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Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study.
Fattizzo B, Gurnari C, Cassanello G, Bortolotti M, Awada H, Giammarco S, Consonni D, Sica S, Gandhi S, Trikha R, Large J, Salter S, Maciejewski JP, Barcellini W, Kulasekararaj AG. Fattizzo B, et al. Leukemia. 2023 Dec;37(12):2479-2485. doi: 10.1038/s41375-023-02047-z. Epub 2023 Oct 4. Leukemia. 2023. PMID: 37794100 Free PMC article.
Non-severe aplastic anemia is a rare bone marrow failure disorder characterized by variable degrees and combination of cytopenias, with limited data on management and outcome. ...The majority required treatment with cyclosporine (CyA) alone (N = 84) or …
Non-severe aplastic anemia is a rare bone marrow failure disorder characterized by variable degrees and combinat …
Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre.
Shen Y, Li Y, Liu Q, Liu W, Yu Q, Hu H, Liu S, Dong J, Xu M, Hong Y, Chen Y, Deng S, Zhuang H, Hu Z, Lin S, Shen Y, Shen J, Zhou Y, Ye B, Wu D. Shen Y, et al. Ann Med. 2023;55(2):2271475. doi: 10.1080/07853890.2023.2271475. Epub 2023 Oct 23. Ann Med. 2023. PMID: 37871262 Free PMC article.
OBJECTIVES: The selection and timing of anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) or allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with transfusion-dependent non-severe aplastic anemia (TD-NSAA) po …
OBJECTIVES: The selection and timing of anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) or allogeneic hematopoietic stem …
Interferon-gamma and perforin-positive T cells in acquired aplastic anemia: implication in therapeutic response.
Sharma V, Kumar P, Kumar R, Chakraborty S, Namdeo M, Sazawal S, Kanga U, Seth T, Mitra DK. Sharma V, et al. Clin Exp Immunol. 2022 May 12;207(3):272-278. doi: 10.1093/cei/uxab006. Clin Exp Immunol. 2022. PMID: 35553631 Free PMC article.
The percentage of these cells was also increased in untreated severe and very severe aplastic anemia when compared with non-severe aplastic anemia patients. In patients before and after IST the median percentage of T cells producing IFN-gamma and perfo …
The percentage of these cells was also increased in untreated severe and very severe aplastic anemia when compared with non-severe …
Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Ruan J, Yang C, Du Y, Chen M, Han B. Ruan J, et al. Clin Exp Med. 2023 Jul;23(3):767-776. doi: 10.1007/s10238-022-00826-z. Epub 2022 Apr 21. Clin Exp Med. 2023. PMID: 35445952
We assumed that the serum lipid metabolites could also help the diagnosis and prognostic prediction of aplastic anemia (AA). In this study, serum lipid profiles were explored in AA patients before and after cyclosporin (CsA) treatment. Meanwhile, hypocellular myelodysplast …
We assumed that the serum lipid metabolites could also help the diagnosis and prognostic prediction of aplastic anemia (AA). In this …
Natural history of transfusion-independent non-severe aplastic anemia in children.
Nishio N, Yagasaki H, Takahashi Y, Muramatsu H, Hama A, Yoshida N, Kudo K, Kojima S. Nishio N, et al. Int J Hematol. 2009 May;89(4):409-413. doi: 10.1007/s12185-009-0302-9. Epub 2009 Apr 3. Int J Hematol. 2009. PMID: 19343478
Although the known clinical courses of non-severe aplastic anemia (NSAA) in children comprise spontaneous resolution, persistent NSAA, or progression to severe aplastic anemia (SAA), only a few published reports have indicated the outcome of transfusio …
Although the known clinical courses of non-severe aplastic anemia (NSAA) in children comprise spontaneous resolu …
Interleukin-6 and Interleukin-8 Levels Correlate With the Severity of Aplastic Anemia in Children.
Gupta V, Kumar S, Sonowal R, Singh SK. Gupta V, et al. J Pediatr Hematol Oncol. 2017 Apr;39(3):214-216. doi: 10.1097/MPH.0000000000000724. J Pediatr Hematol Oncol. 2017. PMID: 28060106
Levels were the highest in patients with very severe aplastic anemia (724.33519.42), followed by severe aplastic anemia (80.5166.28 pg/mL), and non-severe aplastic anemia (6.011.89). Differences were statistically significant. A similar trend was also …
Levels were the highest in patients with very severe aplastic anemia (724.33519.42), followed by severe aplastic anemia (80.5166.28 pg/mL), …
Efficacy of glycyrrhizin combined with cyclosporine in the treatment of non-severe aplastic anemia.
Ren CA, Li YX, Cui JY, Sheng ZX, Ran XH, Wang BH, Zhang MH. Ren CA, et al. Chin Med J (Engl). 2013;126(11):2083-6. Chin Med J (Engl). 2013. PMID: 23769562 Clinical Trial.
Glycyrrhizin has long been used in China in the treatment of various liver diseases to lower transaminases. In this study, we observed the efficacy and safety of glycyrrhizic acid combined with CsA in the treatment of newly diagnosed patients with non-severe AA (NSAA). ...
Glycyrrhizin has long been used in China in the treatment of various liver diseases to lower transaminases. In this study, we observed …
Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
Wang J, Sun F, Sun W, Shi H, Yong Y, Liu S, Liu L. Wang J, et al. J Tradit Chin Med. 2014 Feb;34(1):23-9. doi: 10.1016/s0254-6272(14)60049-2. J Tradit Chin Med. 2014. PMID: 25102686 Free article. Clinical Trial.
OBJECTIVE: To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia (NSAA) and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. ...CONCLUSION …
OBJECTIVE: To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia (NSAA …
Effect of androgen therapy and anemia on serum erythropoietin levels in patients with aplastic anemia and myelodysplastic syndromes.
Piedras J, Hernández G, López-Karpovitch X. Piedras J, et al. Am J Hematol. 1998 Feb;57(2):113-8. doi: 10.1002/(sici)1096-8652(199802)57:2<113::aid-ajh4>3.0.co;2-z. Am J Hematol. 1998. PMID: 9462542 Free article.
Immunoreactive serum erythropoietin (EPO) was measured in anemic and non-anemic patients with acquired non-severe aplastic anemia (AA; n = 22) and myelodysplastic syndromes (MDS; n = 31) receiving or not androgens to examine the effect of androgen ther …
Immunoreactive serum erythropoietin (EPO) was measured in anemic and non-anemic patients with acquired non-severe aplastic …