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The ERM protein moesin regulates natural killer cell homeostasis in vivo.
Satooka H, Matsui M, Ichioka S, Nakamura Y, Hirata T. Satooka H, et al. Cell Immunol. 2022 Jan;371:104456. doi: 10.1016/j.cellimm.2021.104456. Epub 2021 Nov 13. Cell Immunol. 2022. PMID: 34798556
Hemizygous mutations in the X-linked moesin gene are associated with primary immunodeficiency with T and B cell lymphopenia, which also affects natural killer (NK) cells in most cases. We previously showed that moesin deficiency in mice substantially affects lymphoc …
Hemizygous mutations in the X-linked moesin gene are associated with primary immunodeficiency with T and B cell lymphopenia, which also affe …
Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis.
Hirata T, Nomachi A, Tohya K, Miyasaka M, Tsukita S, Watanabe T, Narumiya S. Hirata T, et al. Int Immunol. 2012 Nov;24(11):705-17. doi: 10.1093/intimm/dxs077. Epub 2012 Aug 8. Int Immunol. 2012. PMID: 22875842
This phenotype was recapitulated in bone marrow (BM) chimeras with a hematopoietic moesin deficiency. Although the T and B cells apparently developed without major defects in the moesin-deficient mice, T cell egress from the thymus and immature B cell egress from th …
This phenotype was recapitulated in bone marrow (BM) chimeras with a hematopoietic moesin deficiency. Although the T and B cel …
Exome Sequencing Diagnoses X-Linked Moesin-Associated Immunodeficiency in a Primary Immunodeficiency Case.
Bradshaw G, Lualhati RR, Albury CL, Maksemous N, Roos-Araujo D, Smith RA, Benton MC, Eccles DA, Lea RA, Sutherland HG, Haupt LM, Griffiths LR. Bradshaw G, et al. Front Immunol. 2018 Mar 5;9:420. doi: 10.3389/fimmu.2018.00420. eCollection 2018. Front Immunol. 2018. PMID: 29556235 Free PMC article.
Western Blot analysis demonstrated an absence of moesin protein in lymphocytes derived from the proband, compared with normal expression in lymphocytes derived from the healthy control, father and mother. qPCR identified significantly lower MSN mRNA transcript expression in the p …
Western Blot analysis demonstrated an absence of moesin protein in lymphocytes derived from the proband, compared with normal expression in …
Advanced glycation endproducts mediate chronic kidney injury with characteristic patterns in different stages.
Huang X, Li B, Hu J, Liu Z, Li D, Chen Z, Huang H, Chen Y, Guo X, Cui Y, Huang Q. Huang X, et al. Front Physiol. 2022 Sep 9;13:977247. doi: 10.3389/fphys.2022.977247. eCollection 2022. Front Physiol. 2022. PMID: 36160865 Free PMC article.
Moreover, moesin phosphorylation was accompanied by AGE-BSA-induced alterations and moesin deficiency in mice attenuated by AGE-BSA-induced fibrosis. ...
Moreover, moesin phosphorylation was accompanied by AGE-BSA-induced alterations and moesin deficiency in mice attenuated by AG …