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Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's disease in rats.
Dubey H, Dubey A, Gulati K, Ray A. Dubey H, et al. J Physiol Pharmacol. 2022 Feb;73(1). doi: 10.26402/jpp.2022.1.01. Epub 2022 May 27. J Physiol Pharmacol. 2022. PMID: 35639033 Free article.
Alzheimer's disease (AD) has been closely linked to type 2 diabetes mellitus (T2DM) and insulin resistance plays a key role in the onset and development of AD. ...The present study evaluated the effects NOS substrate, L-arginine and NOS-blocker, NG-nitro-L …
Alzheimer's disease (AD) has been closely linked to type 2 diabetes mellitus (T2DM) and insulin resistance plays a key role in …
Modulation of learning and memory by natural polyamines.
Guerra GP, Rubin MA, Mello CF. Guerra GP, et al. Pharmacol Res. 2016 Oct;112:99-118. doi: 10.1016/j.phrs.2016.03.023. Epub 2016 Mar 22. Pharmacol Res. 2016. PMID: 27015893 Free article. Review.
The interaction with the opioid system, the facilitation and disruption of morphine-induced reward and the effect of polyamines and putative polyamine antagonists on animal models of cognitive diseases, such as Alzheimer's, Huntington, acute neuroinflammation and br …
The interaction with the opioid system, the facilitation and disruption of morphine-induced reward and the effect of polyamines and putative …
Arbutin attenuates monosodium L-glutamate induced neurotoxicity and cognitive dysfunction in rats.
Kumar M, Kumar A, Sindhu RK, Kushwah AS. Kumar M, et al. Neurochem Int. 2021 Dec;151:105217. doi: 10.1016/j.neuint.2021.105217. Epub 2021 Oct 25. Neurochem Int. 2021. PMID: 34710534
Recently, arbutin showed benefits in animal models of epilepsy, Parkinson's disease, and Alzheimer's disease that further expanded its therapeutic potential against brain disorders. ...Histopathological findings in hippocampus and cortex revealed neuroprotective out …
Recently, arbutin showed benefits in animal models of epilepsy, Parkinson's disease, and Alzheimer's disease that further expa …
Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model.
Nakamura N, Ushida T, Onoda A, Ueda K, Miura R, Suzuki T, Katsuki S, Mizutani H, Yoshida K, Tano S, Iitani Y, Imai K, Hayakawa M, Kajiyama H, Sato Y, Kotani T. Nakamura N, et al. Front Pediatr. 2023 Jul 13;11:1168173. doi: 10.3389/fped.2023.1168173. eCollection 2023. Front Pediatr. 2023. PMID: 37520045 Free PMC article.
INTRODUCTION: To investigate the mechanism underlying the increased risk of subsequent neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated the neurodevelopment of offspring of a preeclampsia rat model induced by the administration of N-nitr …
INTRODUCTION: To investigate the mechanism underlying the increased risk of subsequent neurodevelopmental disorders in children born to moth …
Ellagic acid prevents dementia through modulation of PI3-kinase-endothelial nitric oxide synthase signalling in streptozotocin-treated rats.
Kumar M, Bansal N. Kumar M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2018 Sep;391(9):987-1001. doi: 10.1007/s00210-018-1524-2. Epub 2018 Jun 15. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29947909
Previously, we reported that chronic administration of EGA prevented the impairment of cognitive abilities in rats using the intracerebroventricular-administered streptozotocin (STZ-ICV) model of Alzheimer's disease. Impairment of phosphoinositide 3 (PI3)-kinase-reg …
Previously, we reported that chronic administration of EGA prevented the impairment of cognitive abilities in rats using the intracerebroven …
Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.
Santhanam AV, d'Uscio LV, He T, Das P, Younkin SG, Katusic ZS. Santhanam AV, et al. J Neurochem. 2015 Sep;134(6):1129-38. doi: 10.1111/jnc.13205. Epub 2015 Jul 15. J Neurochem. 2015. PMID: 26111938 Free PMC article.

Moreover, superoxide anion production was increased in cerebral microvessels of Tg2576 mice (p < 0.05). Incubation with NOS inhibitor, Nomega-nitro-L-arginine methyl ester, decreased superoxide anion indicating that uncoupled eNOS is most lik

…

Moreover, superoxide anion production was increased in cerebral microvessels of Tg2576 mice (p < 0.05). Incubation with NOS inhibitor, No

…
Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats.
Zhang L, Zheng H, Luo J, Li L, Pan X, Jiang T, Xiao C, Pei Z, Hu X. Zhang L, et al. Hypertens Res. 2018 Jun;41(6):414-425. doi: 10.1038/s41440-018-0033-5. Epub 2018 Mar 22. Hypertens Res. 2018. PMID: 29568075
In this study, we investigated the role of eNOS in Abeta deposition and cognitive function in stroke-prone spontaneously hypertensive (SHRSP) rats. Physical exercise was used as a promoter, and N(omega)-nitro L-arginine methyl ester (L-NAME) was …
In this study, we investigated the role of eNOS in Abeta deposition and cognitive function in stroke-prone spontaneously hypertensive (SHRSP …
Modulation of the Nitrergic Pathway via Activation of PPAR-γ Contributes to the Neuroprotective Effect of Pioglitazone Against Streptozotocin-Induced Memory Dysfunction.
Prakash A, Kumar A, Ming LC, Mani V, Majeed AB. Prakash A, et al. J Mol Neurosci. 2015 Jul;56(3):739-50. doi: 10.1007/s12031-015-0508-7. Epub 2015 Feb 18. J Mol Neurosci. 2015. PMID: 25854775
Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired memory function and oxidative damage. ...Then rats were treated with pioglitazone, NO modulators [L-arginine and nitro-L-arginine methyl ester (L-NAM …
Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired memory function and oxidative damage. ...The …
Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease.
Casamenti F, Prosperi C, Scali C, Giovannelli L, Colivicchi MA, Faussone-Pellegrini MS, Pepeu G. Casamenti F, et al. Neuroscience. 1999;91(3):831-42. doi: 10.1016/s0306-4522(98)00680-0. Neuroscience. 1999. PMID: 10391466
Inhibition of inducible nitric oxide synthase expression by N(G)-nitro-L-arginine methyl ester administration prevented the increase in nitrogen intermediates and GABA release, but not in glutamate release. ...
Inhibition of inducible nitric oxide synthase expression by N(G)-nitro-L-arginine methyl ester administra …
Involvement of the nitric oxide signaling in modulation of naringin against intranasal manganese and intracerbroventricular β-amyloid induced neurotoxicity in rats.
Kaur G, Prakash A. Kaur G, et al. J Nutr Biochem. 2020 Feb;76:108255. doi: 10.1016/j.jnutbio.2019.108255. Epub 2019 Oct 23. J Nutr Biochem. 2020. PMID: 31759198
Manganese -induced aggregation of the amyloid-beta peptide (Abeta) is a hallmark molecular feature of Alzheimer's disease (AD). The current study was designed to investigate the effects of chronic administration of naringin against beta-A(1-42) and manganese induced …
Manganese -induced aggregation of the amyloid-beta peptide (Abeta) is a hallmark molecular feature of Alzheimer's disease (AD) …
Role of Noradrenergic Brain Nuclei in the Regulation of Carotid Artery Blood Flow: Pharmacological Evidence from Anesthetized Pigs with Alpha-2 Adrenergic Receptor Modulator Drugs.
Wirth KJ. Wirth KJ. J Alzheimers Dis. 2018;66(1):407-419. doi: 10.3233/JAD-180340. J Alzheimers Dis. 2018. PMID: 30248055
BACKGROUND: Cerebral hypoperfusion and degeneration of the noradrenergic locus coeruleus (LC) occur early in Alzheimer's disease (AD). Cerebral blood vessels are densely innervated by noradrenergic projections from the LC suggesting a functional role for the regulat …
BACKGROUND: Cerebral hypoperfusion and degeneration of the noradrenergic locus coeruleus (LC) occur early in Alzheimer's disea …
Chromogranin A triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells.
Taupenot L, Ciesielski-Treska J, Ulrich G, Chasserot-Golaz S, Aunis D, Bader MF. Taupenot L, et al. Neuroscience. 1996 May;72(2):377-89. doi: 10.1016/0306-4522(96)83172-1. Neuroscience. 1996. PMID: 8737408
In human brain, chromogranin A is a common feature of regions that are known to be affected by various neurodegenerative pathologies such as Alzheimer's, Parkinson's and Pick's diseases. Brain degenerative areas are generally infiltrated by activated microglial cell …
In human brain, chromogranin A is a common feature of regions that are known to be affected by various neurodegenerative pathologies such as …
Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice.
Allami N, Javadi-Paydar M, Rayatnia F, Sehhat K, Rahimian R, Norouzi A, Dehpour AR. Allami N, et al. Eur J Pharmacol. 2011 Jan 10;650(1):240-8. doi: 10.1016/j.ejphar.2010.10.007. Epub 2010 Oct 14. Eur J Pharmacol. 2011. PMID: 20951129
Pioglitazone, an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), which is widely used in treatment of type 2 diabetes, has shown some therapeutic effect in Alzheimer's disease. In this study, effects of acute pioglitazone on acquisition, con …
Pioglitazone, an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), which is widely used in treatment of type 2 diabet …
Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes.
de la Torre JC, Aliev G. de la Torre JC, et al. J Cereb Blood Flow Metab. 2005 Jun;25(6):663-72. doi: 10.1038/sj.jcbfm.9600057. J Cereb Blood Flow Metab. 2005. PMID: 15703700
The neuronal and endothelial (nNOS/eNOS) constitutive inhibitor nitro-L-arginine methyl ester (L-NAME) 20 mg/kg was administered after 26 weeks for 3 days to 2-VO and S-VO groups and spatial memory was assessed with a modified Morris watermaze t …
The neuronal and endothelial (nNOS/eNOS) constitutive inhibitor nitro-L-arginine methyl ester (L-NAME) 20 …
Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.
Nakajima M, Shirasawa T. Nakajima M, et al. Neuroscience. 2004;125(3):563-8. doi: 10.1016/j.neuroscience.2004.01.016. Neuroscience. 2004. PMID: 15099670
Presenilin-1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. To probe the functions of PS1 on neuronal resistance to oxidative stress, we pharmacologically examined the death signals in PS1-deficient neurons induced by …
Presenilin-1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. To probe the funct …