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Tick-borne flaviviruses.
Lasala PR, Holbrook M. Lasala PR, et al. Clin Lab Med. 2010 Mar;30(1):221-35. doi: 10.1016/j.cll.2010.01.002. Clin Lab Med. 2010. PMID: 20513549 Review.
As our encroachment into areas of virus endemicity intensifies, and as changes in global economic and environmental conditions continue to promote the expansion of tick populations, we will undoubtedly continue to observe attendant increases in rates of disease attributabl …
As our encroachment into areas of virus endemicity intensifies, and as changes in global economic and environmental conditions continue to p …
Tick-borne flaviviruses.
Gritsun TS, Nuttall PA, Gould EA. Gritsun TS, et al. Adv Virus Res. 2003;61:317-71. doi: 10.1016/s0065-3527(03)61008-0. Adv Virus Res. 2003. PMID: 14714436 Review.
We have attempted to review the factors that influence the incidence and distribution of TBE, and to discuss possible reasons for the different clinical manifestations including most commonly observed asymptomatic infections, fever forms, acute encephalitis, and the less f …
We have attempted to review the factors that influence the incidence and distribution of TBE, and to discuss possible reasons for the differ …
Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses.
Choi Y, Kim Y. Choi Y, et al. J Infect Public Health. 2023 Dec;16(12):1933-1941. doi: 10.1016/j.jiph.2023.10.012. Epub 2023 Oct 6. J Infect Public Health. 2023. PMID: 37866271 Free article.
METHODS: Molecular diagnostic test method that qualitatively detects viruses causing viral hemorrhagic fevers hired Taq-Man Real-time RT-PCR technique. The Ct value was experimentally observed three or more times at the RNA concentration before and after the detection limi …
METHODS: Molecular diagnostic test method that qualitatively detects viruses causing viral hemorrhagic fevers hired Taq-Man Real-time RT-PCR …
Dermacentor reticulatus: a vector on the rise.
Földvári G, Široký P, Szekeres S, Majoros G, Sprong H. Földvári G, et al. Parasit Vectors. 2016 Jun 1;9(1):314. doi: 10.1186/s13071-016-1599-x. Parasit Vectors. 2016. PMID: 27251148 Free PMC article. Review.
We conclude that although great strides have been made in our knowledge of the eco-epidemiology of this species, several gaps still need to be filled with basic research, targeting possible reservoir and vector roles and the key factors resulting in the observed geographic …
We conclude that although great strides have been made in our knowledge of the eco-epidemiology of this species, several gaps still need to …
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
Flint M, McMullan LK, Dodd KA, Bird BH, Khristova ML, Nichol ST, Spiropoulou CF. Flint M, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3206-16. doi: 10.1128/AAC.02393-14. Epub 2014 Mar 24. Antimicrob Agents Chemother. 2014. PMID: 24663025 Free PMC article.
No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). We …
No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV …
Clinical evaluation of highly pathogenic tick-borne flavivirus infection in the mouse model.
Tigabu B, Juelich T, Bertrand J, Holbrook MR. Tigabu B, et al. J Med Virol. 2009 Jul;81(7):1261-9. doi: 10.1002/jmv.21524. J Med Virol. 2009. PMID: 19475605
The objective of this study was to evaluate the feasibility of using clinical parameters to demonstrate disease progression and differentiate between Omsk hemorrhagic fever virus (OHFV) and Russian spring-summer encephalitis virus (RSSEV) infection in the mou …
The objective of this study was to evaluate the feasibility of using clinical parameters to demonstrate disease progression and differentiat …
Complete genome sequencing and genetic characterization of Alkhumra hemorrhagic fever virus isolated from Najran, Saudi Arabia.
Madani TA, Azhar EI, Abuelzein el-TM, Kao M, Al-Bar HM, Farraj SA, Masri BE, Al-Kaiedi NA, Shakil S, Sohrab SS, SantaLucia J Jr, Ksiazek TG. Madani TA, et al. Intervirology. 2014;57(5):300-10. doi: 10.1159/000362334. Epub 2014 Jul 30. Intervirology. 2014. PMID: 25096447 Free article.
METHODS: The full-length genome of an AHFV strain isolated from patients in Najran (referred to as AHFV/997/NJ/09/SA) was PCR amplified and sequenced, and compared with the sequences of 18 other AHFV strains previously isolated from Jeddah and Makkah, dengue virus (DENV), Kyasanu …
METHODS: The full-length genome of an AHFV strain isolated from patients in Najran (referred to as AHFV/997/NJ/09/SA) was PCR amplified and …
Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane.
Vasilenko DA, Dueva EV, Kozlovskaya LI, Zefirov NA, Grishin YK, Butov GM, Palyulin VA, Kuznetsova TS, Karganova GG, Zefirova ON, Osolodkin DI, Averina EB. Vasilenko DA, et al. Bioorg Chem. 2019 Jun;87:629-637. doi: 10.1016/j.bioorg.2019.03.028. Epub 2019 Mar 16. Bioorg Chem. 2019. PMID: 30947098
In the present work a large series of novel polyfunctionalized isoxazole derivatives bearing substituents with various steric and electronic effects was obtained by our unique versatile synthetic procedure and their antiviral activity against tick-borne encephalitis, Omsk …
In the present work a large series of novel polyfunctionalized isoxazole derivatives bearing substituents with various steric and electronic …
Exploring of primate models of tick-borne flaviviruses infection for evaluation of vaccines and drugs efficacy.
Pripuzova NS, Gmyl LV, Romanova LIu, Tereshkina NV, Rogova YV, Terekhina LL, Kozlovskaya LI, Vorovitch MF, Grishina KG, Timofeev AV, Karganova GG. Pripuzova NS, et al. PLoS One. 2013 Apr 9;8(4):e61094. doi: 10.1371/journal.pone.0061094. Print 2013. PLoS One. 2013. PMID: 23585873 Free PMC article.
Tick-borne encephalitis virus (TBEV) is one of the most prevalent and medically important tick-borne arboviruses in Eurasia. There are overlapping foci of two flaviviruses: TBEV and Omsk hemorrhagic fever virus (OHFV) in Russia. Inactivated vaccines exist onl …
Tick-borne encephalitis virus (TBEV) is one of the most prevalent and medically important tick-borne arboviruses in Eurasia. There are overl …