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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 2
1975 1
1976 1
1977 3
1980 1
1981 1
1985 2
1988 1
1996 1
1997 2
1998 1
2015 1
2019 1
2022 1
2024 0

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Page 1
Perlapine and dopamine metabolism: prediction of antipsychotic efficacy.
Wilk S, Stanley M. Wilk S, et al. Eur J Pharmacol. 1977 Jan 7;41(1):65-72. doi: 10.1016/0014-2999(77)90372-7. Eur J Pharmacol. 1977. PMID: 12986
All four drugs produced a dose-dependent increase in DOPAC in the two dopamine-rich structures. The potency of perlapine was similar to that of chlorpromazine. Dopamine, assayed in the striatum and tuberculum olfactorium by a new gas chromatographic procedure was not alter …
All four drugs produced a dose-dependent increase in DOPAC in the two dopamine-rich structures. The potency of perlapine was similar …
Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat.
Bürki HR, Ruch W, Asper H. Bürki HR, et al. Psychopharmacologia. 1975;41(1):27-33. doi: 10.1007/BF00421302. Psychopharmacologia. 1975. PMID: 235767
The effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat have been investigated. Haloperidol, perlapine and thioridazine induce catalepsy and enhance the turnover of DA in the striatum as indi …
The effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat ha …
Perlapine: relationship between stimulation of prolactin secretion and antipsychotic activity.
Meltzer HY, Fessler RG, Fang VS. Meltzer HY, et al. Psychopharmacology (Berl). 1977 Oct 20;54(2):183-6. doi: 10.1007/BF00426777. Psychopharmacology (Berl). 1977. PMID: 412213
Perlapine is a dibenzohetereopine compound chemically related to clothiapine, loxapine, and clozapine. ...The order of potency is loxapine, perlapine, clothiapine, and clozapine. These results suggest that either perlapine should be reexamined for antipsychot …
Perlapine is a dibenzohetereopine compound chemically related to clothiapine, loxapine, and clozapine. ...The order of potency is lox …
Chemogenetic activation of VGLUT3-expressing neurons decreases movement.
Kljakic O, Hogan-Cann AE, Yang H, Dover B, Al-Onaizi M, Prado MAM, Prado VF. Kljakic O, et al. Eur J Pharmacol. 2022 Nov 15;935:175298. doi: 10.1016/j.ejphar.2022.175298. Epub 2022 Oct 2. Eur J Pharmacol. 2022. PMID: 36198338
We observed that clozapine-N-oxide (CNO), clozapine, compound 21 and perlapine show small differences in the speed at which they prompt behavioural responses but the four of them are selective DREADD ligands....
We observed that clozapine-N-oxide (CNO), clozapine, compound 21 and perlapine show small differences in the speed at which they prom …
The effects of perlapine on sleep.
Allen SR, Oswald I. Allen SR, et al. Psychopharmacologia. 1973 Aug 22;32(1):1-9. doi: 10.1007/BF00421703. Psychopharmacologia. 1973. PMID: 4359662 No abstract available.
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
Seeman P, Corbett R, Van Tol HH. Seeman P, et al. Neuropsychopharmacology. 1997 Feb;16(2):93-110; discussion 111-35. doi: 10.1016/S0893-133X(96)00187-X. Neuropsychopharmacology. 1997. PMID: 9015795 Review.
However, because clozapine competes with endogenous dopamine, the in vivo concentration of clozapine (to occupy dopamine D4 receptors) can be derived to be about 13 nM, agreeing with the value of 12 to 20 nM in the plasma water or spinal fluid observed in treated patients. The at …
However, because clozapine competes with endogenous dopamine, the in vivo concentration of clozapine (to occupy dopamine D4 receptors) can b …
Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.
Seeman P, Tallerico T. Seeman P, et al. Mol Psychiatry. 1998 Mar;3(2):123-34. doi: 10.1038/sj.mp.4000336. Mol Psychiatry. 1998. PMID: 9577836 Review.
As determined by the new dissociation constants, antipsychotic drugs which elicit Parkinsonism (trifluperazine, chlorpromazine, raclopride, haloperidol, fluphenazine, risperidone) bind more tightly than dopamine to D2, while those antipsychotic drugs which elicit little or no Par …
As determined by the new dissociation constants, antipsychotic drugs which elicit Parkinsonism (trifluperazine, chlorpromazine, raclopride, …
Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.
Weston M, Kaserer T, Wu A, Mouravlev A, Carpenter JC, Snowball A, Knauss S, von Schimmelmann M, During MJ, Lignani G, Schorge S, Young D, Kullmann DM, Lieb A. Weston M, et al. Sci Adv. 2019 Apr 17;5(4):eaaw1567. doi: 10.1126/sciadv.aaw1567. eCollection 2019 Apr. Sci Adv. 2019. PMID: 31001591 Free PMC article.
A major obstacle, however, is that the widely used agonist clozapine N-oxide undergoes conversion to clozapine, which penetrates the blood-brain barrier but has an unfavorable side effect profile. Perlapine has been reported to activate DREADDs at nanomolar concentrations …
A major obstacle, however, is that the widely used agonist clozapine N-oxide undergoes conversion to clozapine, which penetrates the blood-b …
Dopamine and serotonin receptors: amino acid sequences, and clinical role in neuroleptic parkinsonism.
Seeman P, Corbett R, Nam D, Van Tol HH. Seeman P, et al. Jpn J Pharmacol. 1996 Jul;71(3):187-204. doi: 10.1254/jjp.71.187. Jpn J Pharmacol. 1996. PMID: 8854201 Free article. Review.
This analysis supports the concept and practical value of the intrinsic K values. Some atypical neuroleptics (remoxipride, clozapine, perlapine, seroquel and melperone) have high intrinsic K values (ranging from 30 to 88 nM) at the D2-receptor, making them displaceable by …
This analysis supports the concept and practical value of the intrinsic K values. Some atypical neuroleptics (remoxipride, clozapine, per …
19 results