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Quoted phrase not found in phrase index: "Low density lipoprotein cholesterol level quantitative trait locus 1"
Page 1
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study.
Huang W, Xiao J, Ji J, Chen L. Huang W, et al. Elife. 2021 Dec 6;10:e73873. doi: 10.7554/eLife.73873. Elife. 2021. PMID: 34866576 Free PMC article.
METHODS: We used two kinds of genetic instruments to proxy the exposure of lipid-lowering drugs, including expression quantitative trait loci of drugs target genes, and genetic variants within or nearby drugs target genes associated with low-density …
METHODS: We used two kinds of genetic instruments to proxy the exposure of lipid-lowering drugs, including expression quantitative …
The power of genetic diversity in genome-wide association studies of lipids.
Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Thuesen BH, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesl… See abstract for full author list ➔ Graham SE, et al. Nature. 2021 Dec;600(7890):675-679. doi: 10.1038/s41586-021-04064-3. Epub 2021 Dec 9. Nature. 2021. PMID: 34887591 Free PMC article.
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use(1). Despite advances in prevention and treatment, in particular through reducing low-d …
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different …
Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study.
Ren Z, Zhou L. Ren Z, et al. Inflammopharmacology. 2024 Apr;32(2):1253-1261. doi: 10.1007/s10787-024-01441-y. Epub 2024 Feb 16. Inflammopharmacology. 2024. PMID: 38363475
METHODS: Instrumental variables predicting three cholesterol-lowering target genes (including HGMCR) and the cholesterol effectors mediated by these genes (i.e., total cholesterol, LDL cholesterol, and non-HDL cholesterol) were extracted …
METHODS: Instrumental variables predicting three cholesterol-lowering target genes (including HGMCR) and the cholesterol effec …
Lipoprotein(a): resurrected by genetics.
Kronenberg F, Utermann G. Kronenberg F, et al. J Intern Med. 2013 Jan;273(1):6-30. doi: 10.1111/j.1365-2796.2012.02592.x. Epub 2012 Nov 12. J Intern Med. 2013. PMID: 22998429 Free article. Review.
Plasma lipoprotein(a) [Lp(a)] is a quantitative genetic trait with a very broad and skewed distribution, which is largely controlled by genetic variants at the LPA locus on chromosome 6q27. ...However, it has been established in a proof of principle st …
Plasma lipoprotein(a) [Lp(a)] is a quantitative genetic trait with a very broad and skewed distribution, which is large …
Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.
Almramhi MM, Finan C, Storm CS, Schmidt AF, Kia DA, Coneys R, Chopade S, Hingorani AD, Wood NW. Almramhi MM, et al. Neurology. 2023 Oct 24;101(17):e1729-e1740. doi: 10.1212/WNL.0000000000207777. Epub 2023 Sep 1. Neurology. 2023. PMID: 37657941 Free PMC article.
METHOD: We used two-sample Mendelian randomization (MR) to investigate (1) the causal role of genetically mimic both cholesterol-dependent (through low-density lipoprotein cholesterol (LDL-C) and cholesterol biosynthesis pat …
METHOD: We used two-sample Mendelian randomization (MR) to investigate (1) the causal role of genetically mimic both cholesterol …
Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene.
Fairoozy RH, Cooper J, White J, Giambartolomei C, Folkersen L, Wannamethee SG, Jefferis BJ, Whincup P, Ben-Shlomo Y, Kumari M, Kivimaki M, Wong A, Hardy R, Kuh D, Gaunt TR, Casas JP, McLachlan S, Price JF, Hingorani A, Franco-Cereceda A, Grewal T, Kalea AZ, Humphries SE; UCLEB consortium. Fairoozy RH, et al. Atherosclerosis. 2017 Jun;261:60-68. doi: 10.1016/j.atherosclerosis.2017.04.010. Epub 2017 Apr 13. Atherosclerosis. 2017. PMID: 28456096 Free PMC article.
The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein cholesterol-receptors (LDL-R) and thereby regulate low-density lipoprotein cholesterol (LDL …
The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein …
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease.
Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A. Bindesbøll C, et al. Sci Rep. 2020 Mar 11;10(1):4528. doi: 10.1038/s41598-020-61352-0. Sci Rep. 2020. PMID: 32161285 Free PMC article.
Cellular cholesterol is mainly regulated at the transcriptional level by SREBP2, but also through uptake of extracellular cholesterol from low density lipoproteins (LDL) via expression of LDL receptors (LDLR) at the cell surface. . …
Cellular cholesterol is mainly regulated at the transcriptional level by SREBP2, but also through uptake of extracellular c …
Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol.
Guthrie PA, Rodriguez S, Gaunt TR, Lawlor DA, Smith GD, Day IN. Guthrie PA, et al. Gene. 2012 May 10;499(1):8-13. doi: 10.1016/j.gene.2012.03.034. Epub 2012 Mar 11. Gene. 2012. PMID: 22433445 Free PMC article.
HPR rs2000999 (G/A), identified in meta-GWAS, influences total cholesterol (TC) and LDL-cholesterol (LDL-C). We examined the relationship between HP CNV, HPR rs2000999, Hb, red cell count (RCC), LDL-C and TC in the British Women's Heart and Heal …
HPR rs2000999 (G/A), identified in meta-GWAS, influences total cholesterol (TC) and LDL-cholesterol (LDL-C). We …
Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study.
Bell AS, Rosoff DB, Mavromatis LA, Jung J, Wagner J, Lohoff FW. Bell AS, et al. J Am Heart Assoc. 2022 Nov;11(21):e026122. doi: 10.1161/JAHA.122.026122. Epub 2022 Oct 26. J Am Heart Assoc. 2022. PMID: 36285785 Free PMC article.
Methods and Results Using PCSK9 gene single-nucleotide polymorphisms from European ancestry-based genome-wide association studies of low-density lipoprotein cholesterol (N=1 320 016), circulating PCSK9 protein levels (N=10 186), tissue-sp …
Methods and Results Using PCSK9 gene single-nucleotide polymorphisms from European ancestry-based genome-wide association studies of low …
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.
Theusch E, Chen YI, Rotter JI, Krauss RM, Medina MW. Theusch E, et al. BMC Genomics. 2020 Aug 12;21(1):555. doi: 10.1186/s12864-020-06966-4. BMC Genomics. 2020. PMID: 32787775 Free PMC article.
BACKGROUND: Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Though statins reduce cardiovascular disease risk overall, statin efficacy varies, and some people experience adverse side effects while on sta …
BACKGROUND: Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Tho …
52 results