Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2009 1
2010 2
2011 1
2012 1
2013 1
2015 1
2016 1
2017 2
2018 1
2019 1
2020 6
2021 12
2022 10
2023 3
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

33 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Lynch syndrome 5"
Page 1
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.
Seppälä TT, Latchford A, Negoi I, Sampaio Soares A, Jimenez-Rodriguez R, Sánchez-Guillén L, Evans DG, Ryan N, Crosbie EJ, Dominguez-Valentin M, Burn J, Kloor M, Knebel Doeberitz MV, Duijnhoven FJBV, Quirke P, Sampson JR, Møller P, Möslein G; European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP). Seppälä TT, et al. Br J Surg. 2021 May 27;108(5):484-498. doi: 10.1002/bjs.11902. Br J Surg. 2021. PMID: 34043773 Free PMC article.
BACKGROUND: Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. ...RESULTS: Recommendations for clinical and molecular identification of Lynch syndrome, surgical and endoscopic management of …
BACKGROUND: Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. …
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN. Soria F, et al. World J Urol. 2017 Mar;35(3):379-387. doi: 10.1007/s00345-016-1928-x. Epub 2016 Sep 7. World J Urol. 2017. PMID: 27604375 Free article. Review.
English language original articles, reviews and editorials were selected based on their clinical relevance. RESULTS: UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. ...It is further estimated that approximately 10 % of UTUC are part of the …
English language original articles, reviews and editorials were selected based on their clinical relevance. RESULTS: UTUC accounts for 5 …
Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.
Snowsill T, Coelho H, Huxley N, Jones-Hughes T, Briscoe S, Frayling IM, Hyde C. Snowsill T, et al. Health Technol Assess. 2017 Sep;21(51):1-238. doi: 10.3310/hta21510. Health Technol Assess. 2017. PMID: 28895526 Free PMC article. Review.
BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). ...OBJECTIVES: To investigate whether test …
BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal ca …
Universal Immunohistochemistry for Lynch Syndrome: A Systematic Review and Meta-analysis of 58,580 Colorectal Carcinomas.
Eikenboom EL, van der Werf-'t Lam AS, Rodríguez-Girondo M, Van Asperen CJ, Dinjens WNM, Hofstra RMW, Van Leerdam ME, Morreau H, Spaander MCW, Wagner A, Nielsen M. Eikenboom EL, et al. Clin Gastroenterol Hepatol. 2022 Mar;20(3):e496-e507. doi: 10.1016/j.cgh.2021.04.021. Epub 2021 Apr 19. Clin Gastroenterol Hepatol. 2022. PMID: 33887476 Free article.
BACKGROUND & AIMS: Lynch syndrome is a form of hereditary colorectal cancer (CRC) caused by pathogenic germline variants (PV) in DNA mismatch repair (MMR) genes. Currently, many Western countries perform universal immunohistochemistry testing on CR …
BACKGROUND & AIMS: Lynch syndrome is a form of hereditary colorectal cancer (CRC) caused by pathogenic germl …
Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE. Mitric C, et al. Gynecol Oncol. 2023 Mar;170:133-142. doi: 10.1016/j.ygyno.2022.12.008. Epub 2023 Jan 20. Gynecol Oncol. 2023. PMID: 36682091 Review.
OBJECTIVE: Investigating for mismatch repair protein deficiency (MMRd), microsatellite instability (MSI), and Lynch syndrome (LS) is widely accepted in endometrial cancer, but knowledge is limited on its value in epithelial ovarian cancer (EOC). The primary objectiv …
OBJECTIVE: Investigating for mismatch repair protein deficiency (MMRd), microsatellite instability (MSI), and Lynch syndrome ( …
Worldwide prevalence of Lynch syndrome in patients with colorectal cancer: Systematic review and meta-analysis.
Abu-Ghazaleh N, Kaushik V, Gorelik A, Jenkins M, Macrae F. Abu-Ghazaleh N, et al. Genet Med. 2022 May;24(5):971-985. doi: 10.1016/j.gim.2022.01.014. Epub 2022 Feb 15. Genet Med. 2022. PMID: 35177335 Free article. Review.
PURPOSE: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, with an estimated prevalence of 2% to 3% of CRC. ...Studies performing germline tests on all participants with CRC reported higher prevalence (5. …
PURPOSE: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, with an esti …
A scoping review and meta-analysis on the prevalence of pan-tumour biomarkers (dMMR, MSI, high TMB) in different solid tumours.
Kang YJ, O'Haire S, Franchini F, IJzerman M, Zalcberg J, Macrae F, Canfell K, Steinberg J. Kang YJ, et al. Sci Rep. 2022 Nov 28;12(1):20495. doi: 10.1038/s41598-022-23319-1. Sci Rep. 2022. PMID: 36443366 Free PMC article.
The prevalence profiles of dMMR/MSI and high TMB differed across cancer types. For example, endometrial, colorectal, small bowel and gastric cancers showed high prevalence of both dMMR and MSI (range: 8.7-26.8% and 8.5-21.9%, respectively) and high TMB (range: 8. …
The prevalence profiles of dMMR/MSI and high TMB differed across cancer types. For example, endometrial, colorectal, small bowel and …
Systematic review and meta-analysis of tumour microsatellite-instability status as a predictor of response to fluorouracil-based adjuvant chemotherapy in colorectal cancer.
Aggarwal N, Quaglia A, McPhail MJW, Monahan KJ. Aggarwal N, et al. Int J Colorectal Dis. 2022 Jan;37(1):35-46. doi: 10.1007/s00384-021-04046-x. Epub 2021 Oct 22. Int J Colorectal Dis. 2022. PMID: 34677685 Free PMC article. Review.
Adjuvant therapy after surgery in advanced CRC is usually based on fluoropyrimidine 5-fluorouracil (5-FU) alone or combined with other agents. Controversy however remains on the use of 5-FU-based regimens in treating MSI-related tumours. AIMS: To systematical …
Adjuvant therapy after surgery in advanced CRC is usually based on fluoropyrimidine 5-fluorouracil (5-FU) alone or combined wi …
Unexplained mismatch repair deficiency: Case closed.
Eikenboom EL, Moen S, van Leeuwen L, Geurts-Giele WRR, Tops CMJ, van Ham TJ, Dinjens WNM, Dubbink HJ, Spaander MCW, Wagner A. Eikenboom EL, et al. HGG Adv. 2022 Dec 14;4(1):100167. doi: 10.1016/j.xhgg.2022.100167. eCollection 2023 Jan 12. HGG Adv. 2022. PMID: 36624813 Free PMC article.
To identify Lynch syndrome (LS) carriers, DNA mismatch repair (MMR) immunohistochemistry (IHC) is performed on colorectal cancers (CRCs). ...Of those, nine were suspected to have LS. In our center, complete LS diagnostics in approximately 5,000 CRCs le …
To identify Lynch syndrome (LS) carriers, DNA mismatch repair (MMR) immunohistochemistry (IHC) is performed on colorectal …
Screening and risk reducing surgery for endometrial or ovarian cancers in Lynch syndrome: a systematic review.
Lim N, Hickey M, Young GP, Macrae FA, Kelly C. Lim N, et al. Int J Gynecol Cancer. 2022 May 3;32(5):646-655. doi: 10.1136/ijgc-2021-003132. Int J Gynecol Cancer. 2022. PMID: 35437274 Free PMC article.
OBJECTIVE: Lynch syndrome is a hereditary cancer syndrome caused by mismatch repair gene mutations, and female carriers are at an increased risk of endometrial and ovarian cancer. ...Risk reducing surgery remains the most reliable way to reduce endomet …
OBJECTIVE: Lynch syndrome is a hereditary cancer syndrome caused by mismatch repair gene mutations, and female c …
33 results