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Quoted phrase not found in phrase index: "Obesity due to congenital leptin deficiency"
Page 1
Leptin treatment: facts and expectations.
Paz-Filho G, Mastronardi CA, Licinio J. Paz-Filho G, et al. Metabolism. 2015 Jan;64(1):146-56. doi: 10.1016/j.metabol.2014.07.014. Epub 2014 Aug 3. Metabolism. 2015. PMID: 25156686 Free article. Review.
Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. ...Remarkable weight loss has been observed in patients with C …
Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin …
Eating behaviour in contrasting adiposity phenotypes: Monogenic obesity and congenital generalized lipodystrophy.
Santos JL, Cortés VA. Santos JL, et al. Obes Rev. 2021 Jan;22(1):e13114. doi: 10.1111/obr.13114. Epub 2020 Aug 2. Obes Rev. 2021. PMID: 33030294 Review.
Most known types of nonsyndromic monogenic obesity are caused by rare mutations in genes of the leptin-melanocortin pathway controlling appetite and adiposity. ...As a result of hypoleptinemia, patients with lipodystrophy show alterations in eating behaviour charact …
Most known types of nonsyndromic monogenic obesity are caused by rare mutations in genes of the leptin-melanocortin pathway co …
Leptin deficiency: clinical implications and opportunities for therapeutic interventions.
Blüher S, Shah S, Mantzoros CS. Blüher S, et al. J Investig Med. 2009 Oct;57(7):784-8. doi: 10.2310/JIM.0b013e3181b9163d. J Investig Med. 2009. PMID: 19730134 Free PMC article. Review.
Observational and interventional studies in humans with (complete) congenital leptin deficiency caused by mutations in the leptin gene or with relative leptin deficiency as seen in states of negative energy balance such as lipoatro …
Observational and interventional studies in humans with (complete) congenital leptin deficiency caused by mutati …
Leptin-Mediated Changes in the Human Metabolome.
Lawler K, Huang-Doran I, Sonoyama T, Collet TH, Keogh JM, Henning E, O'Rahilly S, Bottolo L, Farooqi IS. Lawler K, et al. J Clin Endocrinol Metab. 2020 Aug 1;105(8):2541-52. doi: 10.1210/clinem/dgaa251. J Clin Endocrinol Metab. 2020. PMID: 32392278 Free PMC article. Clinical Trial.
CONTEXT: While severe obesity due to congenital leptin deficiency is rare, studies in patients before and after treatment with leptin can provide unique insights into the role that leptin plays in metabolic and endocrine function. ...DESI …
CONTEXT: While severe obesity due to congenital leptin deficiency is rare, studies in patients before and after …
From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century.
Blüher M, Mantzoros CS. Blüher M, et al. Metabolism. 2015 Jan;64(1):131-45. doi: 10.1016/j.metabol.2014.10.016. Epub 2014 Oct 23. Metabolism. 2015. PMID: 25497344 Review.
This year marks the 20th anniversary of the discovery of leptin, which has tremendously stimulated translational obesity research. ...After 20 years of intense research efforts, recombinant leptin and the leptin analog metreleptin are already available …
This year marks the 20th anniversary of the discovery of leptin, which has tremendously stimulated translational obesity resea …
20 years of leptin: role of leptin in energy homeostasis in humans.
Rosenbaum M, Leibel RL. Rosenbaum M, et al. J Endocrinol. 2014 Oct;223(1):T83-96. doi: 10.1530/JOE-14-0358. Epub 2014 Jul 25. J Endocrinol. 2014. PMID: 25063755 Free PMC article. Review.
The hyperphagia, low sympathetic nervous system tone, and decreased circulating concentrations of bioactive thyroid hormones that are common to states of congenital leptin deficiency and hypoleptinemia following and during weight loss suggest that the major p …
The hyperphagia, low sympathetic nervous system tone, and decreased circulating concentrations of bioactive thyroid hormones that are common …
Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution.
Beghini M, Brandt S, Körber I, Kohlsdorf K, Vollbach H, Lennerz B, Denzer C, Shalitin S, Santini F, Blum WF, von Schnurbein J, Wabitsch M. Beghini M, et al. Int J Obes (Lond). 2021 Jul;45(7):1448-1456. doi: 10.1038/s41366-021-00809-2. Epub 2021 May 17. Int J Obes (Lond). 2021. PMID: 34002033 Free PMC article.
This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin substitution on growth factors and linear growth in children with congenital leptin deficiency (CLD). ...CONCLUSIONS: T …
This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin …
Leptin in humans: lessons from translational research.
Blüher S, Mantzoros CS. Blüher S, et al. Am J Clin Nutr. 2009 Mar;89(3):991S-997S. doi: 10.3945/ajcn.2008.26788E. Epub 2009 Jan 28. Am J Clin Nutr. 2009. PMID: 19176740 Free PMC article. Review.
Leptin has emerged over the past decade as a key hormone in not only the regulation of food intake and energy expenditure but also in the regulation of neuroendocrine and immune function as well as the modulation of glucose and fat metabolism as shown by numerous observ …
Leptin has emerged over the past decade as a key hormone in not only the regulation of food intake and energy expenditure but also in …
Leptin: a pivotal regulator of human energy homeostasis.
Farooqi IS, O'Rahilly S. Farooqi IS, et al. Am J Clin Nutr. 2009 Mar;89(3):980S-984S. doi: 10.3945/ajcn.2008.26788C. Epub 2009 Feb 11. Am J Clin Nutr. 2009. PMID: 19211814 Free article. Review.
The identification of the hormone leptin by Friedman et al (1) in 1994 has proved to be a seminal observation in biomedical science. ...In this article, we describe how the identification of humans with mutations in the gene encoding leptin and the characteri …
The identification of the hormone leptin by Friedman et al (1) in 1994 has proved to be a seminal observation in biomedical sc …
Positive effect of leptin substitution on mood and behaviour in patients with congenital leptin deficiency.
von Schnurbein J, Remy M, Brandt S, Manzoor J, Kohlsdorf K, Mahmood S, Hebebrand J, Wabitsch M. von Schnurbein J, et al. Pediatr Obes. 2023 Aug;18(8):e13057. doi: 10.1111/ijpo.13057. Epub 2023 May 24. Pediatr Obes. 2023. PMID: 37226403
This has been suggested to be mediated at least in part via reduced leptin concentrations. OBJECTIVE: We therefore aimed to ascertain if leptin substitution in patients with congenital leptin deficiency (CLD) can improve physical activity and mo …
This has been suggested to be mediated at least in part via reduced leptin concentrations. OBJECTIVE: We therefore aimed to ascertain …
28 results