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38 results

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Page 1
Prognostic Implications of Monosomies in Patients With Multiple Myeloma.
Shin SY, Eom HS, Sohn JY, Lee H, Park B, Joo J, Jang JH, Lee MN, Kim JK, Kong SY. Shin SY, et al. Clin Lymphoma Myeloma Leuk. 2017 Mar;17(3):159-164.e2. doi: 10.1016/j.clml.2016.12.001. Epub 2016 Dec 26. Clin Lymphoma Myeloma Leuk. 2017. PMID: 28089441
Although several cytogenetic aberrations have been reported to be prognostic, less is known about the association between the presence of monosomies and prognosis. ...The prognostic effect of monosomies was evaluated by comparison with the clinical factors in …
Although several cytogenetic aberrations have been reported to be prognostic, less is known about the association between the presenc …
Prognostic significance of acquired 1q22 gain in multiple myeloma.
Audil HY, Cook JM, Greipp PT, Kapoor P, Baughn LB, Dispenzieri A, Gertz MA, Buadi FK, Lacy MQ, Dingli D, Fonder AL, Hayman SR, Hobbs MA, Muchtar E, Siddiqui M, Gonsalves WI, Hwa YL, Leung N, Lin Y, Kourelis TV, Warsame R, Kyle RA, Ketterling RP, Rajkumar SV, Kumar SK. Audil HY, et al. Am J Hematol. 2022 Jan 1;97(1):52-59. doi: 10.1002/ajh.26391. Epub 2021 Nov 3. Am J Hematol. 2022. PMID: 34710241 Free article.
Gain of 1q22 at diagnosis portends poorer outcomes in multiple myeloma (MM), but the prognostic significance of acquired 1q22 gain is unknown. We identified 63 MM patients seen at Mayo Clinic from 1/2004 to 12/2019 without 1q22 gain at diagnosis who acquired it during foll …
Gain of 1q22 at diagnosis portends poorer outcomes in multiple myeloma (MM), but the prognostic significance of acquired 1q22 gain is …
Cytogenetic Abnormalities in Multiple Myeloma Patients at a Tertiary Healthcare Center in India.
Govindasamy P, Pandurangan P, Tarigopula A, Mani R, R Samuel C. Govindasamy P, et al. Asian Pac J Cancer Prev. 2019 Jan 25;20(1):235-241. doi: 10.31557/APJCP.2019.20.1.235. Asian Pac J Cancer Prev. 2019. PMID: 30678438 Free PMC article.
Objective: Multiple myeloma (MM) is a clinically and genetically heterogeneous plasma cell neoplasm. The prognosis of MM patients is dependent on several factors including the patient's age, the stage of disease and genetic alterations. ...
Objective: Multiple myeloma (MM) is a clinically and genetically heterogeneous plasma cell neoplasm. The prognosis of MM patients is …
DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome.
Todoerti K, Ronchetti D, Favasuli V, Maura F, Morabito F, Bolli N, Taiana E, Neri A. Todoerti K, et al. Haematologica. 2022 Apr 1;107(4):921-932. doi: 10.3324/haematol.2021.278342. Haematologica. 2022. PMID: 33951891 Free PMC article.
In particular, bi-allelic DIS3 lesions significantly affected progression-free survival, independently of other predictors of poor clinical outcome, while mono-allelic events mostly affected overall survival. As expected, DIS3 mutations affect the MM transcriptome involvin …
In particular, bi-allelic DIS3 lesions significantly affected progression-free survival, independently of other predictors of poor cl …
Trisomy/partial monosomy 13 mosaicism associated with relatively mild clinical malformation.
Duckett DP, Porter HJ, Young ID. Duckett DP, et al. Ann Genet. 1992;35(2):113-6. Ann Genet. 1992. PMID: 1524408 Review.
On termination this case, together with apparently the only other three reported cytogenetically similar cases, was found to have much less severe clinical abnormalities than might have been predicted. The possibility in these cases that the effects of the trisomy and mono …
On termination this case, together with apparently the only other three reported cytogenetically similar cases, was found to have much less …
Close relation between 14q32/IGH translocations and chromosome 13 abnormalities in multiple myeloma: a high incidence of 11q13/CCND1 and 16q23/MAF.
Takimoto M, Ogawa K, Kato Y, Saito T, Suzuki T, Irei M, Shibuya Y, Suzuki Y, Kato M, Inoue Y, Takahashi M, Sugimori H, Miura I. Takimoto M, et al. Int J Hematol. 2008 Apr;87(3):260-5. doi: 10.1007/s12185-008-0039-x. Epub 2008 Feb 16. Int J Hematol. 2008. PMID: 18274833
Although 14q32/IGH translocations are closely related to the biological features of MM, the most consistent and powerful prognostic factor has been reported to be the loss of all (monosomy 13/-13) or part of chromosome 13 (del(13)(q14)/13q-). ...
Although 14q32/IGH translocations are closely related to the biological features of MM, the most consistent and powerful prognostic f …
Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13.
Avet-Louseau H, Daviet A, Sauner S, Bataille R; Intergroupe Francophone du Myélome. Avet-Louseau H, et al. Br J Haematol. 2000 Dec;111(4):1116-7. doi: 10.1046/j.1365-2141.2000.02488.x. Br J Haematol. 2000. PMID: 11227093 Free article.
Chromosome 13 abnormalities are frequently observed in multiple myeloma (MM). Several reports recently demonstrated the strong prognostic value of these abnormalities, associated with a short survival. ...
Chromosome 13 abnormalities are frequently observed in multiple myeloma (MM). Several reports recently demonstrated the strong prognostic …
Plasma cell myeloma with RAS/BRAF mutations is frequently associated with a complex karyotype, advanced stage disease, and poorer prognosis.
Li N, Lin P, Zuo Z, You MJ, Shuai W, Orlowski R, Manasanch EE, Li S, Xu J, Garces S, Jelloul FZ, Tang Z, Wang W, Medeiros LJ, Yin CC. Li N, et al. Cancer Med. 2023 Jul;12(13):14293-14304. doi: 10.1002/cam4.6103. Epub 2023 May 22. Cancer Med. 2023. PMID: 37212518 Free PMC article.
BACKGROUND: Mutations in the RAS-MAPK pathway, such as KRAS, NRAS, and BRAF, are known as high-risk factors associated with poor prognosis in patients with various cancers, but studies in myeloma have yielded mixed results. ...Univariate analysis revealed that KRAS mutatio …
BACKGROUND: Mutations in the RAS-MAPK pathway, such as KRAS, NRAS, and BRAF, are known as high-risk factors associated with poor prognosi …
38 results