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Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab.
Correll CK, Miller DD, Maguiness SM. Correll CK, et al. JAMA Dermatol. 2020 May 1;156(5):566-569. doi: 10.1001/jamadermatol.2019.4984. JAMA Dermatol. 2020. PMID: 32049306 Free PMC article.
IMPORTANCE: Childhood-onset lupus erythematosus panniculitis (LEP) is a rare and chronic disfiguring disease. A paucity of literature exists on the clinical manifestations of this disease and how best to treat it. ...DESIGN, SETTING, AND PARTICIPANTS: A retro …
IMPORTANCE: Childhood-onset lupus erythematosus panniculitis (LEP) is a rare and chronic disfiguring disease. A paucity …
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study.
Verdier M, Anuardo P, Gormezano NWS, Romiti R, Campos LMA, Aikawa NE, Pereira RMR, Terreri MT, Magalhães CS, Ferreira JCOA, Silva MFC, Ferriani M, Sakamoto AP, Ferriani VPL, Centeville M, Sato J, Santos MC, Bonfá E, Silva CA. Verdier M, et al. Adv Rheumatol. 2019 Jan 18;59(1):3. doi: 10.1186/s42358-019-0049-9. Adv Rheumatol. 2019. PMID: 30658703

Statistical analysis was performed using Bonferroni correction(p < 0.004). RESULTS: Panniculitis was observed in 6/847(0.7%) cSLE. Painful subcutaneous erythematosus and indurated nodules were observed in 6/6 panniculitis patients and painful subcutaneous plaques

Statistical analysis was performed using Bonferroni correction(p < 0.004). RESULTS: Panniculitis was observed in 6/847(0.7%) cSLE.

Discoid lupus erythematosus lesions developed on lupus erythematosus profundus nodules.
Caproni M, Palleschi GM, Papi C, Fabbri P. Caproni M, et al. Int J Dermatol. 1995 May;34(5):357-9. doi: 10.1111/j.1365-4362.1995.tb03619.x. Int J Dermatol. 1995. PMID: 7607799
The epidermal changes, with the liquefaction degeneration of the basal cell layer, a moderate follicular hyperkeratosis, and a perivascular and periappendeal lymphocytic infiltrate, were also observed in the abdominal lesion that developed last without clinically evident D …
The epidermal changes, with the liquefaction degeneration of the basal cell layer, a moderate follicular hyperkeratosis, and a perivascular …
Subcutaneous panniculitis-like T-cell lymphoma, lupus erythematosus profundus, and overlapping cases: molecular characterization through the study of 208 genes.
Machan S, Rodríguez M, Alonso-Alonso R, Manso R, Pérez-Buira S, Borregón J, Rodríguez-Peralto JL, Cerroni L, Haro R, García C, García Toro E, Estrach T, García-Herrera A, Ferrer B, González-Cruz C, Segues N, Afonso-Martin JL, Peñate Y, Monteagudo C, Limeres-Gonzalez MÁ, González-Núñez MÁ, Torres MÁT, Cereceda L, Córdoba R, Piris MÁ, Requena L, María Rodríguez-Pinilla S. Machan S, et al. Leuk Lymphoma. 2021 Sep;62(9):2130-2140. doi: 10.1080/10428194.2021.1901098. Epub 2021 May 8. Leuk Lymphoma. 2021. PMID: 33966586
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic cutaneous lymphoma. Differential diagnosis with lupus erythematosus panniculitis (LEP) can be challenging and overlapping cases have been described. ...Most overlapping cases were clus …
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic cutaneous lymphoma. Differential diagnosis with lupus e
A double-blind pilot study of oral baricitinib in adult patients with lupus erythematosus panniculitis.
Chen J, Luo Y, Duan Y, Wang L, Long H, Liu Y, Yao X, Lu Q. Chen J, et al. J Dermatol. 2024 Nov;51(11):1434-1440. doi: 10.1111/1346-8138.17354. Epub 2024 Jul 19. J Dermatol. 2024. PMID: 39031307 Clinical Trial.
Lupus erythematosus panniculitis (LEP) is a chronic inflammatory skin disease with a significant impact on the overall well-being of patients. ...The primary endpoint was the proportion of patients with an RCLASI-A score decreased by 20% at week 12. Th
Lupus erythematosus panniculitis (LEP) is a chronic inflammatory skin disease with a significant impact on the overall
IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma.
Wong J, Roy SF, McNiff JM, Xu ML. Wong J, et al. Am J Surg Pathol. 2023 Dec 1;47(12):1425-1431. doi: 10.1097/PAS.0000000000002133. Epub 2023 Sep 28. Am J Surg Pathol. 2023. PMID: 37767989
Distinguishing lupus erythematosus panniculitis (LEP) from subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a diagnostic challenge with important clinical implications. ...Similarly, CD123-positive clusters in any location were observed in LEP …
Distinguishing lupus erythematosus panniculitis (LEP) from subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a …
Panniculitis: recent developments and observations.
White WL, Wieselthier JS, Hitchcock MG. White WL, et al. Semin Cutan Med Surg. 1996 Dec;15(4):278-99. doi: 10.1016/s1085-5629(96)80042-3. Semin Cutan Med Surg. 1996. PMID: 9069596 Review.
Eosinophils in lupus panniculitis and morphea profunda.
Peters MS, Su WP. Peters MS, et al. J Cutan Pathol. 1991 Jun;18(3):189-92. doi: 10.1111/j.1600-0560.1991.tb00151.x. J Cutan Pathol. 1991. PMID: 1918506
However, in most of the specimens, eosinophils were absent or observed in small numbers. Only 3% of patients with lupus panniculitis showed an increase in the number of eosinophils in the peripheral blood, whereas 47% of patients with morphea profunda had peripheral eosino …
However, in most of the specimens, eosinophils were absent or observed in small numbers. Only 3% of patients with lupus panniculitis …
Lupus erythematosus panniculitis in children and adolescents.
Guissa VR, Trudes G, Jesus AA, Aikawa NE, Romiti R, Silva CA. Guissa VR, et al. Acta Reumatol Port. 2012 Jan-Mar;37(1):82-5. Acta Reumatol Port. 2012. PMID: 22781517 Free article.
INTRODUCTION: Lupus erythematosus panniculitis (LEP) or lupus erythematosus profundus is a rare form of chronic cutaneous manifestation affecting both adults and pediatric patients. ...However, skin lesions improved only after rituximab treatment. DISCUSSION: …
INTRODUCTION: Lupus erythematosus panniculitis (LEP) or lupus erythematosus profundus is a rare form of chronic cutaneo …
Utility of CD123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T cell lymphoma.
Chen SJT, Tse JY, Harms PW, Hristov AC, Chan MP. Chen SJT, et al. Histopathology. 2019 May;74(6):908-916. doi: 10.1111/his.13817. Epub 2019 Mar 20. Histopathology. 2019. PMID: 30597607 Free article.
METHODS AND RESULTS: Skin biopsies of cutaneous lupus erythematosus (CLE, n = 18), lupus erythematosus panniculitis (LEP, n = 17), mycosis fungoides (MF, n = 25) and subcutaneous panniculitis-like T cell lymphoma (SPTCL, n = 9) were retrospectively reviewed a …
METHODS AND RESULTS: Skin biopsies of cutaneous lupus erythematosus (CLE, n = 18), lupus erythematosus panniculitis (LE …
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