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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1995 8
1996 2
1997 9
1998 4
1999 4
2000 3
2001 2
2002 5
2003 1
2004 2
2005 4
2006 5
2007 3
2008 2
2011 1
2012 2
2014 1
2022 1
2024 0

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59 results

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Page 1
Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
Chao EC, Velasquez JL, Witherspoon MS, Rozek LS, Peel D, Ng P, Gruber SB, Watson P, Rennert G, Anton-Culver H, Lynch H, Lipkin SM. Chao EC, et al. Hum Mutat. 2008 Jun;29(6):852-60. doi: 10.1002/humu.20735. Hum Mutat. 2008. PMID: 18383312 Free article.
Lynch syndrome, also known as hereditary nonpolyposis colon cancer (HNPCC), is the most common known genetic syndrome for colorectal cancer (CRC). ...MAPP-MMR significantly outperformed other missense variant classification algorithms (sensitivity, 94%; speci …
Lynch syndrome, also known as hereditary nonpolyposis colon cancer (HNPCC), is the most common known genetic syndrome f …
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee. Trimble CL, et al. Obstet Gynecol. 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. Obstet Gynecol. 2012. PMID: 23090535 Free PMC article. Review.
We reviewed studies pertaining to the diagnostic challenges of endometrial precancers, their predictive value, and evidence to support management strategies. Currently, two diagnostic schemas are in use: the four-class 1994 World Health Organization hyperplasia system, bas …
We reviewed studies pertaining to the diagnostic challenges of endometrial precancers, their predictive value, and evidence to suppor …
Molecular basis of endometrial cancer.
Berchuck A, Boyd J. Berchuck A, et al. Cancer. 1995 Nov 15;76(10 Suppl):2034-40. doi: 10.1002/1097-0142(19951115)76:10+<2034::aid-cncr2820761321>3.0.co;2-u. Cancer. 1995. PMID: 8634996 Review.
Mutations in the K-ras oncogene occur in 10% and in 20-30% of American and Japanese endometrial cancers, respectively. K-ras mutations also have been observed in endometrial hyperplasias, and this may represent an early event in the development of some cancers. ...Recent s …
Mutations in the K-ras oncogene occur in 10% and in 20-30% of American and Japanese endometrial cancers, respectively. K-ras mutations also …
Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation.
Vietri MT, D'Elia G, Caliendo G, Albanese L, Signoriello G, Napoli C, Molinari AM. Vietri MT, et al. Genes (Basel). 2022 Feb 9;13(2):321. doi: 10.3390/genes13020321. Genes (Basel). 2022. PMID: 35205366 Free PMC article.
In FAP family, we found a pathogenic mutation in APC gene in 1/3 families. We observed an early onset of PDAC and a lower survival in PDAC patients belonging to mutated families, while no evidence of possible pancreatic cancer cluster regions was found. ...
In FAP family, we found a pathogenic mutation in APC gene in 1/3 families. We observed an early onset of PDAC and a lower survival in …
Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. Cancer Genetics Studies Consortium.
Burke W, Petersen G, Lynch P, Botkin J, Daly M, Garber J, Kahn MJ, McTiernan A, Offit K, Thomson E, Varricchio C. Burke W, et al. JAMA. 1997 Mar 19;277(11):915-9. JAMA. 1997. PMID: 9062331 Review.
OBJECTIVE: To provide recommendations for cancer surveillance and risk reduction for individuals carrying mutations associated with hereditary nonpolyposis colon cancer (HNPCC). PARTICIPANTS: A task force with expertise in medical genetics, oncology, primary …
OBJECTIVE: To provide recommendations for cancer surveillance and risk reduction for individuals carrying mutations associated with heredita …
DNA repair and tumorigenesis: lessons from hereditary cancer syndromes.
Heinen CD, Schmutte C, Fishel R. Heinen CD, et al. Cancer Biol Ther. 2002 Sep-Oct;1(5):477-85. doi: 10.4161/cbt.1.5.160. Cancer Biol Ther. 2002. PMID: 12496472 Review.
The discovery that alterations of the DNA mismatch repair system (MMR) were linked to the common human cancer susceptibility syndrome hereditary nonpolyposis colon cancer (HNPCC) resulted in the declaration of a third class of genes involved in tumor developm …
The discovery that alterations of the DNA mismatch repair system (MMR) were linked to the common human cancer susceptibility syndrome heredi …
Aspirin in gastrointestinal oncology: new data on an old friend.
Langley RE, Rothwell PM. Langley RE, et al. Curr Opin Oncol. 2014 Jul;26(4):441-7. doi: 10.1097/CCO.0000000000000098. Curr Opin Oncol. 2014. PMID: 24840525 Review.
Reduction in distant metastasis and improvements in cancer outcomes appear within 5 years of randomization indicating that aspirin affects tumour growth or the development and spread of metastases from existing cancers or both. In Lynch syndrome (hereditary nonpolyposis …
Reduction in distant metastasis and improvements in cancer outcomes appear within 5 years of randomization indicating that aspirin affects t …
Abnormalities of lectin histochemistry in familial polyposis coli and hereditary nonpolyposis colorectal cancer.
Sams JS, Lynch HT, Burt RW, Lanspa SJ, Boland CR. Sams JS, et al. Cancer. 1990 Aug 1;66(3):502-8. doi: 10.1002/1097-0142(19900801)66:3<502::aid-cncr2820660317>3.0.co;2-n. Cancer. 1990. PMID: 2194645 Review.
Using a technique for quantitating lectin binding on the tissue sections that provided a score from 0 to 400, labeling with certain lectins was found to vary slightly as a function of age and sex. ...Of interest, staining of the tissues by peanut and wheat germ lectins inc …
Using a technique for quantitating lectin binding on the tissue sections that provided a score from 0 to 400, labeling with certain l …
Psychological opportunities and hazards in predictive genetic testing for cancer risk.
Codori AM. Codori AM. Gastroenterol Clin North Am. 1997 Mar;26(1):19-39. doi: 10.1016/s0889-8553(05)70281-8. Gastroenterol Clin North Am. 1997. PMID: 9119438 Free article. Review.
This article examines the arguments and data for and against this caution, citing examples related to hereditary nonpolyposis colon cancer and drawing upon literature on testing for other genetic diseases....
This article examines the arguments and data for and against this caution, citing examples related to hereditary nonpolyposis colo …
Identification of mismatch repair genes and their role in the development of cancer.
Fishel R, Kolodner RD. Fishel R, et al. Curr Opin Genet Dev. 1995 Jun;5(3):382-95. doi: 10.1016/0959-437x(95)80055-7. Curr Opin Genet Dev. 1995. PMID: 7549435 Review.
In humans, defective mismatch repair genes have been linked to hereditary nonpolyposis colon cancer as well as to sporadic cancers that exhibit length polmorphisms in simple repeat (microsatellite) DNA sequences. The involvement of mismatch repair defects in …
In humans, defective mismatch repair genes have been linked to hereditary nonpolyposis colon cancer as well as to spora …
59 results