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Quoted phrase not found in phrase index: "Narcolepsy 3"
Page 1
Sleep Disorders.
K Pavlova M, Latreille V. K Pavlova M, et al. Am J Med. 2019 Mar;132(3):292-299. doi: 10.1016/j.amjmed.2018.09.021. Epub 2018 Oct 4. Am J Med. 2019. PMID: 30292731 Review.
We review the main diagnostic features of 6 major sleep disorders (insomnia, circadian rhythm disorders, sleep-disordered breathing, hypersomnia/narcolepsy, parasomnias, and restless legs syndrome/periodic limb movement disorder) to aid medical practitioners in screening a …
We review the main diagnostic features of 6 major sleep disorders (insomnia, circadian rhythm disorders, sleep-disordered breathing, hyperso …
Orexin supplementation in narcolepsy treatment: A review.
Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K. Nepovimova E, et al. Med Res Rev. 2019 May;39(3):961-975. doi: 10.1002/med.21550. Epub 2018 Nov 14. Med Res Rev. 2019. PMID: 30426515 Review.
Narcolepsy occurs in approximately 1 of 3000 people, affecting mainly adolescents aged 15 to 30 years. Recently, people with narcolepsy were shown to exhibit extensive orexin/hypocretin neuronal loss. ...
Narcolepsy occurs in approximately 1 of 3000 people, affecting mainly adolescents aged 15 to 30 years. Recently, people with narco …
γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology.
Felmlee MA, Morse BL, Morris ME. Felmlee MA, et al. AAPS J. 2021 Jan 8;23(1):22. doi: 10.1208/s12248-020-00543-z. AAPS J. 2021. PMID: 33417072 Free PMC article. Review.
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid present endogenously in the brain and used therapeutically for the treatment of narcolepsy, as sodium oxybate, and for alcohol abuse/withdrawal. GHB is better known however as a drug of abuse and is commonly referred …
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid present endogenously in the brain and used therapeutically for the treatment of n …
Recently Approved and Upcoming Treatments for Narcolepsy.
Thorpy MJ. Thorpy MJ. CNS Drugs. 2020 Jan;34(1):9-27. doi: 10.1007/s40263-019-00689-1. CNS Drugs. 2020. PMID: 31953791 Free PMC article. Review.
Narcolepsy is a chronic, disabling neurologic disorder characterised by excessive daytime sleepiness (EDS) and, in up to 60% of patients, cataplexy. ...Modulation of gamma-aminobutyric acid B (GABA(B)) receptors or histamine H(3) receptors (H3Rs) has effects on both …
Narcolepsy is a chronic, disabling neurologic disorder characterised by excessive daytime sleepiness (EDS) and, in up to 60% of patie …
A randomized study of solriamfetol for excessive sleepiness in narcolepsy.
Thorpy MJ, Shapiro C, Mayer G, Corser BC, Emsellem H, Plazzi G, Chen D, Carter LP, Wang H, Lu Y, Black J, Dauvilliers Y. Thorpy MJ, et al. Ann Neurol. 2019 Mar;85(3):359-370. doi: 10.1002/ana.25423. Ann Neurol. 2019. PMID: 30694576 Free PMC article. Clinical Trial.
OBJECTIVE: Solriamfetol (JZP-110) is a selective dopamine and norepinephrine reuptake inhibitor with wake-promoting effects. This phase 3 study (NCT02348593) evaluated the safety and efficacy of solriamfetol in narcolepsy. METHODS: Patients with narcolepsy wi …
OBJECTIVE: Solriamfetol (JZP-110) is a selective dopamine and norepinephrine reuptake inhibitor with wake-promoting effects. This phase 3 …
Narcolepsy.
Kornum BR, Knudsen S, Ollila HM, Pizza F, Jennum PJ, Dauvilliers Y, Overeem S. Kornum BR, et al. Nat Rev Dis Primers. 2017 Feb 9;3:16100. doi: 10.1038/nrdp.2016.100. Nat Rev Dis Primers. 2017. PMID: 28179647 Review.
Two subtypes of narcolepsy have been described (narcolepsy type 1 and narcolepsy type 2), both of which have similar clinical profiles, except for the presence of cataplexy, which occurs only in patients with narcolepsy type 1. ...However, direc …
Two subtypes of narcolepsy have been described (narcolepsy type 1 and narcolepsy type 2), both of which have similar …
Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.
Howell M, Avidan AY, Foldvary-Schaefer N, Malkani RG, During EH, Roland JP, McCarter SJ, Zak RS, Carandang G, Kazmi U, Ramar K. Howell M, et al. J Clin Sleep Med. 2023 Apr 1;19(4):759-768. doi: 10.5664/jcsm.10424. J Clin Sleep Med. 2023. PMID: 36515157 Free PMC article. Review.
INTRODUCTION: This guideline establishes clinical practice recommendations for the management of rapid eye movement sleep behavior disorder (RBD) in adults. ...Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideli …
INTRODUCTION: This guideline establishes clinical practice recommendations for the management of rapid eye movement sleep behavior di …
Narcolepsy.
Mitler MM, Hajdukovic R, Erman M, Koziol JA. Mitler MM, et al. J Clin Neurophysiol. 1990 Jan;7(1):93-118. doi: 10.1097/00004691-199001000-00008. J Clin Neurophysiol. 1990. PMID: 1968069 Free PMC article.
Narcolepsy is a neurological condition with a prevalence of up to 1 per 1,000 that is characterized by irresistible bouts of sleep. ...The condition is strongly associated with the HLA-DR2 and DQw1 phenotype. The phenomenology of narcolepsy is discussed, and diagnos …
Narcolepsy is a neurological condition with a prevalence of up to 1 per 1,000 that is characterized by irresistible bouts of sleep. . …
Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1.
Dauvilliers Y, Mignot E, Del Río Villegas R, Du Y, Hanson E, Inoue Y, Kadali H, Koundourakis E, Meyer S, Rogers R, Scammell TE, Sheikh SI, Swick T, Szakács Z, von Rosenstiel P, Wu J, Zeitz H, Murthy NV, Plazzi G, von Hehn C. Dauvilliers Y, et al. N Engl J Med. 2023 Jul 27;389(4):309-321. doi: 10.1056/NEJMoa2301940. N Engl J Med. 2023. PMID: 37494485 Clinical Trial.
METHODS: We conducted a phase 2, randomized, placebo-controlled trial of TAK-994, an oral orexin receptor 2-selective agonist, in patients with narcolepsy type 1. Patients with confirmed narcolepsy type 1 according to clinical criteria were r …
METHODS: We conducted a phase 2, randomized, placebo-controlled trial of TAK-994, an oral orexin receptor 2-selective agonist, …
Once-nightly sodium oxybate (FT218) demonstrated improvement of symptoms in a phase 3 randomized clinical trial in patients with narcolepsy.
Kushida CA, Shapiro CM, Roth T, Thorpy MJ, Corser BC, Ajayi AO, Rosenberg R, Roy A, Seiden D, Dubow J, Dauvilliers Y. Kushida CA, et al. Sleep. 2022 Jun 13;45(6):zsab200. doi: 10.1093/sleep/zsab200. Sleep. 2022. PMID: 34358324 Free PMC article. Clinical Trial.
STUDY OBJECTIVES: To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST-ON trial. METHODS: Narcolepsy patients aged 16 years were randomized 1:1 t …
STUDY OBJECTIVES: To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with …
524 results