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Idiopathic inflammatory myopathies.
Lundberg IE, Fujimoto M, Vencovsky J, Aggarwal R, Holmqvist M, Christopher-Stine L, Mammen AL, Miller FW. Lundberg IE, et al. Nat Rev Dis Primers. 2021 Dec 2;7(1):86. doi: 10.1038/s41572-021-00321-x. Nat Rev Dis Primers. 2021. PMID: 34857798 Review.
Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous group of autoimmune disorders with varying clinical manifestations, treatment responses and prognoses. Muscle weakness is usually the classical clinical manifestation but other organs can …
Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous group of autoimmune disorders with varying clinical ma …
Current Classification and Management of Inflammatory Myopathies.
Schmidt J. Schmidt J. J Neuromuscul Dis. 2018;5(2):109-129. doi: 10.3233/JND-180308. J Neuromuscul Dis. 2018. PMID: 29865091 Free PMC article. Review.
Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progressive, chronic disease course in IBM, patients with myositis typically present with a subacute onset of weakness of arms and legs, oft …
Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progres …
Statins Neuromuscular Adverse Effects.
Attardo S, Musumeci O, Velardo D, Toscano A. Attardo S, et al. Int J Mol Sci. 2022 Jul 28;23(15):8364. doi: 10.3390/ijms23158364. Int J Mol Sci. 2022. PMID: 35955495 Free PMC article. Review.
On this purpose, it is expected that pharmacogenomic and environmental studies will help to timely predict neuromuscular complications due to statin exposure, leading to a more personalized therapeutic approach....
On this purpose, it is expected that pharmacogenomic and environmental studies will help to timely predict neuromuscular complication …
Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies.
Mariampillai K, Granger B, Amelin D, Guiguet M, Hachulla E, Maurier F, Meyer A, Tohmé A, Charuel JL, Musset L, Allenbach Y, Benveniste O. Mariampillai K, et al. JAMA Neurol. 2018 Dec 1;75(12):1528-1537. doi: 10.1001/jamaneurol.2018.2598. JAMA Neurol. 2018. PMID: 30208379 Free PMC article.
IMPORTANCE: Idiopathic inflammatory myopathies are heterogeneous in their pathophysiologic features and prognosis. The emergence of myositis-specific autoantibodies suggests that subgroups of patients exist. ...
IMPORTANCE: Idiopathic inflammatory myopathies are heterogeneous in their pathophysiologic features and prognosis. The emergence of m …
Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts.
Ma X, Bu BT. Ma X, et al. Front Immunol. 2022 Oct 13;13:1019972. doi: 10.3389/fimmu.2022.1019972. eCollection 2022. Front Immunol. 2022. PMID: 36311711 Free PMC article. Review.
PURPOSE OF REVIEW: This review aims to describe clinical and histological features, treatment, and prognosis in patients with anti-signal recognition particle (SRP) autoantibodies positive immune-mediated necrotizing myopathy (SRP-IMNM) based on previous findings. ...
PURPOSE OF REVIEW: This review aims to describe clinical and histological features, treatment, and prognosis in patients with anti-si …
Clinical pearls and promising therapies in myositis.
Connolly CM, Paik JJ. Connolly CM, et al. Expert Rev Clin Immunol. 2023 Jul-Dec;19(7):797-811. doi: 10.1080/1744666X.2023.2212162. Epub 2023 May 18. Expert Rev Clin Immunol. 2023. PMID: 37158055 Review.
INTRODUCTION: Idiopathic inflammatory myopathies (IIMs) represent a diverse group of systemic autoimmune disorders with variable clinical manifestations and disease course. Currently, the challenges of IIMs are multifold, including difficulties in timely diagnosis owing to …
INTRODUCTION: Idiopathic inflammatory myopathies (IIMs) represent a diverse group of systemic autoimmune disorders with variable clinical ma …
Diagnosis and classification of idiopathic inflammatory myopathies.
Lundberg IE, Miller FW, Tjärnlund A, Bottai M. Lundberg IE, et al. J Intern Med. 2016 Jul;280(1):39-51. doi: 10.1111/joim.12524. J Intern Med. 2016. PMID: 27320359 Free PMC article. Review.
Another cornerstone in the diagnostic procedure is muscle biopsy to identify inflammation and to exclude noninflammatory myopathies. Treatment effect and prognosis vary by subgroup. To develop new and better therapies, validated classification criteria that identify distin …
Another cornerstone in the diagnostic procedure is muscle biopsy to identify inflammation and to exclude noninflammatory myopathies. Treatme …
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK. Satoh M, et al. Clin Rev Allergy Immunol. 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. Clin Rev Allergy Immunol. 2017. PMID: 26424665 Free PMC article. Review.
Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain clinical manifestations. Classic MSAs known for over 30 years include antibodies to Jo-1 (histidyl transfer RNA (tRNA) synthetase) and other am …
Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain cli …
Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays.
Damoiseaux J, Vulsteke JB, Tseng CW, Platteel ACM, Piette Y, Shovman O, Bonroy C, Hamann D, De Langhe E, Musset L, Chen YH, Shoenfeld Y, Allenbach Y, Bossuyt X. Damoiseaux J, et al. Autoimmun Rev. 2019 Mar;18(3):293-305. doi: 10.1016/j.autrev.2018.10.004. Epub 2019 Jan 11. Autoimmun Rev. 2019. PMID: 30639643 Free article. Review.
Myositis-specific autoantibodies (MSA) are increasingly recognized as valuable tools for diagnosis, classification and prognosis of IIM. For example, ASS is associated with anti-aminoacyl tRNA synthetase antibodies (anti-Jo-1, PL-7, PL-12, ), IMNM with anti-SRP and anti-HM …
Myositis-specific autoantibodies (MSA) are increasingly recognized as valuable tools for diagnosis, classification and prognosis of I …
110 results