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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 1
1951 1
1952 3
1953 2
1954 3
1955 4
1956 6
1957 5
1958 8
1959 3
1964 3
1965 12
1966 31
1967 34
1968 56
1969 50
1970 78
1971 74
1972 107
1973 99
1974 96
1975 169
1976 181
1977 175
1978 187
1979 165
1980 177
1981 188
1982 211
1983 233
1984 276
1985 267
1986 286
1987 298
1988 261
1989 342
1990 383
1991 409
1992 440
1993 510
1994 517
1995 548
1996 609
1997 614
1998 700
1999 700
2000 787
2001 872
2002 999
2003 1054
2004 1220
2005 1294
2006 1538
2007 1500
2008 1700
2009 1776
2010 1937
2011 2132
2012 2289
2013 2413
2014 2567
2015 2579
2016 2505
2017 2563
2018 2558
2019 2742
2020 2803
2021 2525
2022 2317
2023 2113
2024 696

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50,766 results

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Quoted phrase not found in phrase index: "Palmoplantar keratoderma, nonepidermolytic, focal or diffuse"
Page 1
What can we see with IVIM MRI?
Le Bihan D. Le Bihan D. Neuroimage. 2019 Feb 15;187:56-67. doi: 10.1016/j.neuroimage.2017.12.062. Epub 2017 Dec 22. Neuroimage. 2019. PMID: 29277647 Free article. Review.
The IVIM concept has been used to estimate perfusion in tissues as blood flow in randomly oriented capillaries mimics a pseudo-diffusion process. IVIM-based perfusion MRI, which does not require contrast agents, has gained momentum recently, especially in the field …
The IVIM concept has been used to estimate perfusion in tissues as blood flow in randomly oriented capillaries mimics a pseudo-dif …
Neuroprotection.
Lees KR. Lees KR. Br Med Bull. 2000;56(2):401-12. doi: 10.1258/0007142001903049. Br Med Bull. 2000. PMID: 11092089 Review.
Potential drug targets include elements of the excitotoxic glutamate cascade, calcium entry, intracellular protease activation, free radical damage, the inflammatory response and membrane repair. Clinical trials with many agents have so far been disappointing, but hindsigh …
Potential drug targets include elements of the excitotoxic glutamate cascade, calcium entry, intracellular protease activation, free radical …
Network bypasses sustain complexity.
Estrada E, Gómez-Gardeñes J, Lacasa L. Estrada E, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2305001120. doi: 10.1073/pnas.2305001120. Epub 2023 Jul 25. Proc Natl Acad Sci U S A. 2023. PMID: 37490534 Free PMC article.
Real-world networks are neither regular nor random, a fact elegantly explained by mechanisms such as the Watts-Strogatz or the Barabasi-Albert models, among others. Both mechanisms naturally create shortcuts and hubs, which while enhancing the network's connectivity, also …
Real-world networks are neither regular nor random, a fact elegantly explained by mechanisms such as the Watts-Strogatz or the Baraba …
Translational diffusion of unfolded and intrinsically disordered proteins.
Nesmelova IV, Melnikova DL, Ranjan V, Skirda VD. Nesmelova IV, et al. Prog Mol Biol Transl Sci. 2019;166:85-108. doi: 10.1016/bs.pmbts.2019.05.004. Epub 2019 Jun 8. Prog Mol Biol Transl Sci. 2019. PMID: 31521238 Review.
Translational (or self-diffusion) coefficient in dilute solution is inversely proportional to the size of a diffusing molecule, and hence self-diffusion coefficient measurements have been applied to determine the effective hydrodynamic radii for a range of na …
Translational (or self-diffusion) coefficient in dilute solution is inversely proportional to the size of a diffusing molecule …
Oral controlled release dosage forms: dissolution versus diffusion.
Bermejo M, Sanchez-Dengra B, Gonzalez-Alvarez M, Gonzalez-Alvarez I. Bermejo M, et al. Expert Opin Drug Deliv. 2020 Jun;17(6):791-803. doi: 10.1080/17425247.2020.1750593. Epub 2020 Apr 20. Expert Opin Drug Deliv. 2020. PMID: 32248713 Review.
They are particularly of interest in chronic diseases, for narrow therapeutic index drugs or for targeting a particular gastrointestinal tract (GI) segment. AREAS COVERED: Diffusion and dissolution limited controlled release systems are described in terms of release kineti …
They are particularly of interest in chronic diseases, for narrow therapeutic index drugs or for targeting a particular gastrointestinal tra …
Drugs in phase I and phase II clinical trials for systemic sclerosis.
Chung MP, Chung L. Chung MP, et al. Expert Opin Investig Drugs. 2020 Apr;29(4):349-362. doi: 10.1080/13543784.2020.1743973. Epub 2020 Mar 25. Expert Opin Investig Drugs. 2020. PMID: 32178544 Free PMC article. Review.
We performed a search on Pubmed and https://clinicaltrials.gov with keywords systemic sclerosis, Phase I clinical trial, and Phase II clinical trial to identify relevant studies from 2015 to 2019.Expert opinion: Therapeutic interventions in SSc should …
We performed a search on Pubmed and https://clinicaltrials.gov with keywords systemic sclerosis, Phase I clinical trial, and P …
Assessment of skin involvement in systemic sclerosis.
Kumánovics G, Péntek M, Bae S, Opris D, Khanna D, Furst DE, Czirják L. Kumánovics G, et al. Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v53-v66. doi: 10.1093/rheumatology/kex202. Rheumatology (Oxford). 2017. PMID: 28992173 Free PMC article. Review.
Skin involvement in SSc is an important marker of disease activity, severity and prognosis, making the assessment of skin a key issue in SSc clinical research. We reviewed the published data assessing skin involvement in clinical trials and summarized the major conc …
Skin involvement in SSc is an important marker of disease activity, severity and prognosis, making the assessment of skin a key issue in SSc …
Diffusion time dependency of extracellular diffusion.
Xu J, Xie J, Semmineh NB, Devan SP, Jiang X, Gore JC. Xu J, et al. Magn Reson Med. 2023 Jun;89(6):2432-2440. doi: 10.1002/mrm.29594. Epub 2023 Feb 5. Magn Reson Med. 2023. PMID: 36740894
PURPOSE: To quantify the variations of the power-law dependences on diffusion time t or gradient frequency f of extracellular water diffusion measured by diffusion MRI (dMRI). ...It is essential to determine the appropriate diffusion time range when mo …
PURPOSE: To quantify the variations of the power-law dependences on diffusion time t or gradient frequency f of extracellular water …
Small endogenous molecules as moiety to improve targeting of CNS drugs.
Sutera FM, De Caro V, Giannola LI. Sutera FM, et al. Expert Opin Drug Deliv. 2017 Jan;14(1):93-107. doi: 10.1080/17425247.2016.1208651. Epub 2016 Jul 15. Expert Opin Drug Deliv. 2017. PMID: 27367188 Review.
In particular, this overview focuses on aminoacidic, glycosyl, purinergic, ureic and acidic fragments derivatives, most of which can take advantage from BBB carrier-mediated transporters, where passive diffusion is not permitted. Expert opinion: In the authors' perspective …
In particular, this overview focuses on aminoacidic, glycosyl, purinergic, ureic and acidic fragments derivatives, most of which can take ad …
Hyaluronidase: from clinical applications to molecular and cellular mechanisms.
Buhren BA, Schrumpf H, Hoff NP, Bölke E, Hilton S, Gerber PA. Buhren BA, et al. Eur J Med Res. 2016 Feb 13;21:5. doi: 10.1186/s40001-016-0201-5. Eur J Med Res. 2016. PMID: 26873038 Free PMC article. Review.
The enzyme is considered a "spreading factor" as it decomplexes hyaluronic acid (also called hyaluronan, HA), an essential component of the extracellular matrix (ECM). When applied as an adjuvant, hyaluronidase enhances the diffusion capacity and bioavailability of injecte …
The enzyme is considered a "spreading factor" as it decomplexes hyaluronic acid (also called hyaluronan, HA), an essential component of the …
50,766 results
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