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Clonal Megakaryocyte Dysplasia with Normal Blood Values Is a Distinct Myeloproliferative Neoplasm.
Barosi G, Rosti V, Massa M, Campanelli R, Villani L, Catarsi P, Carolei A, Abbà C, Lodigiani C, Primignani M, Gregato G, Bertolini F, Magrini U, Gale RP. Barosi G, et al. Acta Haematol. 2022;145(1):30-37. doi: 10.1159/000517207. Epub 2021 Jul 19. Acta Haematol. 2022. PMID: 34280924 Clinical Trial.
CONCLUSION: Our data indicate that these 15 persons have a distinct myeloproliferative neoplasm. We propose naming this new disorder clonal megakaryocyte dysplasia with normal blood values....
CONCLUSION: Our data indicate that these 15 persons have a distinct myeloproliferative neoplasm. We propose naming this new disorder clonal …
Clinical and Pathologic Spectrum of DDX41-Mutated Hematolymphoid Neoplasms.
Goyal T, Tu ZJ, Wang Z, Cook JR. Goyal T, et al. Am J Clin Pathol. 2021 Oct 13;156(5):829-838. doi: 10.1093/ajcp/aqab027. Am J Clin Pathol. 2021. PMID: 33929502
DDX41-mutated neoplasms were morphologically heterogeneous with a median cellularity of 20% (range, 10%-100%). Megakaryocyte dysplasia occurred in 7 (35%) of 20 cases and trilineage dysplasia in 1 (5%). ...
DDX41-mutated neoplasms were morphologically heterogeneous with a median cellularity of 20% (range, 10%-100%). Megakaryocyte dyspl …
Quality control initiative on the evaluation of the dysmegakaryopoiesis in myeloid neoplasms: Difficulties in the assessment of dysplasia.
Goasguen JE, Bennett JM, Bain BJ, Brunning RD, Vallespí MT, Tomonaga M, Zini G, Renault A; International Working Group on Morphology of MDS IWGM-MDS. Goasguen JE, et al. Leuk Res. 2016 Jun;45:75-81. doi: 10.1016/j.leukres.2016.04.009. Epub 2016 Apr 11. Leuk Res. 2016. PMID: 27107657 Free article.
Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MDS; although evaluation of 30 megakaryocytes is strongly recommended, it may be possible to recognize diagnostically important dysplasia when …
Our results demonstrate that the nature as well as the presence of megakaryocyte dysplasia is important in the diagnosis of MD …
Transitory response of a myelodysplastic syndrome with deletion of chromosome 5q to thalidomide. Report of one case.
Palacios-Campos A, Gutierrez O, Fabian-Morales E, Avilés A, Candelaria M. Palacios-Campos A, et al. Rev Med Chil. 2020 Sep;148(9):1357-1361. doi: 10.4067/S0034-98872020000901357. Rev Med Chil. 2020. PMID: 33399713 Free article.
Afterwards, she developed pancytopenia and a bone marrow biopsy showed erythroid and megakaryocyte dysplasia with a complex karyotype, which worsened prognosis (IPSS-R of five points). ...
Afterwards, she developed pancytopenia and a bone marrow biopsy showed erythroid and megakaryocyte dysplasia with a complex ka …