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Quoted phrase not found in phrase index: "Loss of Chromosome 7q"
Page 1
Splenic marginal zone lymphoma.
Piris MA, Onaindía A, Mollejo M. Piris MA, et al. Best Pract Res Clin Haematol. 2017 Mar-Jun;30(1-2):56-64. doi: 10.1016/j.beha.2016.09.005. Epub 2016 Nov 5. Best Pract Res Clin Haematol. 2017. PMID: 28288718 Review.
Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related with marginal zone differentiation. There is a striking clinical variability in SMZL cases, dependent of the tumoral load and performance stat …
Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related wi …
The genetic and molecular pathogenesis of myelodysplastic syndromes.
Shallis RM, Ahmad R, Zeidan AM. Shallis RM, et al. Eur J Haematol. 2018 Sep;101(3):260-271. doi: 10.1111/ejh.13092. Epub 2018 Jul 12. Eur J Haematol. 2018. PMID: 29742289 Review.
A wide array of recurring genetic mutations involved in RNA splicing, histone manipulation, DNA methylation, transcription factors, kinase signaling, DNA repair, cohesin proteins, and other signal transduction elements has been identified as important substrates for the developme …
A wide array of recurring genetic mutations involved in RNA splicing, histone manipulation, DNA methylation, transcription factors, kinase s …
The molecular pathogenesis of the myelodysplastic syndromes.
Pellagatti A, Boultwood J. Pellagatti A, et al. Eur J Haematol. 2015 Jul;95(1):3-15. doi: 10.1111/ejh.12515. Epub 2015 Feb 20. Eur J Haematol. 2015. PMID: 25645650 Review.
The cytogenetic abnormalities found in MDS are characterized by the loss of genetic material, whereas translocations are rare. The cytogenetic deletion maps of MDS (e.g., 5q-, 7q-, 20q-) provide us with circumstantial evidence for the presence of tumor suppressor ge …
The cytogenetic abnormalities found in MDS are characterized by the loss of genetic material, whereas translocations are rare. The cy …
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.
Davidsson J, Puschmann A, Tedgård U, Bryder D, Nilsson L, Cammenga J. Davidsson J, et al. Leukemia. 2018 May;32(5):1106-1115. doi: 10.1038/s41375-018-0074-4. Epub 2018 Feb 25. Leukemia. 2018. PMID: 29535429 Free PMC article. Review.
In blood cells, additional somatic aberrations that reverse the germline mutation's effect, and give rise to the clonal expansion of cells with reduced or no antiproliferative effect of SAMD9 or SAMD9L include complete or partial chromosome 7 loss or loss-of- …
In blood cells, additional somatic aberrations that reverse the germline mutation's effect, and give rise to the clonal expansion of cells w …
Splenic marginal zone lymphoma.
Oscier D, Owen R, Johnson S. Oscier D, et al. Blood Rev. 2005 Jan;19(1):39-51. doi: 10.1016/j.blre.2004.03.002. Blood Rev. 2005. PMID: 15572216 Review.
There is no genetic abnormality specific for SMZL, but deletions of chromosome 7q are the commonest abnormality and are found in 30-50% of cases. SMZL cells may have either mutated or unmutated immunoglobulin variable region genes and probably arise from different s …
There is no genetic abnormality specific for SMZL, but deletions of chromosome 7q are the commonest abnormality and are found …
Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS.
Ganguly BB, Banerjee D, Agarwal MB. Ganguly BB, et al. Blood Cells Mol Dis. 2018 Mar;69:90-100. doi: 10.1016/j.bcmd.2017.10.001. Epub 2017 Oct 16. Blood Cells Mol Dis. 2018. PMID: 29079134 Review.
The advent of technological development has undoubtedly advanced biological and molecular inputs for better understanding the heterogeneous hematopoietic pre-malignant disorder of the stem cells known as myelodysplastic syndromes (MDS). Chromosomal rearrangements, includin …
The advent of technological development has undoubtedly advanced biological and molecular inputs for better understanding the heterogeneous …
Distinct clinical and biological implications of CUX1 in myeloid neoplasms.
Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, Visconte V, Kuzmanovic T, Adema V, Nazha A, Przychodzen BP, Kerr CM, Sekeres MA, Abazeed ME, Nepveu A, Maciejewski JP. Aly M, et al. Blood Adv. 2019 Jul 23;3(14):2164-2178. doi: 10.1182/bloodadvances.2018028423. Blood Adv. 2019. PMID: 31320321 Free PMC article.
The CUX1 locus is also deleted in 3 of 4 MN cases with -7/del(7q). A cohort of 1480 MN patients was used to characterize clinical features and clonal hierarchy associated with CUX1 (MT) and CUX1 deletions (CUX1 (DEL)) and to analyze their functional consequences in vitro. …
The CUX1 locus is also deleted in 3 of 4 MN cases with -7/del(7q). A cohort of 1480 MN patients was used to characterize clinical fea …
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.
Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes TD, Chiang SCC, Komulainen-Ebrahim J, Gorcenco S, Rundberg Nilsson A, Ripperger T, Kokkonen H, Bryder D, Fioretos T, Henter JI, Möttönen M, Niinimäki R, Nilsson L, Pronk CJ, Puschmann A, Qian H, Uusimaa J, Moilanen J, Tedgård U, Cammenga J, Bryceson YT. Tesi B, et al. Blood. 2017 Apr 20;129(16):2266-2279. doi: 10.1182/blood-2016-10-743302. Epub 2017 Feb 15. Blood. 2017. PMID: 28202457 Free PMC article.
Genetic studies uncovered heterozygous missense mutations in SAMD9L, a tumor suppressor gene located on chromosome arm 7q. Consistent with a gain-of-function effect, ectopic expression of the 2 identified SAMD9L mutants decreased cell proliferation relative to wild- …
Genetic studies uncovered heterozygous missense mutations in SAMD9L, a tumor suppressor gene located on chromosome arm 7q. Con …
Cytogenetic Characteristics of de novo Acute Myeloid Leukemia in Southern Vietnam.
Thao LTT, Ha CT, Ha NTT, Beaupha SMC, Nghia H, Tung TT, Son NT, Binh NT, Dung PC, Vu HA, Xinh PT. Thao LTT, et al. Asian Pac J Cancer Prev. 2023 May 1;24(5):1789-1795. doi: 10.31557/APJCP.2023.24.5.1789. Asian Pac J Cancer Prev. 2023. PMID: 37247302 Free PMC article.
According to French - American - British classification, AML-M2 is the most frequent type with 35.1%. Chromosomal abnormalities were detected in 208 cases, accounting for 61.9%. Among structural abnormalities, t(15;17) was the most common (19.6%), followed by t(8;21) and i …
According to French - American - British classification, AML-M2 is the most frequent type with 35.1%. Chromosomal abnormalities were …
Nodal and splenic marginal zone B cell lymphomas.
Mollejo M, Camacho FI, Algara P, Ruiz-Ballesteros E, García JF, Piris MA. Mollejo M, et al. Hematol Oncol. 2005 Sep-Dec;23(3-4):108-18. doi: 10.1002/hon.762. Hematol Oncol. 2005. PMID: 16307458 Review.
The most frequent molecular alteration found in SMZL is allelic loss at the 7q chromosomal region. SMZL is an indolent lymphoma, although there is small subset of patients in which it follows an aggressive course. ...
The most frequent molecular alteration found in SMZL is allelic loss at the 7q chromosomal region. SMZL is an indolent …
120 results