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Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group. Strickland SA, et al. Leuk Res. 2017 Aug;59:55-64. doi: 10.1016/j.leukres.2017.05.010. Epub 2017 May 12. Leuk Res. 2017. PMID: 28551161 Free PMC article. Clinical Trial.
Monosomy 7 demonstrated no impact on OS in patients with CK5 (p=0.39) or CK4 (p=0.44). Monosomy 17 appeared in 43% (68/158) of CK5 patients and demonstrated statistically significant worse OS (0.4y) compared to CK5 patients without monosomy 17 (0.5y; p …
Monosomy 7 demonstrated no impact on OS in patients with CK5 (p=0.39) or CK4 (p=0.44). Monosomy 17 appeared in 43% (68/158) of …
Characteristics of HER2 Gene Amplification by Fluorescence In Situ Hybridization in Endometrial Serous Carcinoma.
Buza N, Hui P. Buza N, et al. Arch Pathol Lab Med. 2022 Jun 10;146(5):0. doi: 10.5858/arpa.2021-0547-OA. Arch Pathol Lab Med. 2022. PMID: 35687792 Free article.
HER2 IHC was scored according to the proposed endometrial carcinoma-specific algorithm and FISH was evaluated by using the 2018 ESC clinical trial criteria, the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2016 gastric cri …
HER2 IHC was scored according to the proposed endometrial carcinoma-specific algorithm and FISH was evaluated by using the 2018 ESC clini …
Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study.
Baranwal A, Chhetri R, Yeung D, Clark M, Shah S, Litzow MR, Hogan WJ, Mangaonkar A, Alkhateeb HB, Singhal D, Cibich A, Bardy P, Kok CH, Hiwase DK, Shah MV. Baranwal A, et al. Bone Marrow Transplant. 2023 Jul;58(7):769-776. doi: 10.1038/s41409-023-01970-0. Epub 2023 Apr 3. Bone Marrow Transplant. 2023. PMID: 37012415
In t-MDS, the presence of monosomy 5 (HR 3.63, P = 0.006) or monosomy 17 (HR 11.81, P = 0.01) pre-alloSCT were associated with higher RI. ...
In t-MDS, the presence of monosomy 5 (HR 3.63, P = 0.006) or monosomy 17 (HR 11.81, P = 0.01) pre-alloSCT were associated with …
Translocations (5;17) and (7;17) in patients with de novo or therapy-related myelodysplastic syndromes or acute nonlymphocytic leukemia. A possible association with acquired pseudo-Pelger-Huët anomaly and small vacuolated granulocytes.
Laï JL, Zandecki M, Fenaux P, Le Baron F, Bauters F, Cosson A, Deminatti M. Laï JL, et al. Cancer Genet Cytogenet. 1990 Jun;46(2):173-83. doi: 10.1016/0165-4608(90)90102-g. Cancer Genet Cytogenet. 1990. PMID: 2340488
On the other hand, eight patients had a pseudo-Pelger-Huet anomaly, which correlated significantly with total monosomy 17 in these patients. A possible correlation between cytological anomalies and cytogenetic data is discussed, and the role of 17p in the nuclear se …
On the other hand, eight patients had a pseudo-Pelger-Huet anomaly, which correlated significantly with total monosomy 17 in t …
Chromosomal aneusomies detected by fluorescent in situ hybridization analysis in clinically localized prostate carcinoma.
Brown JA, Alcaraz A, Takahashi S, Persons DL, Lieber MM, Jenkins RB. Brown JA, et al. J Urol. 1994 Oct;152(4):1157-62. doi: 10.1016/s0022-5347(17)32527-2. J Urol. 1994. PMID: 8072085 Review.
Fluorescent in situ hybridization using 12 chromosome enumeration probes (for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 17, 18, X and Y) was used to evaluate fresh tumor touch preparations from 40 randomly selected radical prostatectomy specimens. Of the tumors 16 (40%) conta …
Fluorescent in situ hybridization using 12 chromosome enumeration probes (for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 17, 18, X and Y) was us …
Therapy-related myelodysplastic syndrome and acute myeloid leukemia with 17p deletion. A report on 25 cases.
Merlat A, Lai JL, Sterkers Y, Demory JL, Bauters F, Preudhomme C, Fenaux P. Merlat A, et al. Leukemia. 1999 Feb;13(2):250-7. doi: 10.1038/sj.leu.2401298. Leukemia. 1999. PMID: 10025899 Clinical Trial.
Typical dysgranulopoiesis and p53 mutation and/or overexpression were seen in 22 of 24 and 16 of 19 evaluable patients, respectively. 17p deletion resulted from unbalanced translocations involving 17p (18 cases), monosomy 17 (five cases), i(17q) (one case) or del 17 …
Typical dysgranulopoiesis and p53 mutation and/or overexpression were seen in 22 of 24 and 16 of 19 evaluable patients, respectively. 17p de …
Coincident remission of ankylosing spondylitis after autologous stem cell transplantation for multiple myeloma.
Shaikh H, Bakalov V, Shaikh S, Khattab A, Sadashiv S. Shaikh H, et al. J Oncol Pharm Pract. 2021 Jan;27(1):232-234. doi: 10.1177/1078155220927750. Epub 2020 Jun 3. J Oncol Pharm Pract. 2021. PMID: 32493162
Following the achievement of adequate response to induction, she underwent an autologous hematopoietic stem cell transplant selected for CD34+ cells with melphalan 200mg/m(2) conditioning regimen. Given high-risk cytogenetics, i.e. monosomy 17 (17p) and hypodiploidy …
Following the achievement of adequate response to induction, she underwent an autologous hematopoietic stem cell transplant selected for CD3 …
The impact of additional cytogenetic abnormalities at diagnosis and during therapy with tyrosine kinase inhibitors in Chronic Myeloid Leukaemia.
Crisan AM, Coriu D, Arion C, Colita A, Jardan C. Crisan AM, et al. J Med Life. 2015 Oct-Dec;8(4):502-8. J Med Life. 2015. PMID: 26664479 Free PMC article.
MATERIALS AND METHODS: Since 2005 until 2013, the data from the Hematology and Bone Marrow Transplantation Department of Fundeni Clinical Institute was collected. In this observational retrospective single centre study, 28 CML patients with ACAs at diagnosis and during TKI …
MATERIALS AND METHODS: Since 2005 until 2013, the data from the Hematology and Bone Marrow Transplantation Department of Fundeni Clinical …
The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.
Parry TE. Parry TE. Leuk Res. 1997 Jun;21(6):559-74. doi: 10.1016/s0145-2126(97)83221-3. Leuk Res. 1997. PMID: 9279367 Review.
A conventional and a computer search of the literature yielded 627 sequenced point mutations in the ras and p53 genes in 575 patients with leukaemia and myelodysplasia (MDS) out of a total of 4214 investigated. ras Mutations predominated in myeloid leukaemia and were more common …
A conventional and a computer search of the literature yielded 627 sequenced point mutations in the ras and p53 genes in 575 patients with l …
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