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Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.
Przespolewski A, Wang ES. Przespolewski A, et al. Expert Opin Investig Drugs. 2016 Jul;25(7):771-80. doi: 10.1080/13543784.2016.1175432. Epub 2016 Apr 21. Expert Opin Investig Drugs. 2016. PMID: 27077938 Review.
Alterations in histone methylation lead to aberrant silencing of expression of multiple genes involved in tumor suppression and cell cycling, resulting in myeloid maturation arrest and proliferation of early myeloid progenitors. ...Currently, multiple oral LS …
Alterations in histone methylation lead to aberrant silencing of expression of multiple genes involved in tumor suppression and cell cycling …
Novel mechanism of G-CSF refractoriness in patients with severe congenital neutropenia.
Druhan LJ, Ai J, Massullo P, Kindwall-Keller T, Ranalli MA, Avalos BR. Druhan LJ, et al. Blood. 2005 Jan 15;105(2):584-91. doi: 10.1182/blood-2004-07-2613. Epub 2004 Sep 7. Blood. 2005. PMID: 15353486 Free article.
Severe congenital neutropenia (SCN) is a rare disease diagnosed at or soon after birth, characterized by a myeloid maturation arrest in the bone marrow, ineffective neutrophil production, and recurrent infections. ...
Severe congenital neutropenia (SCN) is a rare disease diagnosed at or soon after birth, characterized by a myeloid maturation …
Suppression of progenitor cell growth by vancomycin following autologous stem cell transplantation.
Meehan KR, Verma UN, Esteva-Lorenzo F, Mazumder A. Meehan KR, et al. Bone Marrow Transplant. 1997 May;19(10):1029-32. doi: 10.1038/sj.bmt.1700780. Bone Marrow Transplant. 1997. PMID: 9169648

The decrease in the total number of colony-forming units (CFU) was statistically significant at all the dose levels of vancomycin when compared to the number of CFU in the baseline BM sample (P < 0.05). The myeloid maturation arrest observed in the bone ma

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The decrease in the total number of colony-forming units (CFU) was statistically significant at all the dose levels of vancomycin when compa …