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Page 1
Statins Neuromuscular Adverse Effects.
Attardo S, Musumeci O, Velardo D, Toscano A. Attardo S, et al. Int J Mol Sci. 2022 Jul 28;23(15):8364. doi: 10.3390/ijms23158364. Int J Mol Sci. 2022. PMID: 35955495 Free PMC article. Review.
Muscle-related adverse events include cramps, myalgia, weakness, immune-mediated necrotizing myopathy and, more rarely, rhabdomyolysis. Moreover, they may lead to peripheral neuropathy and induce or unmask a preexisting neuromuscular junction dysfunction. ...On this …
Muscle-related adverse events include cramps, myalgia, weakness, immune-mediated necrotizing myopathy and, more rarely, rhabdo …
Clinical pearls and promising therapies in myositis.
Connolly CM, Paik JJ. Connolly CM, et al. Expert Rev Clin Immunol. 2023 Jul-Dec;19(7):797-811. doi: 10.1080/1744666X.2023.2212162. Epub 2023 May 18. Expert Rev Clin Immunol. 2023. PMID: 37158055 Review.
However, advances utilizing myositis-specific autoantibodies have facilitated the definition of subgroups as well as the prediction of clinical phenotypes, disease course, and response to treatment. AREAS COVERED: Herein we provide an overview of the clinical presentations …
However, advances utilizing myositis-specific autoantibodies have facilitated the definition of subgroups as well as the prediction o …
Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge.
Merlonghi G, Antonini G, Garibaldi M. Merlonghi G, et al. Autoimmun Rev. 2022 Feb;21(2):102993. doi: 10.1016/j.autrev.2021.102993. Epub 2021 Nov 16. Autoimmun Rev. 2022. PMID: 34798316 Review.
Low fibre size variability with overexpression of both MHC-I and II, associated with C5b-9 deposition, could could be observed in CIM, while increased connective tissue should lead to consider MD, or TM in absence of C5b-9 deposition. ...
Low fibre size variability with overexpression of both MHC-I and II, associated with C5b-9 deposition, could could be observed in CIM …
Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies.
Mariampillai K, Granger B, Amelin D, Guiguet M, Hachulla E, Maurier F, Meyer A, Tohmé A, Charuel JL, Musset L, Allenbach Y, Benveniste O. Mariampillai K, et al. JAMA Neurol. 2018 Dec 1;75(12):1528-1537. doi: 10.1001/jamaneurol.2018.2598. JAMA Neurol. 2018. PMID: 30208379 Free PMC article.
Cluster 2 (n = 91) regrouped patients who were women and had high creatine phosphokinase levels, necrosis without inflammation, and anti-SRP or anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies corresponding to immune-mediated necrotizing myopathy …
Cluster 2 (n = 91) regrouped patients who were women and had high creatine phosphokinase levels, necrosis without inflammation, and anti-SRP …
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK. Satoh M, et al. Clin Rev Allergy Immunol. 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. Clin Rev Allergy Immunol. 2017. PMID: 26424665 Free PMC article. Review.
Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain clinical manifestations. Classic MSAs known for over 30 years include antibodies to Jo-1 (histidyl transfer RNA (tRNA) synthetase) and other am …
Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain cli …
Acquired necrotizing myopathies.
Allenbach Y, Benveniste O. Allenbach Y, et al. Curr Opin Neurol. 2013 Oct;26(5):554-60. doi: 10.1097/WCO.0b013e328364e9d9. Curr Opin Neurol. 2013. PMID: 23995277 Review.
PURPOSE OF REVIEW: Necrotizing myopathy exhibits a specific histological pattern, characterized by significant necrosis, with simultaneous muscle fiber regeneration, but without or with little inflammation. This histological pattern may be observed in acquire …
PURPOSE OF REVIEW: Necrotizing myopathy exhibits a specific histological pattern, characterized by significant necrosis, with …
Anti-HMGCR myopathy: clinical and histopathological features, and prognosis.
Kurashige T. Kurashige T. Curr Opin Rheumatol. 2021 Nov 1;33(6):554-562. doi: 10.1097/BOR.0000000000000832. Curr Opin Rheumatol. 2021. PMID: 34456255 Review.
PURPOSE OF REVIEW: This review aims to describe clinical and pathological features, prognosis and treatment in patients with anti-HMGCR antibody positive immune-mediated necrotizing myopathy (HMGCR-IMNM) based on recent findings. RECENT FINDINGS: Using advances in d …
PURPOSE OF REVIEW: This review aims to describe clinical and pathological features, prognosis and treatment in patients with anti-HMGCR anti …
Idiopathic inflammatory myopathies.
Dimachkie MM, Barohn RJ. Dimachkie MM, et al. Front Neurol Neurosci. 2009;26:126-146. doi: 10.1159/000212374. Epub 2009 Apr 6. Front Neurol Neurosci. 2009. PMID: 19349710 Review.
IBM is refractory to corticosteroids and intravenous gamma globulins. This clinical observation and the pathologic features support the hypothesis that IBM is a muscle-degenerative disease. Most recently, a fourth inflammatory myopathy subtype called necrotizing …
IBM is refractory to corticosteroids and intravenous gamma globulins. This clinical observation and the pathologic features support t …
Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies.
Vidal J, Fernandez EA, Wohlwend M, Laurila PP, Lopez-Mejia A, Ochala J, Lobrinus AJ, Kayser B, Lopez-Mejia IC, Place N, Zanou N. Vidal J, et al. J Cachexia Sarcopenia Muscle. 2023 Dec;14(6):2882-2897. doi: 10.1002/jcsm.13349. Epub 2023 Nov 15. J Cachexia Sarcopenia Muscle. 2023. PMID: 37964752 Free PMC article.

RESULTS: RYR1 transcripts were reduced in muscle samples of patients suffering from necrotizing myopathy (P = 0.026), inclusion body myopathy (P = 0.003), polymyositis (P < 0.001) and juvenile dermatomyositis (P < 0.001) and in muscle samples of myotonic dystr

…
RESULTS: RYR1 transcripts were reduced in muscle samples of patients suffering from necrotizing myopathy (P = 0.026), inclusio …
Autoimmune Myopathies: Updates on Evaluation and Treatment.
McGrath ER, Doughty CT, Amato AA. McGrath ER, et al. Neurotherapeutics. 2018 Oct;15(4):976-994. doi: 10.1007/s13311-018-00676-2. Neurotherapeutics. 2018. PMID: 30341597 Free PMC article. Review.
The major forms of autoimmune myopathies include dermatomyositis (DM), polymyositis (PM), myositis associated with antisynthetase syndrome (ASS), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM). While each of these conditions has uniqu …
The major forms of autoimmune myopathies include dermatomyositis (DM), polymyositis (PM), myositis associated with antisynthetase syndrome ( …
100 results