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Quoted phrase not found in phrase index: "MTOR Gene Rearrangement"
Page 1
Perivascular epithelioid cell tumors (PEComa) of the gynecologic tract.
Bennett JA, Oliva E. Bennett JA, et al. Genes Chromosomes Cancer. 2021 Mar;60(3):168-179. doi: 10.1002/gcc.22908. Epub 2020 Nov 6. Genes Chromosomes Cancer. 2021. PMID: 33099813 Review.
Recognition of the first group is imperative as these patients may benefit from targeted therapy with mTOR inhibitors, if malignant. This review will focus on recognition of the morphologic and immunophenotypic features of PEComas, as well as the role of molecular testing …
Recognition of the first group is imperative as these patients may benefit from targeted therapy with mTOR inhibitors, if malignant. …
Characterization of genomic alterations and the significance of PI3K/mTOR pathway mutations and tumor mutational burden in non-small cell lung cancer.
Hu J, Shang Y, Shi X, Zhang S, Shi J, Yao M, Wang A, Shou T, Shi W, Wang K, Liu A, Pan X, Wang Y. Hu J, et al. Oncol Rep. 2020 Jun;43(6):2053-2061. doi: 10.3892/or.2020.7559. Epub 2020 Mar 23. Oncol Rep. 2020. PMID: 32236597
Tumor mutational burden was calculated and results revealed that it was associated with PI3K/mTOR pathway gene mutations, and patient's gender, age, smoking status, and tumor stage. ...The current data showed that NSCLC with PI3K/mTOR mutations are sensitive …
Tumor mutational burden was calculated and results revealed that it was associated with PI3K/mTOR pathway gene mutations, and …
Multiple gene aberrations and breast cancer: lessons from super-responders.
Wheler JJ, Atkins JT, Janku F, Moulder SL, Yelensky R, Stephens PJ, Kurzrock R. Wheler JJ, et al. BMC Cancer. 2015 May 29;15:442. doi: 10.1186/s12885-015-1439-y. BMC Cancer. 2015. PMID: 26021831 Free PMC article.
Primary breast tissue was available for NGS testing in three of the responders (partial response with progression free survival of 11 and 14 months, respectively; complete response with progression free survival of 9+ months). The following molecular aberrations were observed …
Primary breast tissue was available for NGS testing in three of the responders (partial response with progression free survival of 11 and 14 …
Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.
Sandhöfer N, Metzeler KH, Rothenberg M, Herold T, Tiedt S, Groiß V, Carlet M, Walter G, Hinrichsen T, Wachter O, Grunert M, Schneider S, Subklewe M, Dufour A, Fröhling S, Klein HG, Hiddemann W, Jeremias I, Spiekermann K. Sandhöfer N, et al. Leukemia. 2015 Apr;29(4):828-38. doi: 10.1038/leu.2014.305. Epub 2014 Oct 17. Leukemia. 2015. PMID: 25322685
By analyzing primary samples and cell lines, we observed a wide range of cytotoxic activity for inhibition of AKT (MK-2206), mTORC1 (rapamycin) and PI3K/mTORC1/2 (BEZ-235) with a high sensitivity of cells carrying an MLL rearrangement. ...Further in vitro studies co …
By analyzing primary samples and cell lines, we observed a wide range of cytotoxic activity for inhibition of AKT (MK-2206), mTORC1 ( …
Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.
Tasian SK, Doral MY, Borowitz MJ, Wood BL, Chen IM, Harvey RC, Gastier-Foster JM, Willman CL, Hunger SP, Mullighan CG, Loh ML. Tasian SK, et al. Blood. 2012 Jul 26;120(4):833-42. doi: 10.1182/blood-2011-12-389932. Epub 2012 Jun 8. Blood. 2012. PMID: 22685175 Free PMC article.
TSLP stimulation of these leukemias further induced robust JAK/STAT and PI3K/mTOR pathway signaling. JAK inhibition abrogated phosphorylation of JAK/STAT and, surprisingly, of PI3K/mTOR pathway members, suggesting an interconnection between these signaling networks …
TSLP stimulation of these leukemias further induced robust JAK/STAT and PI3K/mTOR pathway signaling. JAK inhibition abrogated phospho …
Clinicopathological and genomic characterization of BCORL1-driven high-grade endometrial stromal sarcomas.
Lin DI, Huang RSP, Mata DA, Decker B, Danziger N, Lechpammer M, Hiemenz M, Ramkissoon SH, Ross JS, Elvin JA. Lin DI, et al. Mod Pathol. 2021 Dec;34(12):2200-2210. doi: 10.1038/s41379-021-00873-z. Epub 2021 Jul 23. Mod Pathol. 2021. PMID: 34302054 Free article.
We describe 12 BCORL1-altered uterine sarcomas with striking resemblance to BCOR-altered endometrial stromal sarcoma (BCOR-ESS), including 5 with BCORL1 rearrangements (JAZF1-BCORL1, EP300-BCORL1, or internal BCORL1 rearrangement), 5 with inactivating BCORL1 mutations (T51 …
We describe 12 BCORL1-altered uterine sarcomas with striking resemblance to BCOR-altered endometrial stromal sarcoma (BCOR-ESS), including 5 …
Comprehensive genomic sequencing and the molecular profiles of clinically advanced breast cancer.
Ross JS, Gay LM. Ross JS, et al. Pathology. 2017 Feb;49(2):120-132. doi: 10.1016/j.pathol.2016.11.005. Epub 2016 Dec 26. Pathology. 2017. PMID: 28034454
Next-generation sequencing (NGS) technologies can also test for these well-known hot spots, as well as identifying insertions and deletions, copy number changes such as ERBB2 (HER2) gene amplification, and a wide array of fusion or rearrangement events. ...Comprehen …
Next-generation sequencing (NGS) technologies can also test for these well-known hot spots, as well as identifying insertions and deletions, …
Stimulator of interferon genes (STING) immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney.
Caliò A, Brunelli M, Gobbo S, Pedron S, Segala D, Argani P, Martignoni G. Caliò A, et al. Pathology. 2021 Aug;53(5):579-585. doi: 10.1016/j.pathol.2020.09.025. Epub 2021 Jan 16. Pathology. 2021. PMID: 33461798
Angiomyolipoma is the prototype of renal perivascular epithelioid cell (PEC) lesions whose pathogenesis is determined by mutations affecting TSC genes, with eventual deregulation of the mTOR pathway. It is well known that mTOR complex protein is involved in autophag …
Angiomyolipoma is the prototype of renal perivascular epithelioid cell (PEC) lesions whose pathogenesis is determined by mutations affecting …
Invasive apocrine carcinoma of the breast: clinicopathologic features and comprehensive genomic profiling of 18 pure triple-negative apocrine carcinomas.
Sun X, Zuo K, Yao Q, Zhou S, Shui R, Xu X, Bi R, Yu B, Cheng Y, Tu X, Lu H, Yang W. Sun X, et al. Mod Pathol. 2020 Dec;33(12):2473-2482. doi: 10.1038/s41379-020-0589-x. Epub 2020 Jun 5. Mod Pathol. 2020. PMID: 32504034 Free article.
There were four novel mutations found in PTEN and an actionable rearrangement involving FGFR2-TACC2 that has not been reported in breast cancer before. In total, 88.9%, 50%, 44.4%, and 16.7% of TNACs had at least one clinically relevant genomic alteration in genes involved …
There were four novel mutations found in PTEN and an actionable rearrangement involving FGFR2-TACC2 that has not been reported in bre …
Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics.
Schoolmeester JK, Carlson J, Keeney GL, Fritchie KJ, Oliva E, Young RH, Nucci MR. Schoolmeester JK, et al. Am J Surg Pathol. 2017 May;41(5):622-632. doi: 10.1097/PAS.0000000000000796. Am J Surg Pathol. 2017. PMID: 28009610
Alveolar soft part sarcoma (ASPS) is a morphologically distinctive neoplasm of unknown differentiation that bears a characteristic gene fusion involving ASPSCR1 and TFE3. ASPS can occur in the female genital tract, but is rare. ...Distinguishing ASPS from its morphologic m …
Alveolar soft part sarcoma (ASPS) is a morphologically distinctive neoplasm of unknown differentiation that bears a characteristic gene …
15 results