Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM.
Kesari S, et al.
Sci Rep. 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4.
Sci Rep. 2023.
PMID: 37147496
Free PMC article.
Eighty-four percent of chordoma samples had loss of TS expression which may predict response to anti-folates. Pemetrexed suppresses tumor growth by inhibiting enzymes involved in folate metabolism, resulting in decreased availability of thymidine which is necessary for DNA …
Eighty-four percent of chordoma samples had loss of TS expression which may predict response to anti-folates. Pemetrexed suppresses t …