Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma.
Kubo T, Sugawara T, Shinkawa T, Kurisu T, Kouzen N, Tanaka T, Fukuta F, Yamasaki K, Sugita S, Matsuo K, Morita R, Hirohashi Y, Tsukahara T, Kanaseki T, Hasegawa T, Masumori N, Torigoe T.
Kubo T, et al.
Immunol Med. 2021 Jun;44(2):136-141. doi: 10.1080/25785826.2020.1788229. Epub 2020 Jul 7.
Immunol Med. 2021.
PMID: 32634346
These lesions were infiltrated by large numbers of CD8-positive/TIA-1-positive lymphocytes. However, a metastatic lesion in the right kidney harbored few lymphocytes. Furthermore, the tumor cells in the metastatic lesion and one of the residual lesions showed decrea …
These lesions were infiltrated by large numbers of CD8-positive/TIA-1-positive lymphocytes. However, a metastatic lesion in the right …