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Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome.
Huang WC, Chen Y, Page DT. Huang WC, et al. Nat Commun. 2016 Nov 15;7:13421. doi: 10.1038/ncomms13421. Nat Commun. 2016. PMID: 27845329 Free PMC article.
We show that mTOR signalling is dysregulated during early postnatal development in the cerebral cortex of germ-line heterozygous Pten mutant mice (Pten(+/-)), which model macrocephaly/autism syndrome. The basolateral amygdala (BLA) receives input from subcort …
We show that mTOR signalling is dysregulated during early postnatal development in the cerebral cortex of germ-line heterozygous Pten mutant …