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Treatment considerations for MGMT-unmethylated glioblastoma.
Taylor JW, Schiff D. Taylor JW, et al. Curr Neurol Neurosci Rep. 2015 Jan;15(1):507. doi: 10.1007/s11910-014-0507-z. Curr Neurol Neurosci Rep. 2015. PMID: 25394859 Review.
This article reviews the data establishing MGMT promoter methylation as a prognostic factor in glioblastoma and its potential role as a predictor of temozolomide response. It focuses on results from recent studies in newly diagnosed glioblastoma, and the role of temozolomi …
This article reviews the data establishing MGMT promoter methylation as a prognostic factor in glioblastoma and its potential role as a p …
Tumor-associated alterations in white matter connectivity have prognostic significance in MGMT-unmethylated glioblastoma.
Rammohan N, Ho A, Saxena M, Bajaj A, Kruser TJ, Horbinski C, Korutz A, Tate M, Sachdev S. Rammohan N, et al. J Neurooncol. 2022 Jul;158(3):331-339. doi: 10.1007/s11060-022-04018-3. Epub 2022 May 7. J Neurooncol. 2022. PMID: 35525907
For each patient, 22 TA-WM tracts were analyzed and each tract was graded 1-3 based on FA. A TA-WM score (TA-WMS) was computed based on number of involved tracts and corresponding FA grade of involvement. ...For MGMT-unmethylated patients, TA-WMS was predictive of o …
For each patient, 22 TA-WM tracts were analyzed and each tract was graded 1-3 based on FA. A TA-WM score (TA-WMS) was computed based …
Subventricular zone contacting glioblastoma: tumor size, molecular biological factors and patient survival.
Hallaert G, Pinson H, Van den Broecke C, Vanhauwaert D, Van Roost D, Boterberg T, Kalala JP. Hallaert G, et al. Acta Oncol. 2020 Dec;59(12):1474-1479. doi: 10.1080/0284186X.2020.1794032. Epub 2020 Jul 16. Acta Oncol. 2020. PMID: 32672481

Median tumor volume was significantly larger in the SVZ(pos) group (33,8 mL vs 15,6 mL; p < .001). MGMT-unmethylated glioblastoma was more frequent in the SVZ(pos) group (61.4% vs 44.9%; p = .028). ...SVZ(pos) glioblastoma had larger tumor size and a large

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Median tumor volume was significantly larger in the SVZ(pos) group (33,8 mL vs 15,6 mL; p < .001). MGMT-unmethylated gli

…
Prognostic impact of obesity in newly-diagnosed glioblastoma: a secondary analysis of CeTeG/NOA-09 and GLARIUS.
Weller J, Schäfer N, Schaub C, Potthoff AL, Steinbach JP, Schlegel U, Sabel M, Hau P, Seidel C, Krex D, Goldbrunner R, Pietsch T, Tzaridis T, Zeyen T, Borger V, Güresir E, Vatter H, Herrlinger U, Schneider M. Weller J, et al. J Neurooncol. 2022 Aug;159(1):95-101. doi: 10.1007/s11060-022-04046-z. Epub 2022 Jun 15. J Neurooncol. 2022. PMID: 35704157 Free PMC article. Clinical Trial.
Obesity was associated with shorter survival in patients with MGMT methylated glioblastoma (median OS 22.9 (95% CI 17.7-30.8) vs. 43.2 (32.5-54.4) months for obese and non-obese patients respectively, p = 0.001), but not in MGMT unmethylated glioblastoma (med …
Obesity was associated with shorter survival in patients with MGMT methylated glioblastoma (median OS 22.9 (95% CI 17.7-30.8) vs. 43.2 (32.5 …
Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients.
Chen YY, Ho HL, Lin SC, Ho TD, Hsu CY. Chen YY, et al. Am J Clin Pathol. 2018 Mar 29;149(5):412-417. doi: 10.1093/ajcp/aqy008. Am J Clin Pathol. 2018. PMID: 29538610
RESULTS: Upregulation of miR 125b-5p, miR 181d-3p, miR 221-3p, miR-222-3p, and miR 224-5p was observed in 13.2%, 5.3%, 12.3%, 32.5%, and 78.9% of the cases, respectively. ...Upregulation of miR 125b-5p, miR 181d-3p, or miR 221-3p was significantly associated with shorter s …
RESULTS: Upregulation of miR 125b-5p, miR 181d-3p, miR 221-3p, miR-222-3p, and miR 224-5p was observed in 13.2%, 5.3%, 12.3%, 32.5%, …