Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma.
Gu F, Chen TH, Pfeiffer RM, Fargnoli MC, Calista D, Ghiorzo P, Peris K, Puig S, Menin C, De Nicolo A, Rodolfo M, Pellegrini C, Pastorino L, Evangelou E, Zhang T, Hua X, DellaValle CT, Timothy Bishop D, MacGregor S, Iles MI, Law MH, Cust A, Brown KM, Stratigos AJ, Nagore E, Chanock S, Shi J, Consortium MM, Consortium M, Landi MT.
Gu F, et al.
Hum Mol Genet. 2018 Dec 1;27(23):4145-4156. doi: 10.1093/hmg/ddy282.
Hum Mol Genet. 2018.
PMID: 30060076
Free PMC article.
To date, only SNPs that reached statistical significance in genome-wide association studies or few candidate SNPs have been included in melanoma risk prediction models. We compared four approaches for building polygenic risk scores (PRS) using 12 874 melan …
To date, only SNPs that reached statistical significance in genome-wide association studies or few candidate SNPs have been included in m …