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Page 1
Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans.
Isenmann E, Ambrosio G, Joseph JF, Mazzarino M, de la Torre X, Zimmer P, Kazlauskas R, Goebel C, Botrè F, Diel P, Parr MK. Isenmann E, et al. Arch Toxicol. 2019 Jul;93(7):1807-1816. doi: 10.1007/s00204-019-02490-x. Epub 2019 May 23. Arch Toxicol. 2019. PMID: 31123801 Clinical Trial.
In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. ...
In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in …
Detectability of oxandrolone, metandienone, clostebol and dehydrochloromethyltestosterone in urine after transdermal application.
Gessner L, Thevis M, Rothschild MA, Jübner M. Gessner L, et al. Drug Test Anal. 2022 Oct;14(10):1744-1761. doi: 10.1002/dta.3355. Epub 2022 Sep 2. Drug Test Anal. 2022. PMID: 35947101
One half of the test persons received only oxandrolone (17alpha-methyl-2-oxa-4,5alpha-dihydrotestosterone), and the other half were applied a mixture of oxandrolone, metandienone (17beta-hydroxy-17alpha-methylandrosta-1,4-dien-3-one), clostebol (4-chlorotestosterone-17beta …
One half of the test persons received only oxandrolone (17alpha-methyl-2-oxa-4,5alpha-dihydrotestosterone), and the other half were applied …
HepG2 as promising cell-based model for biosynthesis of long-term metabolites: Exemplified for metandienone.
Zschiesche A, Chundela Z, Thieme D, Keiler AM. Zschiesche A, et al. Drug Test Anal. 2022 Feb;14(2):298-306. doi: 10.1002/dta.3184. Epub 2021 Nov 1. Drug Test Anal. 2022. PMID: 34705329
The metandienone metabolites formed by HepG2 cells were comparable with those renally excreted by humans. ...In conclusion, we showed that HepG2 cells are suitable as model for the investigation of biotransformation of androgens, especially for the anabolic androgenic ster …
The metandienone metabolites formed by HepG2 cells were comparable with those renally excreted by humans. ...In conclusion, we showed …
New Insights into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel A-Ring Reduced Metabolites.
Loke S, Liu L, Wenzel M, Scheffler H, Iannone M, de la Torre X, Schlörer N, Botrè F, Keiler AM, Bureik M, Parr MK. Loke S, et al. Molecules. 2021 Mar 3;26(5):1354. doi: 10.3390/molecules26051354. Molecules. 2021. PMID: 33802606 Free PMC article.
Metandienone and methyltestosterone are orally active anabolic-androgenic steroids with a 17alpha-methyl structure that are prohibited in sports but are frequently detected in anti-doping analysis. Following the previously reported detection of long-term metabolites with a
Metandienone and methyltestosterone are orally active anabolic-androgenic steroids with a 17alpha-methyl structure that are prohibite
Metabolism of metandienone in man: identification and synthesis of conjugated excreted urinary metabolites, determination of excretion rates and gas chromatographic-mass spectrometric identification of bis-hydroxylated metabolites.
Schänzer W, Geyer H, Donike M. Schänzer W, et al. J Steroid Biochem Mol Biol. 1991 Apr;38(4):441-64. doi: 10.1016/0960-0760(91)90332-y. J Steroid Biochem Mol Biol. 1991. PMID: 2031859
After oral administration of metandienone (17 alpha-methyl-androsta-1,4-dien-17 beta-ol-3-one) to male volunteers conjugated metabolites are isolated from urine via XAD-2-adsorption, enzymatic hydrolysis and preparative high-performance liquid chromatography (HPLC). Four c …
After oral administration of metandienone (17 alpha-methyl-androsta-1,4-dien-17 beta-ol-3-one) to male volunteers conjugated metaboli …
Synthesis of 17beta-hydroxymethyl-17alpha-methyl-18-norandrosta-1,4,13-trien-3-one: A long-term metandienone metabolite.
Kratena N, Enev VS, Gmeiner G, Gärtner P. Kratena N, et al. Steroids. 2016 Nov;115:75-79. doi: 10.1016/j.steroids.2016.08.013. Epub 2016 Aug 21. Steroids. 2016. PMID: 27553728
The goal of this work was a good-yielding chemical synthesis of a metandienone metabolite which is of interest in doping analysis. 20betaOH-NorMD (IUPAC: 17beta-hydroxymethyl-17alpha-methyl-18-norandrosta-1,4,13-triene-3-one) has been identified as a long-term urinary meta …
The goal of this work was a good-yielding chemical synthesis of a metandienone metabolite which is of interest in doping analysis. 20 …
Doping control for metandienone using hair analyzed by gas chromatography-tandem mass spectrometry.
Bresson M, Cirimele V, Villain M, Kintz P. Bresson M, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):124-8. doi: 10.1016/j.jchromb.2006.03.040. Epub 2006 Apr 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2006. PMID: 16597518
A sensitive, specific and reproducible method for the quantitative determination of the anabolic metandienone in human hair has been developed. The preparation involved a decontamination step with methylene chloride. ...Linearity was observed for metandienone concen …
A sensitive, specific and reproducible method for the quantitative determination of the anabolic metandienone in human hair has been …
LC-MS/MS detection of unaltered glucuronoconjugated metabolites of metandienone.
Esquivel A, Pozo OJ, Garrostas L, Balcells G, Gómez C, Kotronoulas A, Joglar J, Ventura R. Esquivel A, et al. Drug Test Anal. 2017 Apr;9(4):534-544. doi: 10.1002/dta.1996. Epub 2016 May 30. Drug Test Anal. 2017. PMID: 27237125
The aim of this study was to evaluate the direct detection of glucuronoconjugated metabolites of metandienone (MTD) and their detection times. Metabolites resistant to enzymatic hydrolysis were also evaluated. ...
The aim of this study was to evaluate the direct detection of glucuronoconjugated metabolites of metandienone (MTD) and their detecti …
Anabolic steroids and extreme violence: a case of murder after chronic intake and under acute influence of metandienone and trenbolone.
Aknouche F, Gheddar L, Kernalléguen A, Maruejouls C, Kintz P. Aknouche F, et al. Int J Legal Med. 2021 Jul;135(4):1449-1453. doi: 10.1007/s00414-021-02587-y. Epub 2021 Apr 4. Int J Legal Med. 2021. PMID: 33813613
The blood was free of alcohol, pharmaceuticals and drugs of abuse, but tested positive by LC-MS/MS for metandienone (32 ng/mL) and trenbolone (9 ng/mL). The perpetrator admitted regular consumption of anabolic steroids to enhance his muscular mass, as he was a professional …
The blood was free of alcohol, pharmaceuticals and drugs of abuse, but tested positive by LC-MS/MS for metandienone (32 ng/mL) and tr …
A new sulphate metabolite as a long-term marker of metandienone misuse.
Gómez C, Pozo OJ, Garrostas L, Segura J, Ventura R. Gómez C, et al. Steroids. 2013 Dec 11;78(12-13):1245-53. doi: 10.1016/j.steroids.2013.09.005. Epub 2013 Sep 19. Steroids. 2013. PMID: 24055830
Metandienone is one of the most frequently detected anabolic androgenic steroids in sports drug testing. ...Therefore, sulphation is an important phase II metabolic pathway of metandienone that has not been comprehensively studied. The aim of this work was to evalua
Metandienone is one of the most frequently detected anabolic androgenic steroids in sports drug testing. ...Therefore, sulphation is
59 results