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Quoted phrase not found in phrase index: "Microsatellite Stable Endometrial Carcinoma"
Page 1
Practical guidance for mismatch repair-deficiency testing in endometrial cancer.
Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, Bosse T. Stelloo E, et al. Ann Oncol. 2017 Jan 1;28(1):96-102. doi: 10.1093/annonc/mdw542. Ann Oncol. 2017. PMID: 27742654 Free article.
PATIENTS AND METHODS: Six hundred ninety- six endometrial cancers were analyzed for MSI (pentaplex panel) and MMR protein expression (IHC). ...Ambiguous cases (n = 41, 6%) included: subclonal loss of MMR protein expression (n = 18), microsatellite stable or M …
PATIENTS AND METHODS: Six hundred ninety- six endometrial cancers were analyzed for MSI (pentaplex panel) and MMR protein expression …
Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts.
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT. Stelloo E, et al. Clin Cancer Res. 2016 Aug 15;22(16):4215-24. doi: 10.1158/1078-0432.CCR-15-2878. Epub 2016 Mar 22. Clin Cancer Res. 2016. PMID: 27006490
PURPOSE: Recommendations for adjuvant treatment for women with early-stage endometrial carcinoma are based on clinicopathologic features. Comprehensive genomic characterization defined four subgroups: p53-mutant, microsatellite instability (MSI), POLE-mutant, …
PURPOSE: Recommendations for adjuvant treatment for women with early-stage endometrial carcinoma are based on clinicopathologi …
Immune checkpoint inhibitors in endometrial cancer.
Gómez-Raposo C, Merino Salvador M, Aguayo Zamora C, García de Santiago B, Casado Sáenz E. Gómez-Raposo C, et al. Crit Rev Oncol Hematol. 2021 May;161:103306. doi: 10.1016/j.critrevonc.2021.103306. Epub 2021 Apr 8. Crit Rev Oncol Hematol. 2021. PMID: 33839243 Review.
The incidence of endometrial cancer (EC) is increasing worldwide. The prognosis for patients diagnosed with early-stage remains good, whereas for patients with recurrent or metastatic disease, the prognosis is poor and treatment options, until recently, were limited. ...In …
The incidence of endometrial cancer (EC) is increasing worldwide. The prognosis for patients diagnosed with early-stage remains good, …
Molecular characterization of endometrial cancer and therapeutic implications.
Winterhoff B, Thomaier L, Mullany S, Powell MA. Winterhoff B, et al. Curr Opin Obstet Gynecol. 2020 Feb;32(1):76-83. doi: 10.1097/GCO.0000000000000602. Curr Opin Obstet Gynecol. 2020. PMID: 31851045 Review.
PURPOSE OF REVIEW: The present article reviews molecular subtyping and genomic characterization of endometrial carcinoma, and the associated therapeutic and prognostic implications. ...Four distinct subgroups have been identified: polymerase (POLE) ultramutated, …
PURPOSE OF REVIEW: The present article reviews molecular subtyping and genomic characterization of endometrial carcinoma, and …
Microsatellite instability and oncological outcomes in Thai patients with endometrial cancer.
Atjimakul T, Wattanapaisal P, Suwiwat S, Wanichsuwan W, Hanprasertpong J. Atjimakul T, et al. J Obstet Gynaecol. 2022 Oct;42(7):3117-3123. doi: 10.1080/01443615.2022.2106557. Epub 2022 Aug 5. J Obstet Gynaecol. 2022. PMID: 35930016
Here, we determined the frequency of microsatellite instability (MSI) and the impact of MSI-high (MSI-H) on clinical outcomes of Thai patients with endometrial cancer (EC). ...Our study showed that the prevalence of MMR gene deficiency in Thai patients with EC is co …
Here, we determined the frequency of microsatellite instability (MSI) and the impact of MSI-high (MSI-H) on clinical outcomes of Thai …
Discordant Staining Patterns and Microsatellite Results in Tumors of MSH6 Pathogenic Variant Carriers.
van der Werf-'t Lam AS, Terlouw D, Tops CM, van Kan MS, van Hest LP, Gille HJP, Duijkers FAM, Wagner A, Eikenboom EL, Letteboer TGW, de Jong MM, Bajwa-Ten Broeke SW, Bleeker FE, Gomez Garcia EB, de Wind N, van Wezel JT, Morreau H, Suerink M, Nielsen M. van der Werf-'t Lam AS, et al. Mod Pathol. 2023 Sep;36(9):100240. doi: 10.1016/j.modpat.2023.100240. Epub 2023 Jun 10. Mod Pathol. 2023. PMID: 37307877 Free article.
Diagnosis of Lynch syndrome (LS) caused by a pathogenic germline MSH6 variant may be complicated by discordant immunohistochemistry (IHC) and/or by a microsatellite stable (MSS) phenotype. This study aimed to identify the various causes of the discordant phenotypes …
Diagnosis of Lynch syndrome (LS) caused by a pathogenic germline MSH6 variant may be complicated by discordant immunohistochemistry (IHC) an …
The emerging genomic landscape of endometrial cancer.
Le Gallo M, Bell DW. Le Gallo M, et al. Clin Chem. 2014 Jan;60(1):98-110. doi: 10.1373/clinchem.2013.205740. Epub 2013 Oct 29. Clin Chem. 2014. PMID: 24170611 Free PMC article. Review.
It is a heterogeneous disease comprising multiple histologic subtypes. In the US, the majority of deaths from endometrial carcinoma are attributed to the serous and endometrioid subtypes. ...We then review very recent comprehensive and systematic surveys of genomic, …
It is a heterogeneous disease comprising multiple histologic subtypes. In the US, the majority of deaths from endometrial carcinom …
Reclassifying endometrial carcinomas with a combined morphological and molecular approach.
Carlson J, McCluggage WG. Carlson J, et al. Curr Opin Oncol. 2019 Sep;31(5):411-419. doi: 10.1097/CCO.0000000000000560. Curr Opin Oncol. 2019. PMID: 31261170 Review.
PURPOSE OF REVIEW: Currently, endometrial carcinoma diagnosis is based on morphology, often supplemented by immunohistochemistry. ...This revealed that endometrial carcinoma consists of four intrinsic molecular subtypes: POLE (ultramutated), microsa …
PURPOSE OF REVIEW: Currently, endometrial carcinoma diagnosis is based on morphology, often supplemented by immunohistochemist …
Adoption of Universal Testing in Endometrial Cancers for Microsatellite Instability Using Next-Generation Sequencing.
Rodriguez IV, Strickland S, Wells D, Manhardt E, Konnick EQ, Garcia R, Swisher E, Kilgore M, Norquist B. Rodriguez IV, et al. JCO Precis Oncol. 2023 Sep;7:e2300033. doi: 10.1200/PO.23.00033. JCO Precis Oncol. 2023. PMID: 37856764
PURPOSE: To assess implementation of a next-generation sequencing (NGS) assay to detect microsatellite instability (MSI) as a screen for Lynch syndrome (LS) in endometrial cancer (EC), while determining and comparing characteristics of the four molecular subtypes. . …
PURPOSE: To assess implementation of a next-generation sequencing (NGS) assay to detect microsatellite instability (MSI) as a screen …
Pembrolizumab plus lenvatinib combination therapy for advanced endometrial carcinoma.
Walker CA, Spirtos AN, Miller DS. Walker CA, et al. Expert Rev Anticancer Ther. 2023 Apr;23(4):361-368. doi: 10.1080/14737140.2023.2194634. Epub 2023 Mar 28. Expert Rev Anticancer Ther. 2023. PMID: 36944439 Review.
INTRODUCTION: Advanced and recurrent endometrial carcinoma remains a difficult diagnosis to treat due to the limited and ineffective available treatment options following platinum and taxane chemotherapy. Patients who are microsatellite stable (MSS) or …
INTRODUCTION: Advanced and recurrent endometrial carcinoma remains a difficult diagnosis to treat due to the limited and ineff …
69 results