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149 results

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Quoted phrase not found in phrase index: "Monoclonal elevation of IgG"
Page 1
Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial.
Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS, Theess W, Yang X, Staton TL, Choy DF, Fong A, Dash A, Dolton M, Pappu R, Brightling CE. Kelsen SG, et al. J Allergy Clin Immunol. 2021 Sep;148(3):790-798. doi: 10.1016/j.jaci.2021.03.044. Epub 2021 Apr 16. J Allergy Clin Immunol. 2021. PMID: 33872652 Free article. Clinical Trial.
Inhaled allergens, pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL-33, an epithelial-derived "alarmin." Astegolimab, a human IgG(2) mAb, selectively inhibits the IL-33 receptor, ST2. Approved biologic therapies for severe asthm …
Inhaled allergens, pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL-33, an epithelial-derived " …
Pemphigus: Current and Future Therapeutic Strategies.
Didona D, Maglie R, Eming R, Hertl M. Didona D, et al. Front Immunol. 2019 Jun 25;10:1418. doi: 10.3389/fimmu.2019.01418. eCollection 2019. Front Immunol. 2019. PMID: 31293582 Free PMC article. Review.
The disease usually runs a chronic-relapsing course, with a potentially devastating impact on the patients' quality of life. Pemphigus pathogenesis is related to IgG autoantibodies targeting various adhesion molecules in the epidermis, including desmoglein (Dsg) 1 and 3, m …
The disease usually runs a chronic-relapsing course, with a potentially devastating impact on the patients' quality of life. Pemphigus patho …
Schnitzler's syndrome: diagnosis, treatment, and follow-up.
Simon A, Asli B, Braun-Falco M, De Koning H, Fermand JP, Grattan C, Krause K, Lachmann H, Lenormand C, Martinez-Taboada V, Maurer M, Peters M, Rizzi R, Rongioletti F, Ruzicka T, Schnitzler L, Schubert B, Sibilia J, Lipsker D. Simon A, et al. Allergy. 2013;68(5):562-8. doi: 10.1111/all.12129. Epub 2013 Mar 9. Allergy. 2013. PMID: 23480774 Review.
A diagnosis of Schnitzler's syndrome is considered definite in any patient with two obligate criteria: a recurrent urticarial rash and a monoclonal IgM gammopathy, and two of the following minor criteria: recurrent fever, objective signs of abnormal bone remodeling, ele …
A diagnosis of Schnitzler's syndrome is considered definite in any patient with two obligate criteria: a recurrent urticarial rash and a …
Monoclonal gammopathy of undetermined significance and smouldering multiple myeloma: emphasis on risk factors for progression.
Kyle RA, Rajkumar SV. Kyle RA, et al. Br J Haematol. 2007 Dec;139(5):730-43. doi: 10.1111/j.1365-2141.2007.06873.x. Br J Haematol. 2007. PMID: 18021088 Free article. Review.
Monoclonal gammopathy of undetermined significance (MGUS) is characterized by a serum monoclonal protein <30 g/l, <10% plasma cells in the bone marrow, and absence of end-organ damage (CRAB-hypercalcaemia, renal insufficiency, anaemia, or bone lesions). ...Smo …
Monoclonal gammopathy of undetermined significance (MGUS) is characterized by a serum monoclonal protein <30 g/l, <10% p …
Attack adjudication in neuromyelitis optica spectrum disorder: Substantiation of criteria by magnetic resonance imaging and biomarkers in N-MOmentum.
Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BA. Weinshenker BG, et al. Mult Scler. 2023 Jul;29(8):945-955. doi: 10.1177/13524585231172145. Epub 2023 Jun 6. Mult Scler. 2023. PMID: 37282545 Free PMC article. Clinical Trial.
CONCLUSION: AC adjudication of NMOSD attacks according to predefined criteria appears robust. MRI lesion correlates and sGFAP elevations were found in most adjudicated attacks....
CONCLUSION: AC adjudication of NMOSD attacks according to predefined criteria appears robust. MRI lesion correlates and sGFAP elevations …
Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation.
Bharadwaj P, Shrestha S, Pongracz T, Concetta C, Sharma S, Le Moine A, de Haan N, Murakami N, Riella LV, Holovska V, Wuhrer M, Marchant A, Ackerman ME. Bharadwaj P, et al. Cell Rep Med. 2022 Nov 15;3(11):100818. doi: 10.1016/j.xcrm.2022.100818. Cell Rep Med. 2022. PMID: 36384101 Free PMC article.
Levels of afucosylated anti-A2 antibodies are elevated in seropositive patients, especially those with AMR, suggesting potential cytotoxicity via FcgammaRIII-mediated mechanisms. Afucosylation of both glycoengineered monoclonal and naturally glycovariant polyclonal …
Levels of afucosylated anti-A2 antibodies are elevated in seropositive patients, especially those with AMR, suggesting potential cyto …
Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.
Wen J, Wang W, Xu F, Chen J, Zhang M, Cheng D, Ni X, Li X, Liu Z. Wen J, et al. BMC Nephrol. 2018 Jul 11;19(1):173. doi: 10.1186/s12882-018-0969-3. BMC Nephrol. 2018. PMID: 29996809 Free PMC article.
BACKGROUND: We present a case series of 5 patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) of renal allografts to better define its natural history, presenting characteristics, pathological features and treatment outcome. ...Immun …
BACKGROUND: We present a case series of 5 patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) …
Disease associations with isolated elevations of each of the four IgG subclasses.
Engelhart S, Glynn RJ, Schur PH. Engelhart S, et al. Semin Arthritis Rheum. 2017 Oct;47(2):276-280. doi: 10.1016/j.semarthrit.2017.03.021. Epub 2017 Mar 30. Semin Arthritis Rheum. 2017. PMID: 28457528
In this retrospective chart review study, we aim to address that gap, by exploring disease associations in patients with isolated IgG subclass elevations. METHODS: We identified 552 patients with an isolated elevation of one of the IgG subclasses, and …
In this retrospective chart review study, we aim to address that gap, by exploring disease associations in patients with isolated IgG …
Immunoglobulinopathies in patients with angioimmunoblastic T-cell lymphoma.
Chernova NG, Soboleva NP, Mariina SA, Sidorova YV, Sinitsyna MN, Dvirnyk VN, Badmazhapova DS, Vinogradova YE, Zvonkov EE, Savchenko VG. Chernova NG, et al. Ter Arkh. 2018 Aug 17;90(7):51-56. doi: 10.26442/terarkh201890751-56. Ter Arkh. 2018. PMID: 30701922
The detected immunoglobulinopathies were divided into 4 groups: polyclonal hypergammaglobulinaemia, hypogammaglobulinaemia, oligoclonal gammapathy, and monoclonal gammapathy. Polyclonal hypergammaglobulinaemia was marked in 41 (74.5%) of 55 pts, elevated level of …
The detected immunoglobulinopathies were divided into 4 groups: polyclonal hypergammaglobulinaemia, hypogammaglobulinaemia, oligoclonal gamm …
Prevalence of IgG and Neutralizing Antibodies against Staphylococcus aureus Alpha-Toxin in Healthy Human Subjects and Diverse Patient Populations.
Wu Y, Liu X, Akhgar A, Li JJ, Mok H, Sellman BR, Yu L, Roskos LK, Esser MT, Ruzin A. Wu Y, et al. Infect Immun. 2018 Feb 20;86(3):e00671-17. doi: 10.1128/IAI.00671-17. Print 2018 Mar. Infect Immun. 2018. PMID: 29263109 Free PMC article.
Anti-AT IgG levels were slightly higher in S. aureus-colonized subjects than in noncolonized subjects. ...These data demonstrate that AT elicits a robust IgG humoral response in infants and young children that becomes stable prior to adolescence, matures into higher …
Anti-AT IgG levels were slightly higher in S. aureus-colonized subjects than in noncolonized subjects. ...These data demonstrate that …
149 results