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Page 1
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group. Strickland SA, et al. Leuk Res. 2017 Aug;59:55-64. doi: 10.1016/j.leukres.2017.05.010. Epub 2017 May 12. Leuk Res. 2017. PMID: 28551161 Free PMC article. Clinical Trial.
Monosomy 7 demonstrated no impact on OS in patients with CK5 (p=0.39) or CK4 (p=0.44). Monosomy 17 appeared in 43% (68/158) of CK5 patients and demonstrated statistically significant worse OS (0.4y) compared to CK5 patients without monosomy 17 (0.5y; p …
Monosomy 7 demonstrated no impact on OS in patients with CK5 (p=0.39) or CK4 (p=0.44). Monosomy 17 appeared in 43% (68/158) of …
Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study.
Baranwal A, Chhetri R, Yeung D, Clark M, Shah S, Litzow MR, Hogan WJ, Mangaonkar A, Alkhateeb HB, Singhal D, Cibich A, Bardy P, Kok CH, Hiwase DK, Shah MV. Baranwal A, et al. Bone Marrow Transplant. 2023 Jul;58(7):769-776. doi: 10.1038/s41409-023-01970-0. Epub 2023 Apr 3. Bone Marrow Transplant. 2023. PMID: 37012415
In t-MDS, the presence of monosomy 5 (HR 3.63, P = 0.006) or monosomy 17 (HR 11.81, P = 0.01) pre-alloSCT were associated with higher RI. ...
In t-MDS, the presence of monosomy 5 (HR 3.63, P = 0.006) or monosomy 17 (HR 11.81, P = 0.01) pre-alloSCT were associated with …
Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia.
Yoshida S, Onozawa M, Miyashita N, Kimura H, Takahashi S, Yokoyama S, Matsukawa T, Hirabayashi S, Mori A, Hidaka D, Minauchi K, Shigematsu A, Hashiguchi J, Igarashi T, Kakinoki Y, Tsutsumi Y, Ibata M, Kobayashi H, Haseyama Y, Fujimoto K, Ishihara T, Sakai H, Ota S, Kondo T, Teshima T. Yoshida S, et al. Int J Hematol. 2023 Apr;117(4):544-552. doi: 10.1007/s12185-022-03522-6. Epub 2022 Dec 26. Int J Hematol. 2023. PMID: 36572814 Free article.
Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.009). Among patients with typical CK-AML, those with monosomy 17 or deletion of 17p had significantly shorter OS than patients w …
Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.00 …
"Double-hit" chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain.
Chapiro E, Lesty C, Gabillaud C, Durot E, Bouzy S, Armand M, Le Garff-Tavernier M, Bougacha N, Struski S, Bidet A, Laharanne E, Barin C, Veronese L, Prié N, Eclache V, Gaillard B, Michaux L, Lefebvre C, Gaillard JB, Terré C, Penther D, Bastard C, Nadal N, Fert-Ferrer S, Auger N, Godon C, Sutton L, Tournilhac O, Susin SA, Nguyen-Khac F; GroupeFrancophone de Cytogénétique Hématologique(GFCH) and the French Innovative Leukemia Organization (FILO) group. Chapiro E, et al. Am J Hematol. 2018 Mar;93(3):375-382. doi: 10.1002/ajh.24990. Epub 2017 Dec 18. Am J Hematol. 2018. PMID: 29194741 Free article.
Loss of 17p resulted primarily from an unbalanced translocation (70%) with several chromosome partners (the most frequent being chromosome 18q), followed by deletion 17p (23%), monosomy 17 (8%), isochromosome 17q [i(17q)] (5%) and a ring chromosome 17 (2%). In a uni …
Loss of 17p resulted primarily from an unbalanced translocation (70%) with several chromosome partners (the most frequent being chromosome 1 …
Differential characteristics of TP53 alterations in pure erythroid leukemia arising after exposure to cytotoxic therapy.
Tashakori M, Wang W, Kadia TM, Daver NG, Montalban-Bravo G, Loghavi S, Wang SA, Medeiros LJ, Ravandi F, Khoury JD. Tashakori M, et al. Leuk Res. 2022 Jul;118:106860. doi: 10.1016/j.leukres.2022.106860. Epub 2022 May 17. Leuk Res. 2022. PMID: 35636055
In the d-PEL group, 9/16 (56.2%) patients had hotspot mutations compared to 2 (22.2%) patients in the t-PEL group. Notably, monosomy 17 or del(17p) were less common in the d-PEL group (26.6%) compared to the t-PEL group (71.4%), underscoring distinctive TP53 alterat …
In the d-PEL group, 9/16 (56.2%) patients had hotspot mutations compared to 2 (22.2%) patients in the t-PEL group. Notably, monosomy …
Hyperhaploidy is a novel high-risk cytogenetic subgroup in multiple myeloma.
Sawyer JR, Tian E, Shaughnessy JD Jr, Epstein J, Swanson CM, Stangeby C, Hale CL, Parr L, Lynn M, Sammartino G, Lukacs JL, Stein C, Bailey C, Zangari M, Davies FE, Van Rhee F, Barlogie B, Morgan GJ. Sawyer JR, et al. Leukemia. 2017 Mar;31(3):637-644. doi: 10.1038/leu.2016.253. Epub 2016 Oct 3. Leukemia. 2017. PMID: 27694925 Free PMC article.
Analysis of clones utilizing interphase fluorescence in situ hybridization (iFISH), metaphase FISH and spectral karyotyping identified either monosomy 17 or del17p in all patients. Amplification of 1q21 was identified in eight patients, demonstrating an additional h …
Analysis of clones utilizing interphase fluorescence in situ hybridization (iFISH), metaphase FISH and spectral karyotyping identified eithe …
Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course.
Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, Gervais C, Nguyen-Khac F, Chapiro E, Radford-Weiss I, Struski S, Dastugue N, Gachard N, Lefebvre C, Barin C, Eclache V, Fert-Ferrer S, Laibe S, Mozziconacci MJ, Quilichini B, Poirel HA, Wlodarska I, Hagemeijer A, Moreau Y, Vandenberghe P, Michaux L; BCGHo and the GFCH. Put N, et al. Ann Hematol. 2012 Jun;91(6):863-73. doi: 10.1007/s00277-011-1393-y. Epub 2011 Dec 30. Ann Hematol. 2012. PMID: 22205151
MYC translocations were frequently observed with concomitant adverse cytogenetic markers, such as del(11q) (n = 8/30) and/or del(17p)/monosomy 17 (n = 7/30). In addition, the presence of unbalanced translocations (n = 24 in 13/30 cases) and complex karyotype (n = 16 …
MYC translocations were frequently observed with concomitant adverse cytogenetic markers, such as del(11q) (n = 8/30) and/or del(17p)/mon …
The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.
Parry TE. Parry TE. Leuk Res. 1997 Jun;21(6):559-74. doi: 10.1016/s0145-2126(97)83221-3. Leuk Res. 1997. PMID: 9279367 Review.
There was no clinical, or haematological difference or difference in survival between ras positive and ras negative patients with acute myeloid leukaemia (AML) in adults or children, but ras mutations carried a poorer prognosis in childhood acute lymphocytic leukaemia and an incr …
There was no clinical, or haematological difference or difference in survival between ras positive and ras negative patients with acute myel …
Complex chromosomal abnormalities in acute nonlymphocytic leukemia.
Levin M, Le Coniat M, Bernheim A, Berger R. Levin M, et al. Cancer Genet Cytogenet. 1986 Jun;22(2):113-9. doi: 10.1016/0165-4608(86)90171-8. Cancer Genet Cytogenet. 1986. PMID: 3708547
Hyperdiploidy and partial or complete monosomy 5 were more frequent in complex de novo ANLL, whereas, hypo or pseudodiploidy and partial or complete monosomy of chromosome #7 were more frequent in secondary ANLL/DMS. Monosomy 17 and partial deletion of the short arm …
Hyperdiploidy and partial or complete monosomy 5 were more frequent in complex de novo ANLL, whereas, hypo or pseudodiploidy and partial or …
Coincident remission of ankylosing spondylitis after autologous stem cell transplantation for multiple myeloma.
Shaikh H, Bakalov V, Shaikh S, Khattab A, Sadashiv S. Shaikh H, et al. J Oncol Pharm Pract. 2021 Jan;27(1):232-234. doi: 10.1177/1078155220927750. Epub 2020 Jun 3. J Oncol Pharm Pract. 2021. PMID: 32493162
Following the achievement of adequate response to induction, she underwent an autologous hematopoietic stem cell transplant selected for CD34+ cells with melphalan 200mg/m(2) conditioning regimen. Given high-risk cytogenetics, i.e. monosomy 17 (17p) and hypodiploidy …
Following the achievement of adequate response to induction, she underwent an autologous hematopoietic stem cell transplant selected for CD3 …
23 results