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Year Number of Results
1993 1
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11 results

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Page 1
Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM. Kesari S, et al. Sci Rep. 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. Sci Rep. 2023. PMID: 37147496 Free PMC article.
Pemetrexed inhibited growth in a preclinical mouse xenograft model of human chordoma. We report three cases of metastatic chordoma that had been heavily treated previously with a variety of standard therapies with poor response. ...
Pemetrexed inhibited growth in a preclinical mouse xenograft model of human chordoma. We report three cases of metastatic chordoma …
Imaging characteristics of metastatic chordoma.
Kishimoto R, Omatsu T, Hasegawa A, Imai R, Kandatsu S, Kamada T. Kishimoto R, et al. Jpn J Radiol. 2012 Jul;30(6):509-16. doi: 10.1007/s11604-012-0086-3. Epub 2012 May 18. Jpn J Radiol. 2012. PMID: 22592289
Osteolytic lesions were most common bone metastases, but osteosclerotic metastasis was also encountered. Metastatic chordoma showed very high intensity on diffusion-weighted (DW) images in 29 of 31 patients. ...The high intensity of DW images is characteristic and h …
Osteolytic lesions were most common bone metastases, but osteosclerotic metastasis was also encountered. Metastatic chordoma s …
Effect of hyperthermia and proton beam radiation as a novel approach in chordoma cells death and its clinical implication to treat chordoma.
Singh P, Eley J, Saeed A, Bhandary B, Mahmood N, Chen M, Dukic T, Mossahebi S, Rodrigues DB, Mahmood J, Vujaskovic Z, Shukla HD. Singh P, et al. Int J Radiat Biol. 2021;97(12):1675-1686. doi: 10.1080/09553002.2021.1976861. Epub 2021 Sep 29. Int J Radiat Biol. 2021. PMID: 34495790
CONCLUSION: We found that Hyperthermia (HT) combined with Proton Beam Radiation (PBRT) could significantly increase chordoma cell death by activating the death receptor pathway and apoptosis which has the promise to treat metastatic chordoma....
CONCLUSION: We found that Hyperthermia (HT) combined with Proton Beam Radiation (PBRT) could significantly increase chordoma cell death by a …
Results of salvage treatment with CyberKnife® fractioned radiosurgery in recurrent large chordoma.
Berber T, Numanoğlu Ç, Uysal E, Dinçer S, Yıldırım BA. Berber T, et al. Eur Spine J. 2023 Jan;32(1):244-253. doi: 10.1007/s00586-022-07399-1. Epub 2022 Sep 30. Eur Spine J. 2023. PMID: 36180739
METHODS: All patients who were referred to Okmeydani Education and Research Hospital between 2012 and 2019 for treatment of recurrent or metastatic chordoma and considered not suitable for surgical treatment were included in the study. We included patients presentin …
METHODS: All patients who were referred to Okmeydani Education and Research Hospital between 2012 and 2019 for treatment of recurrent or …
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma.
Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. Davies JM, et al. J Neurosurg. 2014 Feb;120(2):331-6. doi: 10.3171/2013.10.JNS13598. Epub 2013 Nov 29. J Neurosurg. 2014. PMID: 24286145 Free PMC article.
OBJECT: The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development of novel therapeutic options for chordoma. ...
OBJECT: The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models wo …
Imatinib in advanced chordoma: A retrospective case series analysis.
Hindi N, Casali PG, Morosi C, Messina A, Palassini E, Pilotti S, Tamborini E, Radaelli S, Gronchi A, Stacchiotti S. Hindi N, et al. Eur J Cancer. 2015 Nov;51(17):2609-14. doi: 10.1016/j.ejca.2015.07.038. Epub 2015 Aug 14. Eur J Cancer. 2015. PMID: 26283036
CONCLUSIONS: We confirm the activity of imatinib in locally advanced and metastatic chordoma, in terms of >70% tumour growth arrest in previously progressive patients. ...
CONCLUSIONS: We confirm the activity of imatinib in locally advanced and metastatic chordoma, in terms of >70% tumour growt …
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma.
Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F, Duan Z. Feng Y, et al. Oncotarget. 2015 May 10;6(13):11139-49. doi: 10.18632/oncotarget.3576. Oncotarget. 2015. PMID: 25871477 Free PMC article.
Across nine human chordoma tissue samples, PD-L1 protein was differentially expressed. 94.9% of chordoma samples showed positive PD-L1 expression in the TMA. The expression score of PD-L1 for metastatic chordoma tumors was significant higher as compared with non- …
Across nine human chordoma tissue samples, PD-L1 protein was differentially expressed. 94.9% of chordoma samples showed positive PD-L1 expre …
Suitability of the CellientTM cell block method for diagnosing soft tissue and bone tumors.
Song W, van Hemel BM, Suurmeijer AJH. Song W, et al. Diagn Cytopathol. 2018 Apr;46(4):299-305. doi: 10.1002/dc.23887. Epub 2018 Jan 10. Diagn Cytopathol. 2018. PMID: 29318761 Free PMC article.
In the group of 12 secondary tumors, SATB2 was visualized in metastatic osteosarcoma, whereas expression of S-100 was present in 2 secondary chondrosarcomas. Metastatic chordoma could be confirmed by brachyury expression. Two metastatic alveolar rhabdomyosarcomas we …
In the group of 12 secondary tumors, SATB2 was visualized in metastatic osteosarcoma, whereas expression of S-100 was present in 2 secondary …
Resources Required for Semi-Automatic Volumetric Measurements in Metastatic Chordoma: Is Potentially Improved Tumor Burden Assessment Worth the Time Burden?
Fenerty KE, Patronas NJ, Heery CR, Gulley JL, Folio LR. Fenerty KE, et al. J Digit Imaging. 2016 Jun;29(3):357-64. doi: 10.1007/s10278-015-9846-9. J Digit Imaging. 2016. PMID: 26596767 Free PMC article.
We estimated times for a research assistant to segment all primary and metastatic chordoma lesions using semi-automated volumetric segmentation tools available within our PACS (v12.0, Carestream, Rochester, NY), as well as time required for radiologists to validate …
We estimated times for a research assistant to segment all primary and metastatic chordoma lesions using semi-automated volume …
Phase II study of 9-nitro-camptothecin in patients with advanced chordoma or soft tissue sarcoma.
Chugh R, Dunn R, Zalupski MM, Biermann JS, Sondak VK, Mace JR, Leu KM, Chandler WF, Baker LH. Chugh R, et al. J Clin Oncol. 2005 May 20;23(15):3597-604. doi: 10.1200/JCO.2005.02.170. J Clin Oncol. 2005. PMID: 15908670 Clinical Trial.
PATIENTS AND METHODS: Patients with locally advanced and/or metastatic chordoma, STS, or GIST received 9-NC 1.25 mg/m2 orally for 5 consecutive days followed by 2 days of rest. ...CONCLUSION: 9-NC has modest activity in delaying progression in patients with unresect …
PATIENTS AND METHODS: Patients with locally advanced and/or metastatic chordoma, STS, or GIST received 9-NC 1.25 mg/m2 orally …
11 results