Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies.
Laurell GL, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen GM; Karolinska Schizophrenia Project Consortium; Ogden RT, Zanderigo F, Cervenka S, Hillmer AT, Schain M.
Laurell GL, et al.
J Nucl Med. 2021 Mar;62(3):412-417. doi: 10.2967/jnumed.120.243717. Epub 2020 Jul 17.
J Nucl Med. 2021.
PMID: 32680926
Free PMC article.
Since V(T) is the sum of the ligand-specific distribution volume (V(S)) and the nondisplaceable-binding distribution volume (V(ND)), differences in V(ND) across subjects and groups will have an impact on V(T)Methods: Here, we used a recently developed method for simultaneous esti …
Since V(T) is the sum of the ligand-specific distribution volume (V(S)) and the nondisplaceable-binding distribution volume (V(ND)), differe …