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Page 1
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Wells SA Jr, et al. Thyroid. 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335. Thyroid. 2015. PMID: 25810047 Free PMC article. Review.
Prophylactic neck surgery for second-generation multiple endocrine neoplasia type 2B.
Machens A, Lorenz K, Weber F, Dralle H. Machens A, et al. Eur J Surg Oncol. 2021 Apr;47(4):924-927. doi: 10.1016/j.ejso.2020.11.006. Epub 2020 Nov 13. Eur J Surg Oncol. 2021. PMID: 33223415
There is no evidence-based guidance on the extent of prophylactic neck surgery for second-generation multiple endocrine neoplasia type 2B (MEN 2B), a newly emerging entity in the molecular era. ...
There is no evidence-based guidance on the extent of prophylactic neck surgery for second-generation multiple endocrine neo …
Pheochromocytomas in Multiple Endocrine Neoplasia Type 2.
Tsang VH, Tacon LJ, Learoyd DL, Robinson BG. Tsang VH, et al. Recent Results Cancer Res. 2015;204:157-78. doi: 10.1007/978-3-319-22542-5_7. Recent Results Cancer Res. 2015. PMID: 26494388 Review.
Compared to sporadic PC, MEN2-associated PC is more likely to be epinephine secreting and demonstrate bilateral adrenal involvement, and is less likely to be malignant. The diagnosis of PC requires clinical suspicion and biochemical testing, followed by imaging studies. .. …
Compared to sporadic PC, MEN2-associated PC is more likely to be epinephine secreting and demonstrate bilateral adrenal involvement, and is …
Multiple endocrine neoplasia type 2.
Lodish M. Lodish M. Front Horm Res. 2013;41:16-29. doi: 10.1159/000345667. Epub 2013 Mar 19. Front Horm Res. 2013. PMID: 23652668
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal-dominant cancer syndrome characterized by variable penetrance of medullary thyroid carcinoma(MTC), pheochromocytoma (PHEO), and primary hyperparathyroidism (PHPT). MEN2 consists of two clinical subtypes, MEN2A and …
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal-dominant cancer syndrome characterized by variable penetrance of medullary thyroi …
Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features.
Kreps EO, Van Herzeele I, Callewaert BL. Kreps EO, et al. Ophthalmic Genet. 2018 Apr;39(2):268-270. doi: 10.1080/13816810.2017.1408849. Epub 2017 Nov 28. Ophthalmic Genet. 2018. PMID: 29182461
BACKGROUND: To describe ocular and vascular findings in a patient with multiple endocrine neoplasia type 2B. MATERIALS AND METHODS: Case report of a 31-year-old male who was referred for ocular assessment following diagnosis of a carotid artery …
BACKGROUND: To describe ocular and vascular findings in a patient with multiple endocrine neoplasia type 2B …
Surgery for lymph node metastases of medullary thyroid carcinoma: A review.
Jin LX, Moley JF. Jin LX, et al. Cancer. 2016 Feb 1;122(3):358-66. doi: 10.1002/cncr.29761. Epub 2015 Nov 5. Cancer. 2016. PMID: 26539937 Free article. Review.
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells that occurs in hereditary and sporadic clinical settings. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. ...
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells that occurs in hereditary and sporadic clinical …
Late diagnosis of metastatic pheochromocytoma in multiple endocrine neoplasia 2B with rapid clinical decline.
Jester G, Hassanein H, El-Far A. Jester G, et al. BMJ Case Rep. 2021 Feb 4;14(2):e240488. doi: 10.1136/bcr-2020-240488. BMJ Case Rep. 2021. PMID: 33541961 Free PMC article.
Multiple endocrine neoplasia type 2B (MEN2B) is the rarest and most aggressive of the MEN syndromes. ...Imaging showed lymphangitic spread of disease in the lungs. He unfortunately did not respond to a short trial of sunitinib and transit …
Multiple endocrine neoplasia type 2B (MEN2B) is the rarest and most aggressive of the MEN syndromes. ...I …
Drosophila as a novel therapeutic discovery tool for thyroid cancer.
Das T, Cagan R. Das T, et al. Thyroid. 2010 Jul;20(7):689-95. doi: 10.1089/thy.2010.1637. Thyroid. 2010. PMID: 20578898 Review.
ZD6474 (Vandetanib), currently in phase III trials, suppressed tumorigenesis in MEN2 model flies, demonstrating for the first time the effectiveness of a Drosophila-based whole animal model for identifying therapeutically useful compounds. SUMMARY: Clinical data suggest th …
ZD6474 (Vandetanib), currently in phase III trials, suppressed tumorigenesis in MEN2 model flies, demonstrating for the first time the effec …
Update on Pheochromocytoma and Paraganglioma from the SSO Endocrine and Head and Neck Disease Site Working Group, Part 2 of 2: Perioperative Management and Outcomes of Pheochromocytoma and Paraganglioma.
Patel D, Phay JE, Yen TWF, Dickson PV, Wang TS, Garcia R, Yang AD, Kim LT, Solórzano CC. Patel D, et al. Ann Surg Oncol. 2020 May;27(5):1338-1347. doi: 10.1245/s10434-020-08221-2. Epub 2020 Feb 28. Ann Surg Oncol. 2020. PMID: 32112213 Free PMC article. Review.
Vandetanib in children and adolescents with multiple endocrine neoplasia type 2B associated medullary thyroid carcinoma.
Fox E, Widemann BC, Chuk MK, Marcus L, Aikin A, Whitcomb PO, Merino MJ, Lodish M, Dombi E, Steinberg SM, Wells SA, Balis FM. Fox E, et al. Clin Cancer Res. 2013 Aug 1;19(15):4239-48. doi: 10.1158/1078-0432.CCR-13-0071. Epub 2013 Jun 13. Clin Cancer Res. 2013. PMID: 23766359 Free PMC article. Clinical Trial.
Vandetanib, a VEGF and EGF receptor inhibitor, blocks RET tyrosine kinase activity and is active in adults with hereditary MTC. EXPERIMENTAL DESIGN: We conducted a phase I/II trial of vandetanib for children (5-12 years) and adolescents (13-18 years) with MTC to define a r …
Vandetanib, a VEGF and EGF receptor inhibitor, blocks RET tyrosine kinase activity and is active in adults with hereditary MTC. EXPERIMENTAL …
29 results