promoter methyl …
Dowling-Degos Disease in the Anogenital Region.
Belamarić M, Ljubojević Hadžavdić S. Belamarić M, et al. Acta Dermatovenerol Croat. 2022 Dec;30(4):261-262. Acta Dermatovenerol Croat. 2022. PMID: 36919394
Dowling-Degos disease (DDD) is a benign, rare genodermatosis (reticulate pigmented anomaly) of flexure sites with autosomal dominant inheritance (1,2).The disease is caused by a loss-of-function mutation of keratin 5 (KRT5) present on the chromosome 12q gene …
Dowling-Degos disease (DDD) is a benign, rare genodermatosis (reticulate pigmented anomaly) of flexure sites with autosomal dominant inherit …
Loss of heterozygosity on chromosome 2 in Japanese patients with prostate cancer.
Ueda T, Komiya A, Suzuki H, Shimbo M, Sakamoto S, Imamoto T, Akakura K, Shiraishi T, Ichikawa T. Ueda T, et al. Prostate. 2005 Aug 1;64(3):265-71. doi: 10.1002/pros.20228. Prostate. 2005. PMID: 15717310
BACKGROUND: Loss of heterozygosity (LOH) on chromosome 2 is thought to occur only occasionally in prostate cancer (PCa), but allelic losses in this region are frequent in other types of human cancer, such as lung, thyroid, head and neck, and cervix. ...DNA from norm …
BACKGROUND: Loss of heterozygosity (LOH) on chromosome 2 is thought to occur only occasionally in prostate cancer (PCa), but a …
Reduced penetrance in a large Caucasian pedigree with Stickler syndrome.
Tompson SW, Johnson C, Abbott D, Bakall B, Soler V, Yanovitch TL, Whisenhunt KN, Klemm T, Rozen S, Stone EM, Johnson M, Young TL. Tompson SW, et al. Ophthalmic Genet. 2017 Jan-Feb;38(1):43-50. doi: 10.1080/13816810.2016.1275018. Epub 2017 Jan 17. Ophthalmic Genet. 2017. PMID: 28095098 Free PMC article.
RESULTS: Parametric multipoint linkage analysis using an AD inheritance model demonstrated HLOD scores > 2.00 at chromosomes 1p36.13-1p36.11 and 12q12-12q14.1. SIMWALK multipoint analysis replicated the peak in chromosome 12q (peak LOD = 1.975). FAS …
RESULTS: Parametric multipoint linkage analysis using an AD inheritance model demonstrated HLOD scores > 2.00 at chromosomes …
SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain.
Sinclair PB, Ryan S, Bashton M, Hollern S, Hanna R, Case M, Schwalbe EC, Schwab CJ, Cranston RE, Young BD, Irving JAE, Vora AJ, Moorman AV, Harrison CJ. Sinclair PB, et al. Leukemia. 2019 Aug;33(8):1881-1894. doi: 10.1038/s41375-019-0412-1. Epub 2019 Feb 28. Leukemia. 2019. PMID: 30816328 Free PMC article.
Although frequent, the mechanisms by which these abnormalities promote B-ALL remain obscure. Intriguingly, we found copy number neutral loss of heterozygosity (CN-LOH) of 12q was recurrent in iAMP21-ALL, but never observed in B-ALL without some form of chr …
Although frequent, the mechanisms by which these abnormalities promote B-ALL remain obscure. Intriguingly, we found copy number neutral l …
Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas.
Italiano A, Chambonniere ML, Attias R, Chibon F, Coindre JM, Pedeutour F. Italiano A, et al. Cancer Genet Cytogenet. 2008 Jul 15;184(2):99-104. doi: 10.1016/j.cancergencyto.2008.04.004. Cancer Genet Cytogenet. 2008. PMID: 18617058
In these two cases, we did not identify supernumerary ring or giant chromosomes containing 12q amplification or any other chromosome 12 rearrangement. ...It has been described in myelodysplastic syndromes and acute myeloid or lymphoblastic leukemias, as well …
In these two cases, we did not identify supernumerary ring or giant chromosomes containing 12q amplification or any other c …
Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.
Sunamura M, Oonuma M, Motoi F, Abe H, Saitoh Y, Hoshida T, Ottomo S, Horii A, Matsuno S. Sunamura M, et al. Hum Cell. 2002 Sep;15(3):138-50. doi: 10.1111/j.1749-0774.2002.tb00108.x. Hum Cell. 2002. PMID: 12703544 Review.
Based on these results, we are developing a new gene therapy targeting the genetic character of pancreatic cancer using mutant adenoviruses selectively replication-competent in tumor cells. Loss of heterozygosity (LOH) of 30% or more were observed on chromosome …
Based on these results, we are developing a new gene therapy targeting the genetic character of pancreatic cancer using mutant adenoviruses …
Loss of heterozygosity at chromosome segments 8p22 and 8p11.2-21.1 in transitional-cell carcinoma of the urinary bladder.
Choi C, Kim MH, Juhng SW, Oh BR. Choi C, et al. Int J Cancer. 2000 May 15;86(4):501-5. doi: 10.1002/(sici)1097-0215(20000515)86:4<501::aid-ijc9>3.0.co;2-#. Int J Cancer. 2000. PMID: 10797262 Free article.
To identify the putative tumor-suppressor gene (TSG) involved in transitional-cell carcinoma (TCC) of the urinary bladder, we undertook an allelotyping analysis in 48 cases of TCC. Relatively high percentages of allelic loss were found in 2p (5 of 23, 21.7%), 8p (9 of 21, …
To identify the putative tumor-suppressor gene (TSG) involved in transitional-cell carcinoma (TCC) of the urinary bladder, we undertook an a …
86 results