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Quoted phrase not found in phrase index: "Lynch syndrome 8"
Page 1
ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach.
Luchini C, Bibeau F, Ligtenberg MJL, Singh N, Nottegar A, Bosse T, Miller R, Riaz N, Douillard JY, Andre F, Scarpa A. Luchini C, et al. Ann Oncol. 2019 Aug 1;30(8):1232-1243. doi: 10.1093/annonc/mdz116. Ann Oncol. 2019. PMID: 31056702 Free article.
Next-generation sequencing, coupling MSI and TMB analysis, may represent a decisive tool for selecting patients for immunotherapy, for common or rare cancers not belonging to the spectrum of Lynch syndrome (very strong agreement). The relationships between MSI, TMB …
Next-generation sequencing, coupling MSI and TMB analysis, may represent a decisive tool for selecting patients for immunotherapy, for commo …
Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE. Mitric C, et al. Gynecol Oncol. 2023 Mar;170:133-142. doi: 10.1016/j.ygyno.2022.12.008. Epub 2023 Jan 20. Gynecol Oncol. 2023. PMID: 36682091 Review.
OBJECTIVE: Investigating for mismatch repair protein deficiency (MMRd), microsatellite instability (MSI), and Lynch syndrome (LS) is widely accepted in endometrial cancer, but knowledge is limited on its value in epithelial ovarian cancer (EOC). The primary objectiv …
OBJECTIVE: Investigating for mismatch repair protein deficiency (MMRd), microsatellite instability (MSI), and Lynch syndrome ( …
Ovarian cancer in Lynch syndrome; a systematic review.
Helder-Woolderink JM, Blok EA, Vasen HF, Hollema H, Mourits MJ, De Bock GH. Helder-Woolderink JM, et al. Eur J Cancer. 2016 Mar;55:65-73. doi: 10.1016/j.ejca.2015.12.005. Epub 2016 Jan 13. Eur J Cancer. 2016. PMID: 26773421 Review.
OBJECTIVE: The aim was to systematically review the characteristics of ovarian cancer in women with Lynch syndrome (LS) and evaluate the role of surveillance in detection of ovarian cancer in LS. ...RESULTS: The quality score of the 49 identified studies was at leas …
OBJECTIVE: The aim was to systematically review the characteristics of ovarian cancer in women with Lynch syndrome (LS) and ev …
Risk of breast cancer in Lynch syndrome: a systematic review.
Win AK, Lindor NM, Jenkins MA. Win AK, et al. Breast Cancer Res. 2013 Mar 19;15(2):R27. doi: 10.1186/bcr3405. Breast Cancer Res. 2013. PMID: 23510156 Free PMC article. Review.
INTRODUCTION: Lynch syndrome is an autosomal dominantly inherited disorder of cancer susceptibility caused by germline mutations in the DNA mismatch repair (MMR) genes. ...Of the 21 risk studies identified, 13 did not observe statistical evidence for an association …
INTRODUCTION: Lynch syndrome is an autosomal dominantly inherited disorder of cancer susceptibility caused by germline mutatio …
Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis.
Power RF, Doherty DE, Parker I, Gallagher DJ, Lowery MA, Cadoo KA. Power RF, et al. JCO Precis Oncol. 2024 Jan;8:e2300196. doi: 10.1200/PO.23.00196. JCO Precis Oncol. 2024. PMID: 38207227
PURPOSE: Lynch syndrome is the most common hereditary cause of colorectal and endometrial cancers. Modifiable risk factors, including obesity, physical activity, alcohol intake, and smoking, are well-established in sporadic cancers but are less studied …
PURPOSE: Lynch syndrome is the most common hereditary cause of colorectal and endometrial cancers. Modifiable ri …
The prevalence and incidence of progressive supranuclear palsy and corticobasal syndrome: a systematic review and meta-analysis.
Lyons S, Trépel D, Lynch T, Walsh R, O'Dowd S. Lyons S, et al. J Neurol. 2023 Sep;270(9):4451-4465. doi: 10.1007/s00415-023-11791-2. Epub 2023 Jun 8. J Neurol. 2023. PMID: 37289323 Free PMC article.
INTRODUCTION: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are progressive neurodegenerative syndromes characterised by Parkinsonism with additional features including cognitive dysfunction, falls, and oculomotor abnormalities. ...Reported estimates …
INTRODUCTION: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are progressive neurodegenerative syndromes charac …
Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.
Snowsill T, Coelho H, Huxley N, Jones-Hughes T, Briscoe S, Frayling IM, Hyde C. Snowsill T, et al. Health Technol Assess. 2017 Sep;21(51):1-238. doi: 10.3310/hta21510. Health Technol Assess. 2017. PMID: 28895526 Free PMC article. Review.
BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). ...OBJECTIVES: To investigate whether test …
BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal ca …
Risk of metachronous colorectal cancer following colectomy in Lynch syndrome: a systematic review and meta-analysis.
Anele CC, Adegbola SO, Askari A, Rajendran A, Clark SK, Latchford A, Faiz OD. Anele CC, et al. Colorectal Dis. 2017 Jun;19(6):528-536. doi: 10.1111/codi.13679. Colorectal Dis. 2017. PMID: 28407411 Free article. Review.
AIM: Lynch syndrome (LS) accounts for 2-4% of all colorectal cancer (CRC) cases, and is associated with an increased risk of developing metachronous colorectal cancer (mCRC). ...Of these, 705 (80.9%) underwent segmental colectomy and 166 (19.1%) extend …
AIM: Lynch syndrome (LS) accounts for 2-4% of all colorectal cancer (CRC) cases, and is associated with an increased ri …
A scoping review and meta-analysis on the prevalence of pan-tumour biomarkers (dMMR, MSI, high TMB) in different solid tumours.
Kang YJ, O'Haire S, Franchini F, IJzerman M, Zalcberg J, Macrae F, Canfell K, Steinberg J. Kang YJ, et al. Sci Rep. 2022 Nov 28;12(1):20495. doi: 10.1038/s41598-022-23319-1. Sci Rep. 2022. PMID: 36443366 Free PMC article.
The prevalence profiles of dMMR/MSI and high TMB differed across cancer types. For example, endometrial, colorectal, small bowel and gastric cancers showed high prevalence of both dMMR and MSI (range: 8.7-26.8% and 8.5-21.9%, respectively) and high TMB …
The prevalence profiles of dMMR/MSI and high TMB differed across cancer types. For example, endometrial, colorectal, small bowel and …
Immunohistochemical Screening of Upper Tract Urothelial Carcinomas for Lynch Syndrome Diagnostics: A Systematic Review.
Rasmussen M, Madsen MG, Therkildsen C. Rasmussen M, et al. Urology. 2022 Jul;165:44-53. doi: 10.1016/j.urology.2022.02.006. Epub 2022 Feb 22. Urology. 2022. PMID: 35217028 Free article. Review.
In 11 studies, 140 of the 1559 patients had tumors with loss (9.0%) with 80.7% showing loss of MSH2, MSH6, or both. In 7 studies, genetic testing confirmed Lynch syndrome diagnosis for 20 of 970 patients (2.1%). In 8 studies, 31 patients were given a clinical …
In 11 studies, 140 of the 1559 patients had tumors with loss (9.0%) with 80.7% showing loss of MSH2, MSH6, or both. In 7 studies, genetic te …
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