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MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma.
Ho IL, Kuo KL, Liu SH, Chang HC, Hsieh JT, Wu JT, Chiang CK, Lin WC, Tsai YC, Chou CT, Hsu CH, Pu YS, Shi CS, Huang KH. Ho IL, et al. Sci Rep. 2015 Nov 23;5:16948. doi: 10.1038/srep16948. Sci Rep. 2015. PMID: 26592553 Free PMC article.
Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial carcinoma. However, the response rate is only 40-65%. ...MLN4924 also potentiated the cisplatin-induced apoptosis and activation of caspase-3 and -7, phospho-histon …
Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial carcinoma. However, the …
Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors.
Jimenez RE, Hussain M, Bianco FJ Jr, Vaishampayan U, Tabazcka P, Sakr WA, Pontes JE, Wood DP Jr, Grignon DJ. Jimenez RE, et al. Clin Cancer Res. 2001 Aug;7(8):2440-7. Clin Cancer Res. 2001. PMID: 11489824
CONCLUSIONS: Her-2/neu overexpression in primary or metastatic tumor did not predict survival in this cohort of muscle-invasive tumors. Overexpression in the primary tumors consistently predicts overexpression in a distant or regional metastasis. ...Her-2/neu analys …
CONCLUSIONS: Her-2/neu overexpression in primary or metastatic tumor did not predict survival in this cohort of muscle-invasive tumor …
Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD. Tsao CK, et al. Clin Genitourin Cancer. 2012 Mar;10(1):15-20. doi: 10.1016/j.clgc.2011.10.004. Epub 2011 Nov 29. Clin Genitourin Cancer. 2012. PMID: 22130294
METHODS: All patients pathologically diagnosed with muscle invasive and/or metastatic bladder urothelial carcinoma (T2-4, N or M positive) at Mount Sinai Medical Center between January 1, 2000, and January 27, 2011, were identified. ...
METHODS: All patients pathologically diagnosed with muscle invasive and/or metastatic bladder urothelial carcinoma …