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Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
Kwon M, Rubio G, Wang H, Riedlinger G, Adem A, Zhong H, Slegowski D, Post-Zwicker L, Chidananda A, Schrump DS, Pine SR, Libutti SK. Kwon M, et al. Cancer Res Commun. 2022 Oct 18;2(10):1197-1213. doi: 10.1158/2767-9764.CRC-22-0233. eCollection 2022 Oct. Cancer Res Commun. 2022. PMID: 36860703 Free PMC article.
SIGNIFICANCE: This study identifies FILIP1L as a tumor suppressor in LUADs and demonstrates that downregulation of FILIP1L is a clinically relevant event in the pathogenesis and clinical course of these neoplasms....
SIGNIFICANCE: This study identifies FILIP1L as a tumor suppressor in LUADs and demonstrates that downregulation of FILIP1L is a clinically r …
An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.
Yamada T, Kondo M, Miyata K, Ogata K, Kushida M, Sumida K, Kawamura S, Osimitz TG, Lake BG, Cohen SM. Yamada T, et al. Toxicol Sci. 2017 Jun 1;157(2):465-486. doi: 10.1093/toxsci/kfx066. Toxicol Sci. 2017. PMID: 28431163
Studies were conducted to determine whether permethrin has mitogenic activity in Club cells in mouse lung as the basis for the mode of action (MOA) for the lung adenoma induction. Several short-term experiments focusing on time-course, dose-response, reversibility, sex dif …
Studies were conducted to determine whether permethrin has mitogenic activity in Club cells in mouse lung as the basis for the mode of actio …
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
Goralczyk R, Bachmann H, Wertz K, Lenz B, Riss G, Buchwald Hunziker P, Greatrix B, Aebischer CP. Goralczyk R, et al. Nutr Cancer. 2006;54(2):252-62. doi: 10.1207/s15327914nc5402_12. Nutr Cancer. 2006. PMID: 16898870
Gene regulation of the putative tumor suppressor RARbeta in mouse lung was analyzed by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for its relevance in predicting the endpoint of lung cancer. A/J-mice achieved plasma beta-carotene levels …
Gene regulation of the putative tumor suppressor RARbeta in mouse lung was analyzed by quantitative real-time reverse transcriptase-polymera …
A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT).
Chen L, Lu Y, Zhao M, Xu J, Wang Y, Xu Q, Cao Y, Liu H. Chen L, et al. J Gene Med. 2024 Jan;26(1):e3612. doi: 10.1002/jgm.3612. Epub 2023 Oct 28. J Gene Med. 2024. PMID: 37897251
RESULTS: ECE1 was upregulated in LUAD and correlated with the poor prognosis of patients with LUAD. Functional studies showed that knockdown of ECE1 retarded the progression of tumors formed by lung cancer cells at least partly by inhibiting tumor cell proliferation. ...
RESULTS: ECE1 was upregulated in LUAD and correlated with the poor prognosis of patients with LUAD. Functional studies showed that kn …
Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells.
Götz R, Sendtner M. Götz R, et al. PLoS One. 2014 Jun 24;9(6):e100944. doi: 10.1371/journal.pone.0100944. eCollection 2014. PLoS One. 2014. PMID: 24959744 Free PMC article.
TrkB receptor signaling is associated with metastasis and poor patient prognosis in NSCLC. Expression of this receptor in A549 cells and in another adenocarcinoma cell line, NCI-H441, promoted enhanced migratory capacity in wound healing assays in the presence of the TrkB …
TrkB receptor signaling is associated with metastasis and poor patient prognosis in NSCLC. Expression of this receptor in A549 cells …
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Wang W, Zhang L, Liu L, Zheng Y, Zhang Y, Yang S, Shi R, Wang S. Wang W, et al. Oncol Rep. 2017 Apr;37(4):1989-1997. doi: 10.3892/or.2017.5443. Epub 2017 Feb 14. Oncol Rep. 2017. PMID: 28260069 Free PMC article.
Progression-free survival was longer in ERCC1-negative lung adenoma patients than those with high ERCC1 levels (30 vs. 11 months, P<0.0001). ERCC1 expression was identified as a prognostic marker for overall survival in the patient cohort with operable lesions. ...
Progression-free survival was longer in ERCC1-negative lung adenoma patients than those with high ERCC1 levels (30 vs. 11 months, P<0.000 …
A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis.
Wang JZ, Xiang JJ, Wu LG, Bai YS, Chen ZW, Yin XQ, Wang Q, Guo WH, Peng Y, Guo H, Xu P. Wang JZ, et al. BMC Cancer. 2017 Mar 3;17(1):167. doi: 10.1186/s12885-017-3151-6. BMC Cancer. 2017. PMID: 28253859 Free PMC article.
In this study, we hypothesized that genetic variant of this lncRNA may affect the prognosis of lung cancer patients. METHODS: We conducted a follow-up study for 538 patients with non-small cell lung carcinoma (NSCLC), including 140 early-staged (stage I and II) and 398 adv …
In this study, we hypothesized that genetic variant of this lncRNA may affect the prognosis of lung cancer patients. METHODS: We cond …
Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia.
Chockalingam AK, Hickman D, Pena L, Ye J, Ferrero A, Echenique JR, Chen H, Sutton T, Perez DR. Chockalingam AK, et al. J Virol. 2012 Apr;86(7):3564-73. doi: 10.1128/JVI.05809-11. Epub 2012 Jan 25. J Virol. 2012. PMID: 22278240 Free PMC article.
Under these circumstances, mice infected with deltaNA viruses were associated with a better prognosis following a secondary bacterial challenge. These data suggest that the H2N2 and H9N2 subtypes of avian influenza A viruses can contribute to secondary bacterial pneumonia …
Under these circumstances, mice infected with deltaNA viruses were associated with a better prognosis following a secondary bacterial …